Side effects, treatments, and more

Side effects, treatments, and more

Prolactin is a hormone that the pituitary gland generates. Superior concentrations of prolactin may perhaps arise due to medicines, health problems, or prolactinomas, which are benign tumors of the pituitary gland.

Prolactin plays an critical function in the balanced functioning of the body. Insufficient or extreme stages of prolactin could bring about overall health challenges.

Noncancerous tumors of the pituitary gland, known as prolactinomas, can cause substantial levels of prolactin and other health problems.

In this write-up, we seem at the role of prolactin in the system, signs and symptoms of prolactinomas or significant prolactin stages, and treatment options for inadequate or abnormal concentrations of this hormone.

Prolactin is a hormone that assists breast advancement, specifically in females. It will help the human body manage an over-all secure ailment and also makes it possible for nursing people today to lactate.

The pituitary gland generates prolactin. This gland sits at the base of the brain and assists regulate hormones in the body.

Insufficient or excessive prolactin ranges can result in wellness challenges.

A prolactinoma is a noncancerous tumor in the pituitary gland. Prolactinomas produce prolactin, which can direct to high degrees of this hormone in the entire body.

There is no recognized lead to for prolactinomas, but genetics may enjoy a component in some situations. For case in point, several endocrine neoplasia type 1 is a genetic dysfunction that might boost the risk of producing prolactinomas.

Prolactinomas are more common in females than males and are a lot more commonplace in women aged 25–34 decades.

It is usual for prolactin ranges to increase during being pregnant and upper body or breastfeeding.

Other variables can also result in a slight, short-term spike in prolactin stages, which include:

  • physical tension on the human body
  • work out
  • sexual intercourse
  • taking in a food
  • nipple stimulation
  • upper body damage
  • epileptic seizures

Apart from prolactinomas, higher prolactin amounts may well also consequence from health situations or using particular medicines.

Medications

Dopamine, a chemical in the mind, can help control prolactin production. Medications that have an impact on dopamine concentrations may possibly result in improved prolactin concentrations.

Drugs that may cause higher prolactin concentrations involve:

Health and fitness ailments

Certain health and fitness ailments may well result in a increase in prolactin concentrations, these kinds of as:

Prolactinomas or high prolactin stages in women could trigger:

Large prolactin concentrations in males may trigger erectile dysfunction or low testosterone concentrations, which may perhaps bring about a reduction of desire in sex.

Males may possibly also working experience headaches and milk-like discharge from the nipple.

Significant prolactin degrees may perhaps have inbound links to certain temper disorders. A 2021 examine identified that individuals with main depressive condition (MDD) had increased prolactin than those people without having the situation.

Prolactin aids control stress and also has associations with anxiousness, body weight gain, and hostility. Better degrees of the hormone may well also increase the chance of developing psychosis.

MDD impacts how the nervous system and endocrine procedure interact. The over 2021 research also implies that MDD may well also disrupt the manufacturing of prolactin.

To diagnose high prolactin levels, doctors will acquire a blood examination to evaluate the sum of prolactin in the blood.

If individuals have superior prolactin degrees, medical professionals will then carry out imaging assessments to check for a prolactinoma.

Physicians may use an MRI scan to generate a in depth graphic of the pituitary gland and bordering region. If an MRI is unsuitable, a person may possibly go through a CT scan.

Imaging tests allow health professionals to see if a prolactinoma is existing and establish its location and dimension.

Therapy can assist to return prolactin levels to regular stages and treat any prolactinomas that might be present.

Treatment

The most widespread therapy for prolactinomas is medication, which can shrink the prolactinoma and regulate prolactin levels.

Dopamine agonists are medicines that act equally to dopamine in the brain. They are an successful therapy in shrinking prolactinomas and controlling prolactin levels.

Doctors could prescribe bromocriptine, which people today may possibly require to just take 2–3 instances every day. They might also require cabergoline, which may well be more productive and have much less facet consequences than bromocriptine. Persons may possibly will need to get this 1–2 instances a week.

A man or woman may have to have to consider treatment for 2 years or much more till the prolactinoma is no more time visible. If prolactin degrees increase, they may perhaps have to keep on medication to cut down them again.

If remedies are resulting in higher prolactin stages, halting taking the drug will normally result in prolactin degrees to return to regular levels within 3–4 times.

Nevertheless, it is vital to talk with a physician in advance of halting any prescription medicine.

Operation

If medication is ineffective in managing a prolactinoma, folks may perhaps demand operation to clear away the tumor. A physician will execute the surgical procedures underneath a standard anesthetic.

Sorts of surgical treatment to take away a prolactinoma contain:

  • Transsphenoidal medical procedures: This is the most widespread variety of prolactinoma surgery. A surgeon will make a minimize powering the nasal cavity or less than the upper lip to have out the technique.
  • Transcranial operation: People today might need this form of surgical treatment if the prolactinoma is significant or has distribute outside the house the pituitary gland. A surgeon will make an opening in the cranium to get rid of the tumor.

The pituitary gland produces the hormone prolactin, which is essential for the suitable working of the overall body.

Nonetheless, significant prolactin concentrations can result in health troubles, this kind of as irregular durations and infertility in females and very low testosterone concentrations and erectile dysfunction in males.

Prolactinoma, a benign tumor of the pituitary gland, can also result in superior prolactin ranges. Men and women might will need remedies or operation to shrink the tumor and lower prolactin concentrations.

If medicine or an underlying health condition is triggering superior prolactin stages, halting the medication or managing the underlying ailment may perhaps help return prolactin stages to expected concentrations.

If people today have any signs and symptoms of significant prolactin amounts or prolactinoma, they will will need to discuss with a medical doctor for a analysis.

Monkeypox is a global health emergency: What to know

Monkeypox is a global health emergency: What to know

gloved hand extracting dose of monkeypox vaccineShare on Pinterest
The WHO has declared monkeypox a global health emergency. How can a person prevent infection? Image credit: Al Diaz/Miami Herald/Tribune News Service via Getty Images.
  • Earlier this month, the World Health Organization (WHO) declared the recent monkeypox outbreak a global health emergency.
  • There are more than 16,000 reported cases of monkeypox within 75 countries and territories.
  • Monkeypox has a current fatality rate of between 3-6{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}.
  • A recent study found 95{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of monkeypox cases between April and June 2022 occurred during sex between men.
  • Two vaccines are currently available to help protect against monkeypox.

On July 23, 2022, WHO’s Director-General Tedros Adhanom Ghebreyesus declared the recent monkeypox outbreak a “public health emergency of international concern (PHEIC).”

According to Dr. Tedros’ official press statement, this decision stems from the current monkeypox outbreak growing to more than 16,000 reported cases within 75 countries and territories, along with five deaths.

“I welcome the decision of the WHO Director to declare the current global monkeypox outbreak a PHEIC,” comments Dr. Boghuma K. Titanji, assistant professor of medicine at Emory University. “For several weeks now the criteria for making monkeypox a PHEIC had been met.”

“I hope that this will raise the international priority level on monkeypox and galvanize a more coordinated global response which has sadly been lacking so far,” she continues.

“It is also an opportunity to get things right on global health equity and access to resources such as testing, vaccination, antiviral medications, etc. which are areas in which historically we have seen many failures, resulting in countries with limited resources being left behind.”

– Dr. Boghuma K. Titanji

Monkeypox is a zoonotic virus, meaning it transfers from animals to humans. Some animals that can carry monkeypox include various species of monkeys, giant-pouched rats, African dormice, and certain types of squirrels.

The disease belongs to the Orthopoxvirus genus of viruses, which also includes smallpox. Because of that, its symptoms are generally similar to, but not as severe as those of smallpox.

Medical clinicians found the first cases of monkeypox in 1958 during two outbreaks in monkeys being kept for research.

Researchers recorded the first human case of the disease in 1970 in the Democratic Republic of the Congo. Since then, 11 African countries have reported cases of monkeypox.

The first monkeypox outbreak outside of Africa happened in the United States in 2003. Scientists tied this incident to prairie dogs infected with monkeypox.

As previously mentioned, monkeypox is a virus that transfers from infected animals to humans. Transfer of the virus from an animal to a human occurs through:

  • being bitten or scratched by an infected animal
  • eating meat or using products from an animal with monkeypox
  • coming into contact with an infected animal’s body fluids.

Once a human becomes infected with monkeypox, they can transfer the virus to another human through:

  • respiratory droplets during prolonged face-to-face contact
  • intimate physical contact, including kissing and sexual intercourse
  • directly touching the infectious rash or body fluids of an infected person
  • touching clothing, bedding, and other materials that have been in contact with an infected person’s rash or body fluids.

Because monkeypox is spread between humans through close contact, the Centers for Disease Control (CDC) offers guidelines for people who are sexually active to protect themselves and their partners from contracting the virus.

A recently released study in the New England Journal of Medicine found that, between April and June 2022, 98{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of the persons with a monkeypox infection were gay or bisexual men, and 95{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of monkeypox cases occurred through sexual transmission.

Is monkeypox, then, a sexually transmitted disease (STD)?

According to Prof. Piero Olliaro, director of clinical research at the Epidemic Diseases Research Group Oxford (ERGO) and International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC), not so.

He emphasized it is important to remember that monkeypox is transmitted on the occasion of close contact via a variety of means. That includes sexual intercourse, but that is not the only means of transmission.

While the virus does not only circulate through intercourse, the fact that it can transmit through respiratory droplets might mean that it may more easily transmit between members of close-knit communities, such as LGBTQIA+ communities.

“The fact that the current outbreak in non-endemic countries is — so far — essentially involving men who have sex with men means the involvement and buy-in of the LGBTQ+ community is essential,” Prof. Olliaro also told Medical News Today.

“This has proven to work in other similar circumstances to help identify what would work, and make it happen to break the chains of transmission,” he added.

If a person becomes infected with monkeypox, the incubation period before they begin to show symptoms lasts anywhere from 5 to 21 days.

Most people experience two sets of monkeypox symptoms. The first symptoms occur for about 5 days and include:

A few days after having a fever, a rash normally appears on the person infected with monkeypox. The rash looks similar to pimples or blisters and can appear on many parts of the body, including:

  • face
  • chest
  • palms of the hands
  • soles of the feet
  • inside the mouth
  • genitals and/ or anus.

Symptoms normally last between two to four weeks. Monkeypox currently has a fatality rate of 3{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} to 6{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}.

Disease treatment normally includes medications to treat certain symptoms.

Tecovirimat (TPOXX) is an antiviral drug developed by SIGA Technologies for the treatment of smallpox and related diseases. According to Dr. Dennis Hruby, chief scientific officer at SIGA Technologies, TPOXX is the only approved antiviral for the treatment of monkeypox.

The public health agencies that have so far approved TPOXX for the treatment of monkeypox infection are the European Medicines Agency (EMA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) in the United Kingdom.

In the United States, the Food and Drug Administration (FDA) approved Tecovirimat for the treatment of smallpox, but not currently monkeypox.

For that reason, the CDC holds a non-research expanded access Investigational New Drug (EA-IND) protocol allowing clinicians to use tecovirimat to treat all orthopoxvirus infections, including monkeypox, in both children and adults.

“The U.S. has 1.7 million courses of TPOXX in the strategic national stockpile,” Dr. Hruby told MNT. “It is distributed by the CDC under an EA-IND for the treatment of monkeypox. SIGA has donated small quantities of tecovirimat to the U.K. for use in the most severe cases.”

Two vaccines are currently available for monkeypox.

The FDA approved the JYNNEOS vaccine — also known as Imvanex — for preventing smallpox and monkeypox. The U.S. Health and Human Services announced in early July the ordering of 2.5 million additional doses of the JYNNEOS vaccine.

The EMA recently recommended the use of Imvanex to help protect adults from monkeypox.

The JYNNEOS vaccine includes two shots, with people considered fully vaccinated about 2 weeks after the second shot.

The second vaccine, ACAM2000, is approved to prevent smallpox in the U.S. and has an expanded access IND for monkeypox.

The ACAM2000 vaccine includes only one shot and considers a person vaccinated about 4 weeks after. Additionally, clinicians recommend certain populations do receive the ACAM2000 vaccine, including:

While vaccination is important, Prof. Olliaro stressed it may not be the complete solution.

“Vaccination alone may not work unless supported by other measures — including also capacity to diagnose and treat early,” he emphasized.

Medical professionals suggest people take the following steps to help prevent the spread of monkeypox:

  • avoid intimate and skin-to-skin contact with a person who has a rash similar to that of monkeypox
  • try not to touch bedding, clothing, or other materials that may have touched a person with monkeypox
  • wash hands frequently with soap and water
  • in certain African regions, keep away from known animal carriers of monkeypox, and do not touch sick or dead animals.

The sustainability revolution in fashion supply chains

The sustainability revolution in fashion supply chains

In this episode of the McKinsey Global Institute’s Forward Thinking podcast, co-host Janet Bush talks to Edwin Keh, the CEO of the Hong Kong Research Institute of Textiles and Apparel. It was set up in 2006, with the aim of becoming a center of excellence in research and development in the fashion and textiles industry. The institute has won awards for garment recycling and for its work on a yarn that captures carbon dioxide from the air. Keh is also on the faculty at the Wharton School, University of Pennsylvania, and the Hong Kong University of Science and Technology. He has long experience in the retail business, working for Walmart and Donna Karan, among others.

An edited transcript of this episode follows. Subscribe to the series on Apple Podcasts, Google Podcasts, Spotify, Stitcher, or wherever you get your podcasts.

Audio


Forward Thinking on the sustainability revolution in textiles and the fashion industry with Edwin Keh

Podcast transcript

Janet Bush (co-host): Michael, supply chains are very much in the news at the moment. During the pandemic and now in the wake of Russia’s invasion of Ukraine, we have learned quite how vulnerable they can be. But they can also be very long. If you were to rank global supply chains for length, where do you think the fashion and textiles one would sit?

Michael Chui (co-host): My hunch would be it must be one of the longest. The fabric starts its life in a cotton field or even nowadays maybe in a lab. There is dying and processing, and then manufacturing of garments. Cost is such a key consideration in fashion that it tends to take place in low-wage emerging economies. But design may take place in any number of locations. And then everything has
to get to consumers, and they are all over the world. And of course many of these stages aren’t very positive for the environment.

Janet Bush: Yes indeed. Our guest today has been working on supply chains in the retail industry for many years and now at his institute in Hong Kong he has been thinking hard about how to shorten the textiles and fashion supply chain and crucially how to make it more sustainable. They are inventing new materials and reinventing processes.

Michael Chui: Wow. I am very much looking forward to hearing the conversation. Over to you, Janet.

Janet Bush: Welcome, Edwin. I’m so pleased that you could join us today. I just wanted to ask by starting a bit about you, your background. Where did you grow up? What did you study? What were your interests?

Edwin Keh: Thanks for having me. I grew up in Hong Kong. I don’t sound like I’m from Hong Kong because my wife is American, and this accent is for good in-law management. I studied urban design. My undergraduate degree is [in] urban design. And I thought I was going to be a sociologist.

In fact, I was on my way to get my PhD in sociology when I took what I thought was a summer job working for the United Nations High Commissioner for Refugees, the [UN]HCR, in one of the refugee camps. And I had one of the most frustrating work experiences, because I was watching people die unnecessarily in refugee camps. And I couldn’t
figure out how to get resources to them. That actually prompted a shift in my thinking.

I went to business school. And that got me down the road to looking at enterprises and supply chains. And I stayed in supply chains for about 30 years.

Janet Bush: So do you regard yourself as primarily a businessman?

Edwin Keh: Accidentally, I think. I was always curious about organizational behavior, organizational structures, and how groups of people organize themselves to get things done in a more efficient manner. And business was a much more efficient way of looking at that rather than not-for-profits, where they don’t have as clear and/or sharp metrics.

But I also took a left turn, if you will. As you mentioned in your introduction, I got to a point in my career in which I stepped off the corporate ladder and decided I wanted to spend more time thinking,
doing more research, and do something different. And so I stepped off to run a research institute and became an academic and a researcher, to find out more about how I screwed up in the last 30 years of my career.

Janet Bush: You say that, but did you enjoy being in business? You were in retail, largely. How did you get into retail? And what was fun about it?

Edwin Keh: I got into retail because I thought it was a fascinating way to learn more about the world. And particularly in the textile, apparel, and fashion industry because for whatever reason, we built this very, very long, globalized supply chain. It is probably one of the most globalized supply chains of any industry in the world.

I’m very curious about how these things work. It fascinated me. And it’s not a very static area. There’s so many changes. There’s technology, science, and all the new trends. And all the social movements that came along during my career. So I found it endlessly exciting.

But I did feel, at some point, that I wanted to understand the causality behind the phenomenon, which is why I stepped off. One of the reasons why I stepped off.

Janet Bush: In a recent interview, you were described as the godfather of Hong Kong’s fashion sustainability industry. And it’s clear that your institute is doing lots of extremely exciting work. But what led you to focus on sustainability, having been in retail and having been so close to the fashion industry?

Edwin Keh: I was trying to figure out what was going on. We did a large survey with stakeholders. And three big domains, three big answers I kept getting over and over again as I talked with people were: they really wanted to solve for sustainability, because that’s something that everybody in every part of the supply chain was asking for, seeking solutions for.

And Industry 4.0. what do we do? We’re going from a labor-intensive to a more technology-intensive industry. How do we respond to that? And then, are there ways in which we can take the materials, the
learnings, the supply chain, and the processes in this industry and use it in other, adjacent industries?

Hospitality and high-performance sports. Elderly care. All those things became interesting domains for us. So those three domains have driven the work of the research center the last ten years. And they
sort of overlap into each other frequently.

Sustainability, for sure, has been something that has caught the imagination and the attention of a lot of stakeholders with our work. I think that’s what we’ve become known for.

Janet Bush: Before we get into the nitty-gritty
of what your institute is doing—the revolution that’s happening in fashion and sustainable materials—how big is the carbon footprint of the fashion industry?

I’ve read very arresting figures from the Ellen MacArthur Foundation. Every year, the foundation says, the fashion industry uses enough water to meet the consumption needs of five million people.
The fashion industry is responsible for 10 percent of annual global carbon emissions. And that’s more than all international flights and maritime shipping combined. I would love to get your take on those
figures, and give me some of your own.

Edwin Keh: I think those are all educated guesses,
would be how I look at those. I think they probably are as good as we can approximate today.

The fashion industry is certainly quite water-intensive. The dyeing, the processing, the wet processing that we do for our materials consume a lot of water, pollute a lot of water, and it is probably not the most efficient use of our valuable resources
that we have.

There are some numbers that would indicate that the industry is about five gigatons [of greenhouse gas emissions annually]. Some are higher. That depends on how far back you go into the supply chains—tier two, tier three, types of activities that drive some of this consumption.

Certainly there are other industries that are much bigger contributors to the problem. This is a significant and a high-profile contributor to the challenges we face. Almost all fashion purchases
are discretionary purchases.

None of us will freeze to death this winter if we don’t buy another jacket or something like that. It is something that is much more manageable and controllable. There are other industries that produce
a lot more emissions, but those may be much harder for us to look for alternatives to.

Janet Bush: To a certain extent, you’re pushing on an open door because of the discretionary nature of fashion. And that will depend on how we all collectively, as consumers, change. And I’ll go back to that point. But if you break down that carbon footprint, it seems to be a combination of dirty production, as you mentioned, and waste. So on the dirty production, how is the institute thinking about that aspect of the footprint?

Edwin Keh: For sure, if you look at the manufacturing part of the supply chain, that is where the opportunity is. That is where what type of materials we choose, how we process the
materials, how we manufacture the materials, how we transport the products—that’s where the biggest chunk of any fashion brand supply chain carbon footprint, that’s where that sits.

I mean, we can all change all the light bulbs in the store to LEDs, and it won’t move the needle. On the other hand, if we change something further upstream from there, that’s the opportunity. But I
think, to your point, it’s not only the carbon footprint, it’s also a lot of the other unhealthy things that we produce. The chemical waste. The solid waste. The dirty water, and things that we emit into the air. All those are opportunities for us to think about how we can improve on that.

One way to think about this challenge, or this opportunity, is if we think of our telephones. The telephone we’re using today and the telephone we were using ten years ago is a completely different
piece of instrument. It provides so much more functionality. It connects us. It protects us. It informs us. It is a tool that has changed with the times and with our needs.

If we bought a T-shirt ten years ago and we buy a T-shirt tomorrow, it’s essentially the same thing. This is the heaviest, dumbest system that we carry around with us. And it is passive. We have to take care of these things, our clothes. The other tools that we use take care of us. I think the opportunity is that we haven’t moved and changed. Nor have we progressed with the changing environment and lifestyle requirements.

Janet Bush: So that’s a huge scope to make a big difference.

Edwin Keh: Yes, yes. I think there are. We just haven’t—for all of the modernity that we think of this industry, it’s quite conservative. I remember talking to a brand recently, a luxury brand, and basically they said, “We haven’t changed suppliers for three generations.”

This “we’ve been doing this forever,” they’re very proud of that. And I was thinking, but why wouldn’t you? Why wouldn’t you embrace stuff? There are things that—we certainly have been slow. The opportunities are there.

Janet Bush: Why do you think that the fashion business, in the broader sense, is so conservative?

Edwin Keh: A couple things. Fundamentally, the relationship between the user of fashion products and the fashion brands and designers, if you will, has changed. And the industry is sort of trying to recapture some of its glories of its past.

Once upon a time, say, up to the 1990s, designers dictated to consumers what is beautiful, what the trends and the fashion magazines tell us, what the looks should be. That was a top down-event. Today
it’s a bottom-up event.

It’s a very social, very peer-to-peer type of activity. And yet we still have these illusions that we still have this old industry that we want to somehow preserve.

Maybe it’s the mating calls of dinosaurs or what-have-you. But I think secondly, too, there are some things that work. And we just haven’t figured out how to change with the times, because it has worked good enough. Or it’s profitable enough so that we don’t want to make the big changes. We’re all busy, right? This changing tires on a moving vehicle is hard.

Janet Bush: Just exploring a little bit more the dirty production and the fact that this is a very thirsty industry, I believe that you are trialing, in India, a material that came out of your recycling efforts that is very, very water absorbent. And that it is possible that it might be possible to grow cotton with much less water. Or any water. Could you tell us about that? Because it sounds fascinating.

Edwin Keh: We’re actually on our third large-scale experiment, growing experiment, with this. We’ve been interested in cotton, and cellulose in general, because we want to look for some future solution that is cellulose-based. And perhaps some protein-based solutions, so that it can take the place [of] a lot of the petroleum-based materials that we use today.

In the cellulose experiments, we were messing around with recycling of cellulose. We’d been looking at, What are some high-value outputs that we can create with these recycled materials? And one of the answers is, we functionalized cellulose, recycled cellulose, into a super-absorbent polymer. This is a polymer that absorbs about 30 times its weight in water, and then it releases it. And then it does it again repeatedly.

We looked at this as an opportunity to improve the root health of cotton plants while they’re growing. And we’ve been successful essentially now, to grow cotton without irrigation. Just using this material. It pulls moisture in from the ambient environment and stores it and releases it in the appropriate time, right at the root. And so cotton grows faster. The quality of cotton fiber is better, because the overall plant is healthier.

And the yield improves per acre. Double-digit yield improvement on a per-acre basis. So we’re quite excited about this. Right now we are scaling it up in India to make sure that we get the proportions right.

But we’re also developing the second generation of this material, in which we’re adding nutrients into the polymer so that it can also take the place of fertilizer and things like that. Concurrently, we’re also working on a third generation of this material to do all of that but in a much more efficient manufacturing process.

We’re juggling a couple of balls there. But the whole idea is—places like India, you already see the effects of climate change and extreme climate. A lot of the places that we’re working with have had really, really hot summers. There are some that have very little water. Other places have flooding.

I think going forward, the places where we can grow cotton traditionally may get narrower and narrower. What if we have these types of materials that can help us grow cotton? Grow it faster, because we were working directly with farmers in this project.

Can we get another season out of them? So that they not only grow more cotton and are healthier yields, but can we do it more frequently?

Can we use this material to improve the soil health so that we put some of the nutrients back into the soil? And can we grow cotton in marginal land? Places that in the past just weren’t right to grow cotton? These are all things that we’re trying to work on as quickly as possible. The challenge with this project is that every time we have an experimental question, it takes six months to answer it, because that’s how long it takes to grow cotton.

Janet Bush: The other exciting project is this apron, or this fabric, this T-shirt that “eats” carbon from the air.

Edwin Keh: It’s actually half a project. We’re halfway through it. But Fotografiska, the Swedish museum, heard about it, coincidentally, because we do some work with the H&M Foundation. They got very excited about it. And it’s now a part of their uniform in the restaurant. A very nice restaurant in Stockholm.

We have been functionalizing cotton materials to absorb carbon dioxide. Because we’ve been interested in biodiversity and carbon neutrality as part of our recent research themes. So we developed this functionalized cotton material that absorbs it, and in T-shirt form, it’s about one-third of a tree. A day’s worth of carbon dioxide that is absorbed just in the ambient as you use this shirt.

We were very excited about it. That’s the first part of the experiment. The second part of the experiment that we’re working on right now is a chemical release mechanism. Can we keep the carbon dioxide that we sequester in a solid form? We’re working on some calcium carbonate–based types of solutions.

We’re basically trying to develop a detergent so that as consumers wash this material, it pulls all the carbon dioxide out and keeps it in a solid form. What happened there was that we told the museum, “Yes, we’ve figured out the absorption part. We’re now figuring out the sequestering part.”

They talked to us a little bit more about it. And we said, “Well, one of the mechanisms that we found success in doing the release part is that if you just heat up the T-shirt, then the CO2 gets
released again.”

They got very excited about it. Because they said, “Well, what if we release the CO2 in our greenhouse?” And I say, “Oh, that’s cool.” Because then, there, the plants can use it as part of the photosynthesis process and actually then you have this cool cycle.

They just happened to have, in their basement, a sealed greenhouse where they grow their salads and their herbs. So they have a very elegant little loop. It’s a uniform during the day, and then at night,
they take all the uniforms and they put it in the greenhouse. It gets heated up. The carbon dioxide gets released. The plants use it. And they take the uniforms out in the morning and the cycle goes over again.

We’re very happy about that idea. And we’re looking at solutions like that for sequestering. Can we take CO2 that we produce during the production process and use it as food for plants? So that we can use it in the growing of cotton, let’s say. And so that we sequester the CO2 that we produce? And that stays stable in a cotton form? It’s the beginning of exploration. We’re very excited. We’re looking for different products out of that.

Just so we contextualize this, we’re a small, applied research center. We start about 20 to 30 new projects every year. We have about 50 to 60 ongoing projects. We’ve completed about 200 projects. We have a lot of research going on. And we recently decided that we’re going to put all of our sustainability research in one lab. And we found that we have an inventory of 60 to 70 sustainability-, circularity-, recycling-related projects that we’re building out.

Janet Bush: Of all these projects that you have on the stocks or are planning—without giving away state secrets, which are the ones that excite you the most?

Edwin Keh: One of the things that we have observed is that the best opportunities for making breakthroughs, and for disruptions, are at the extremes of the supply chain. If you get as close as possible to the raw material, you can influence where we start. What do we work on?

And then if you get very close to consumer or post-consumer, at the point of sale, there’s opportunities to work on new business models. We’ve talked about the material side, we have ongoing research. We have a cool hydroponic project.

We were building something called “the world’s shortest supply chain,” where we go from raw material to garment all in—I’m shooting for, like, one 40-foot container, but my team tells me it has to be
two 40-foot containers. Completely discharge-free. Self-sustaining. Enclosed, location-free type of solution where you can grow anywhere and make anywhere. We’re excited about that extreme.

We’re also looking at different types of cellulose source. And the places that we are most excited about are looking at one—agricultural waste. Which there’s a lot of effort around the world on. Also saltwater-based solutions. Anything that we can grow in the oceans, so that we don’t have to compete with food for resources on the land, we think will be a good idea.

Lots of work there. And then on the other extreme, the point-of-sale and the consumer side, we’re looking at new business models. Highly intelligent business models. And new value. Can we sell services instead of products? How do we monetize ideas? How do we engage customers in different ways? And then the extended life of materials and products. How do we build in second use, third use into materials and products that we create?

Those two extremes, and then post-consumer recycling and all that. And building consumption-based economy solutions. Because things that we want to recycle, they are in the wrong parts of the world. They’re in the consuming economies where there are no capabilities to do any type of processing.

The factories are in the manufacturing economies. We have all this material there. Are there ways that we can provide highly intelligent, highly effective, highly automated solutions so that these can be
processed into other, high-value materials so that they can be used again and again? Cool things like that are ongoing.

Janet Bush: When we did our research at MGI on the Bio Revolution, we talked explicitly about innovation being the start of the journey. Then it’s commercialization, then it’s adoption. So it’s interesting that you’re talking about business models. Because that clearly has to be a huge part of your thinking. And obviously is.

How far are we along that journey with some of the innovations that you’ve been talking about? How far have we got to go to get to the commercialization and then the adoption, to the scale that will make a real difference?

Edwin Keh: The nightmare scenario is too little, too late, right? That we have these things, but we don’t get there till 2040 or something like that, by which time we’ve had some irreparable damage to our environment.

One of the things that we’re excited about is a disruption to the innovation model itself. How can we get solutions to the marketplace faster? A couple of principles. A long answer to your short question
is, one, we think that most real-world challenges are multidiscipline.

It’s a science problem. It’s a logistics problem. It’s a business-case problem. And you have to solve all of them for it to have a marketplace. What we’re doing is that instead of building scientific domain expertise, we intentionally put groups of people, groups of researchers from very different domains, together to collaborate on projects together.

We intentionally, in most of our projects, have different stakeholders up and down the supply chain, working together on these solutions so that we take into consideration the manufacturing challenges, the pricing challenges, the end-of-use or distribution challenges in the solution.

Working in quite a multidiscipline approach and trying to solve everything, one of our mantras there is that closure is overrated. And things will be a little bit messy. Just live with it.

The third principle we have there is what we call the software innovation model, which is that we are aiming for 1.0. We want to release 1.0 as quickly as possible. So we have a sense of impatience and a sense of urgency. And we don’t try to have perfection before we roll most of our solutions out. It’s the 1.0. We know that it’s got some bugs. We know we’ll have some patches along the way.

But we want to throw these solutions out in the marketplace as quickly as possible, and we’ll make the fixes and improvements as we scale up. It’s messy. It’s a little bit—you have to be confident that it’s solving the right things. And you have the confidence that if we have these exciting challenges and they are meaningful and useful, that the right people, the right help will come along. People will help us with the right solutions.

It is the conviction that we will get there. Because it’s the right thing to do. Failure is OK. But we expect to be successful. It’s a little bit of a tightrope walk. But you are optimistically impatient, I guess. Or something along that line.

It’s quite a roller-coaster ride for some of our team members. Especially our younger team members. If they’ve got their PhD, they tend to be quite more disciplined. And we say, “Well, throw that out the window. Let’s take some risks.”

Janet Bush: Going back to the consumer, is there a danger that consumers like me will stand in the way because they won’t adopt? Obviously you get to the point where everything is sustainable. Anything that they’re being offered on their online retailer is sustainable.

At the moment, there’s a smattering of dresses and T-shirts that say, “ecologically this” or “sustainable that.” I don’t know whether they are. And I tend to try and choose them if I like them. But it has to be a lot more than that. The scale to reach a tipping point has to be much bigger. How do you see the consumer reacting to all of this?

Edwin Keh: There’s a couple of perspectives that we have on this. You’re right, there is enough consumer education in which there’s aspiration for consumers to say, “I want to be greener in my consumption, in the choices I make.”

But also, on the other hand, there are some consumer inconsistencies. I’m still looking at the price tag, and that drives my behavior. But I think every day that becomes less and less of a challenge. It’s a matter of how do we communicate with our consumers so that we help them make decisions that ultimately give them the utility that they were looking for in their consumption in the first place?

One of the things, as we talked with stakeholders through this pandemic, is quite interesting. I think the pandemic also shaped a lot of consumer behaviors. Before the pandemic, it was quite clear that aesthetics is the most important thing the consumers are looking for. Does this make me look good?

During and after the pandemic, while that is still important, there were additional questions. Because “Does this make me look good?” And “Does this make me feel safe?” also became questions.

“Does this make me feel good?” we thought was quite interesting because the last thing consumers want is to feel guilty about their consumption. I’m buying this, and I’m destroying the world with this consumption. That doesn’t make me feel good.

How do we have enough transparency and disclosure to help consumers say, oh, peace of mind. Here are the social implications of what you are doing. Here are the environmental implications of your choice. It makes you look good. Maybe you should feel good.

Finally, the utility is also around my relationship to my clothes. Are there some functionalities, high-performance characteristics, that keep me safe or make me have more peace of mind in using these products?

We want to support all of these types of changes with consumers. With the brands, what we are saying is, look, once upon a time, this was a challenge with your CSR department. Five years ago, let’s say. Today, this is a conversation we wanted to have with your CFOs.

Because I think there are going to be clearly winners and losers in this. It’s a zero-sum game. We can’t grow the consumption and volume anymore. In fact, we have to shrink our consumption model. We’re using too much resources. We’re selling too many clothes, and we’re making consumers buy too many clothes.

The only way we’re going to grow, successful brands are going to grow, is by taking market share away from the competitors. And the brands that are part of the solution, the brands that are one of the good guys in these types of challenges of sustainability, probably will be the winners.

You have to really be in that right pack. And therefore this is now a survival, and this is now a growth, and this is now a financial challenge. And you need to invest and put money behind making sure that you’re one of the first movers in this trend. That message resonates well with brands.

Consumers, I think, they are not only price-sensitive—they still are—but I think they are also value sensitive now. How does this make me look? How does this make me feel? What utility am I getting out of this? And I think this is where we can give a more complete solution as consumers consume.

Janet Bush: I just wanted to go back to something you said earlier when you were talking about business models. You were talking about exploring what services that you could provide. I didn’t really understand what that had to do with sustainability. And I just wanted you to explain more about your thinking.

Edwin Keh: A great example and a great experiment we’re doing with that is our Garment-to-Garment Recycle System. This is a retail recycling business. The first store opened in 2019. It’s still operating as a standalone, for-profit.

There, what we’re asking consumers to do is bring your old clothes. And then, at the store, we’ll break them down into fibers. We’ll make yarn out of them. And we’ll take the yarns from your old clothes, and we’ll 3-D knit you new clothes.

So there, we are providing a service. We’ll give you new-looking clothes. You’re just bringing the raw material for it. We have been trying to—not successfully so far, but we’ve approached several designers and said, “Why don’t you sell designs? Why do you have to sell products? Come work with us. Help us program these. We’re not artists. You guys are the designers.”

Right now, if you go into our shop, the question we ask is, “V neck or crew neck?” Because those are the only two things we know how to program. But come help us program some better stuff into our 3-D knitting system. And it’s your design, we’ll put your label on it. And you’re selling the design.

So are there digitized solutions, like that, of selling services? I think there’s a lot of effort to figure out leasing and rental and resale. I don’t think anybody has cracked the code on that. But those types of services are important for us to explore.

And then on the other side of that are predictive analytics. How do we get the right clothes in the right style, in the right color, in the right size, to the right store, at a price that consumers are willing to pay so that we end up making less but selling more?

The profit comes from reducing the dead stock and the inventory risk that a lot of brands are faced with because of this dynamic marketplace that we’re in. It’s harder and harder to use regression analysis, which is most of the systems that buyers are using today. You know, what sold last season is what I want to buy next season.

That doesn’t work when the market is shifting so quickly. And that doesn’t work when you’re trying to expand into another new international market or something like that. So we’ve developed some forward-looking tools, instead of regression. Looking for information out of social media and other peer-to-peer communications. And looking at trend directions, and how things flow from one economy to the other economy. So that we can make more accurate manufacturing and logistics decisions. Those we’re fairly excited about.

Janet Bush: We’ve taken up a lot of your time, and I could go on and on. But I just wanted to finish, if that’s OK, with some very quick-fire questions. My first one is, what makes you the most pessimistic?

Edwin Keh: We’ve touched on it, which is too little, too late. We have short attention spans. We tend to focus on something, but not very long. And unfortunately, things like climate change [are] a long slog that will need decades of focused attention. So that’s a concern.

Janet Bush: What makes you most optimistic?

Edwin Keh: I don’t think that humankind will be extinct because of the fashion decisions that we make. We have, so far, as a species, solved every major challenge that has come along our way. And I know we can do this as well. It’s just getting the right people working on the right problems.

Janet Bush: If you didn’t specialize in retail, fashion, innovation, what would you be doing?

Edwin Keh: Well, first of all, I don’t think I’m a specialist at all. I have a very short attention span. I think that I’m in a great place because this job allows me to explore very broadly. But if I were not doing this, I would probably be very excited to work with some of the social challenges that we see around the world today. And some of the economic opportunities. There are just so many things that don’t require a lot of effort but can yield a lot of results for a lot of people.

Janet Bush: That kind of takes us full circle, because you started working in refugee camps. So that’s where your heart lies?

Edwin Keh: One of the things that you don’t want to happen is, you don’t want to turn 60 and then look back and say, oh, I wish I had done that. I wish. And if that happens to be I wish I had climbed Mount Everest, well, you can’t do it—your knees won’t get you there anymore.

I think we all need to optimize in everything that we do, to say, “How am I going to be most happy? How am I going to be most useful when I look back on things that I’ve spent my time on?”

Making sure that we focus on those, the biggest, the most audacious challenges, will be cool. The geek term for it is, make sure that you don’t have regret avoidance regression analysis.

Janet Bush: On that almost impenetrable note, thank you very much, Edwin. It’s been a real blast.

Edwin Keh: Thank you, Janet.

Dow rallies 400 points as Powell hints Fed could slow pace of rate hikes, Nasdaq jumps 4{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}

Dow rallies 400 points as Powell hints Fed could slow pace of rate hikes, Nasdaq jumps 4{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}

Shares rallied Wednesday following the Federal Reserve declared its substantially predicted .75 share issue rate improve to combat inflation, but hinted that it could sluggish the tempo of its mountaineering campaign at some place.

The Dow Jones Industrial Average jumped 436.05 factors, or practically 1.4{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}, to 32,197.59. The S&P 500 obtained 2.62{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} to close at 4,023.61. The Nasdaq Composite climbed 4.06{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} to 12,032.42. Tech shares led gains a day after quarterly outcomes from Alphabet and Microsoft.

Shares strike their highs of the session in the afternoon as Fed Chairman Jerome Powell left the doorway open up about the sizing of the central bank’s fee move at its subsequent assembly in September and pointed out it would eventually sluggish the magnitude of amount hikes. Powell claimed in a press conference that the Fed could hike by .75 percentage stage yet again in September, but that it would be dependent on the information.

“As the stance of financial policy tightens more, it probably will become suitable to gradual the pace of improves though we evaluate how our cumulative plan adjustments are impacting the economic climate and inflation,” he mentioned.

Investors were being also inspired just after Powell mentioned that he isn’t going to believe that the economy is at the moment in a recession. The 2nd-quarter GDP looking at is thanks on Thursday.

Investors have ongoing to be concerned that the central bank’s ongoing initiatives to reduce inflation will press the financial system into a economic downturn, or that we might previously be in a person. These fears eased Wednesday following Powell said he does not think the U.S. is now in a recession, incorporating that “there are much too many locations of the overall economy that are carrying out way too properly.”

“The purpose this is furnishing some reduction to the equity market place is the Fed is acknowledging that there can be an impression on growth to the economic system based on their plan,” claimed Gargi Chaudhuri, head of BlackRock’s iShares expenditure technique for the Americas. “They are recognizing there are two sides of this: you can find a progress tradeoff to struggle inflation. That recognition is one thing we experienced nowadays that we did not hear ahead of.”

Quite a few regard two consecutive quarters of negative GDP readings as a recession, but the Nationwide Bureau of Financial Research, the official arbiter of recessions, works by using various other things to ascertain 1. The GDP looking through Thursday is envisioned to present hardly an growth just after initial-quarter GDP declined by 1.6{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}.

Shares started the working day on a substantial be aware following finding a improve from tech earnings. Tech stocks extra to people gains as the all round marketplace rallied.

Alphabet shares rose about 7.7{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} right after the tech giant’s quarterly report showed strong earnings from Google’s search business. Microsoft received close to 6.7{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} after reporting a 40{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} bounce in earnings progress for Azure and cloud providers. The gains came even soon after both of those companies posted earnings and revenue that fell beneath analyst estimates.

Meta Platforms shares rose almost 6.6{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}, ahead of its earnings scheduled for right after the bell. Amazon innovative extra than 5{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} following getting hit by the retail carnage Tuesday. Apple included 3.4{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}.

Stores rallied also as inflation fears softened Wednesday afternoon. Walmart, which led retail declines in the former session, climbed about 3.8{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}. Kohl’s, Ross Suppliers and Costco extra much more than 2{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} every single. The SPDR S&P Retail ETF superior approximately 2.6{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}.

Enphase Power also popped on the back of its most recent effects, ending the day about 17.9{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} increased. Chipotle extra 14.7{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} next its combined 2nd-quarter earnings launch.

Lea la cobertura del mercado de hoy en español aquí.

Will today be last home game for two longtime Tigers?

Will today be last home game for two longtime Tigers?

DETROIT — No one is aware of what will come about in the upcoming 7 days, but it’s a rather great bet that Wednesday afternoon will be the final household game for 1 or a lot more Detroit Tigers who are on the buying and selling block in advance of future week’s deadline.

Some of the trade candidates — like veteran reliever Andrew Chafin — just arrived this calendar year and have scarcely had time to unpack their baggage.

MLB trade deadline: 5 Tigers most most likely to be dealt in up coming 7 days

But other individuals, like relievers Michael Fulmer and Joe Jimenez, have deep roots in the business.

“I understand that (Wednesday) is our final household recreation just before the trade deadline, and that may be a minor tricky,” Fulmer explained. “But there is so a lot to be grateful for in this corporation, my teammates, the men in this clubhouse. The Tigers gave me my possibility to begin my occupation. They traded for me when I was 22 yrs old. I’m 29 now. So it’s been a prolonged time and I’m pretty appreciative and grateful for almost everything this firm has performed for me.”

Fulmer will be a totally free agent soon after the period and explained there will be “no really hard emotions whatsoever” if the Tigers trade him ahead of the aug. 2 deadline.

“I know this match is a company and whatever this front business office sees in good shape as getting the most effective go forward for this business, then I’m all for it,” he said.

Jimenez, 27, was signed by the Tigers as an undrafted free of charge agent out of Puerto Rico in 2013. Right after a shaky debut in 2017, he became an All-Star in 2018. There have been additional peaks and valleys along the way, but he’s presently in the midst of a very powerful period, with 49 strikeouts and a 3.13 Era in 37 1/3 innings of operate.

Unlike Fulmer, Jimenez will not be a cost-free agent this winter and has one particular extra 12 months of team control in 2023.

“It’s some thing that you just can’t handle. That’s not on me,” Jimenez explained. “Obviously, I would love to remain right here. I grew up in this article….I’ve been right here considering the fact that I was young. This is all I know.”

The draw back of that familiarity is that the Tigers have not seriously contended for the playoffs given that 2016. So Jimenez has hardly ever had the possibility to pitch in meaningful games down the stretch, significantly a lot less the postseason.

“It would mean a little something different, because I’ve never been there. I haven’t had that knowledge,” he explained. “People say it’s diverse baseball — like the Entire world Baseball Vintage, some thing like that.”

Fulmer as well claims the silver lining of a trade would be a possibility to compete for a postseason spot.

“I necessarily mean, that’s what the trade deadline is about,” he stated. “Usually the fellas that are prospective buyers are profitable teams.”

In the course of Fulmer’s American Rookie of the Yr marketing campaign in 2016, the Tigers competed for a playoff place right up until the final working day of the year.

“I feel I was much too starstruck or in awe that I was in the significant leagues, even at the finish of 2016, that I didn’t definitely recognize how shut we had been to pitching in the playoffs,” Fulmer claimed.

Since then, the Tigers have been between the worst groups in baseball, Fulmer has endured a parade of accidents — such as Tommy John operation — and he made a productive changeover to the bullpen.

Which is why he stated he’s realized to consider this sport day by day and to respect every single day. And today he’s still a Tiger.

Why Tesla’s loyalty rate is ‘ominous’ for the rest of the auto industry

Why Tesla’s loyalty rate is ‘ominous’ for the rest of the auto industry

Even so, Tesla was an exception to the rule. It was a single of a few luxurious brands that didn’t encounter a decrease in loyalty in that time, becoming a member of Maserati and Genesis, which are far more compact brand names when compared with Tesla.

When Tesla is taken out of the calculations, luxury declined by nearly an added share issue, landing at a reduce of 5.5 points to an regular of 45.4 per cent.

“Tesla’s sort of, frankly, hiding a minimal bit of the luxurious decline, which is genuinely two times as substantially as mainstream,” Libby stated in the course of the presentation.

Libby ruled out that Tesla was stealing buyers from other manufacturers.

The firm’s conquest/defection ratio, which exhibits how a lot of clients are defecting to Tesla divided by how quite a few are leaving the brand, was minimal compared with the two luxury and mainstream opponents.

“Tesla’s C/D ratio with the other luxury would make, with the exception of Land Rover, was down, which I discovered surprising. I considered that maybe they were being suffering due to the fact of Tesla,” Libby claimed. “And general mainstream is down also, which I also located a little bit stunning.”

As a substitute of poaching from other makes, Tesla is driving its good results with inner loyalty, he stated.

The Product 3, the company’s dominant nameplate, is powering the trend. The vehicle’s loyalty price jumped by over 7.5 percentage points to an average of 62.2 {cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}.

That usually means about 62 per cent of Product 3 prospects from March 2021 by means of April 2022 currently owned a Tesla car.

Tesla’s 12 months-in excess of-calendar year loyalty amount was even greater. Its March 2022 loyalty amount was 73.1 {cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}, when compared with 49.1 {cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} in March 2021, equaling an maximize of 24 proportion details.

Libby speculated on a couple of distinctive causes for Tesla’s results in light-weight of stock shortages. The distinctive character and manufacturer-creating of CEO Elon Musk is in the vicinity of the prime of the checklist.

“I think he is an terribly gifted marketer. I say that heading way further than the cars and trucks, I feel he is developed an picture of himself and of the brand that truly join with some persons,” Libby said.

Tesla’s array of electrical auto selections could also be playing a aspect, with house owners obtaining obtain to various in-brand segments, these types of as the Model Y crossover.

“The tale right here is that Tesla house owners … they’re coming back again to industry in growing numbers,” Libby mentioned. “But just as essential, if not a lot more crucial, they adore the brand, and they’re acquiring yet another one particular. So this is an ominous, frankly, ominous craze for the rest of the business, a little something that has to be faced, and it has to be acknowledged.”