FDA approves controversial new drug designed to slow the progress of ALS

FDA approves controversial new drug designed to slow the progress of ALS

The Food stuff and Drug Administration on Thursday permitted a controversial new drug developed to gradual the development of Lou Gehrig’s disease, a victory for patients and advocates inspite of confined evidence that the drug is successful.

The drug, from Amylyx Prescription drugs of Massachusetts, joins only a handful of medicine accredited by the agency for the fatal neurodegenerative condition and its indications. 

The illness, also known as amyotrophic lateral sclerosis, or ALS, affects nerve cells desired for activities like walking, speaking and ingesting. There is no identified cure, and most men and women dwell only two to five several years after analysis, according to The ALS Association.

The FDA’s selection was primarily based on a single period 2 clinical demo of 137 ALS individuals that observed folks who took Amylyx’s drug, which will be bought beneath the name Relyvrio, lived about 10 months extended than all those who didn’t. The drug also appeared to hold off hospitalizations. 

The drugs, which will come in a powder, is a mixture of two current products: sodium phenylbutyrate, which is approved to handle a metabolic problem, and taurursodiol, an over-the-counter supplement applied to assist avoid liver illness.

Amylyx explained Friday that Relyvrio will value about $12,500 for a 28-day source, or $158,000 a year just before insurance policies. That’s under the rate of an more mature ALS drug, edaravone, which charges about $170,000 a calendar year. But Relyvrio’s value is however over the Institute for Medical and Economic Review’s advisable price of between $9,100 to $30,700 per calendar year.

The acceptance is possible to spawn some disagreement amid neurologists who address ALS.

Frequently, the Food and drug administration involves at the very least two very well-managed scientific trials to reveal that a drug is efficient or a solitary demo that is “very statistically persuasive,” explained Holly Fernandez Lynch, an assistant professor of medical ethics at the College of Pennsylvania. Amylyx’s trial, she explained, failed to satisfy the agency’s criteria.

Problems about the trial benefits were raised in March, when the drug was first brought before an Fda advisory committee. In briefing documents released ahead of the meeting, company researchers questioned the Amylyx trial’s persuasiveness. The committee voted narrowly against recommending approval.

The Food and drug administration, nonetheless, took the uncommon step of calling for a 2nd advisory committee just six months later, immediately after Amylyx submitted an additional examination of its demo facts. Throughout that meeting, the advisory committee reversed course, voting to propose the drug.

The favorable vote came even with however a further poor review from Food and drug administration researchers, as properly as concerns from various users of the advisory committee about whether or not the scientific demo details provided by Amylyx showed obvious proof that the drug slows the development of the illness.

The agency’s thought of the drug has been in comparison to that of Biogen’s Alzheimer’s drug, Aduhelm. That drug acquired total acceptance from the Fda previous yr, even though the advisory committee voted overwhelmingly against its suggestion, citing a deficiency of proof that it was productive.

Amylyx’s drug approval indicates that the Food and drug administration is inclined to show the utmost flexibility for everyday living-threatening illnesses for which there is an “unmet remedy need,” Lynch stated.

On the other hand, the determination could pose even further problems for the agency, she extra, for the reason that it might not give the company substantially incentive to show that the drug operates.

“It also puts the onus on payers to come to a decision whether or not the proof is enough to aid protection, so in that sense, it may well simply just kick the can,” she mentioned.

Advocates say that whilst questions continue being about the drug’s efficiency, sufferers must be authorized to at minimum attempt it.

“We have to have new remedies as speedily as achievable if we are going to flip ALS into a livable disease and at some point remedy it,” Larry Falivena, a member of The ALS Affiliation, an advocacy group, stated in an email.

Amylyx is jogging a much larger stage 3 medical demo, which it expects to full in late 2023 or early 2024. 

Throughout the September advisory committee conference, company associates agreed to pull the drug from the industry if these demo outcomes showed it was not efficient. The drug has presently been given conditional approval in Canada. 

CORRECTION (Sept. 29, 2022, 9:34 p.m. ET): An previously version of this article misstated how the Amylyx drug is taken. It is taken orally as a powder, not as a pill.

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Bank of England delays bond sales, launches temporary purchase program

Bank of England delays bond sales, launches temporary purchase program

ING: BOE might have to extend bond purchases with ongoing market volatility

LONDON — The Financial institution of England will suspend the planned commence of its gilt promoting next week and start out temporarily obtaining lengthy-dated bonds in buy to calm the sector chaos unleashed by the new government’s so-known as mini-spending plan.

Yields on U.K. authorities bonds, recognised as “gilts,” were being on class for their sharpest every month increase because at the very least 1957 as buyers fled British fastened cash flow marketplaces adhering to the new fiscal policy bulletins. The measures included significant swathes of unfunded tax cuts that have drawn world criticism, which includes from the IMF.

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El-Erian says Bank of England's latest rescue move shows we are still in central bank 'la-la land'

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El-Erian states Bank of England’s newest rescue shift demonstrates we are nevertheless in central bank ‘la-la land’

In a statement Wednesday, the central financial institution mentioned it was checking the “sizeable repricing” of U.K. and worldwide property in new times, which has hit lengthy-dated U.K. authorities debt specially difficult.

“Had been dysfunction in this sector to continue on or worsen, there would be a materials risk to British isles monetary stability. This would lead to an unwarranted tightening of financing disorders and a reduction of the flow of credit score to the serious economic system,” the Lender of England said.

“In line with its economic steadiness objective, the Lender of England stands ready to restore market functioning and lessen any challenges from contagion to credit history problems for United kingdom households and organizations.”

As of Wednesday, the lender will start out non permanent purchases of extended-dated U.K. federal government bonds in get to “restore orderly market place conditions,” and reported these will be carried out “on no matter what scale important” to soothe marketplaces.

Pound could fall even further in the absence of aggressive BOE monetary policy, KCL professor says

The bank’s Economic Plan Committee on Wednesday acknowledged the dysfunction in the gilt industry posed a substance chance to the country’s economic steadiness, and opted to consider speedy action.

The Monetary Policy Committee’s goal of an once-a-year £80 billion ($85 billion) reduction of its gilt holdings continues to be unchanged, the lender reported, with the initial gilt profits — to begin with slated for Monday — now using location on Oct. 31.

A U.K. Treasury spokesperson confirmed that the operation had been “entirely indemnified” by the Treasury and reported that Finance Minister Kwasi Kwarteng is “fully commited to the Financial institution of England’s independence.”

“The Govt will continue to function carefully with the Bank in support of its monetary balance and inflation aims,” the spokesperson additional.

The lender mentioned it will publish a marketplace discover outlining the operational aspects of the plan “soon.”

Yields on U.K. 30-yr gilts and 10-12 months gilts dropped sharply following the announcement, while sterling originally fell 1.5{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} from the greenback in advance of recovering marginally to trade at all-around $1.066 by mid-afternoon in London.

‘Caught in a crossfire’

Antoine Bouvet, senior rates strategist at ING, explained that the Bank of England may need to have to increase the bond purchases beyond the initial two-7 days time period if volatility in the gilt current market continues, and that an supplemental hike in fascination costs was not off the desk.

Bouvet explained to CNBC right away following the announcement that the bank’s first priority for now experienced to be the working of the gilt market, suggesting the worst consequence would be for the sovereign to be left without the need of market access and not able to protected financing.

“Obviously the gilt industry was caught in a crossfire between the Lender of England and the Treasury, and it is not specifically like that but it seemed a whole lot like they were being competing, or working at crossed needs,” Bouvet reported.

“So you have a entire world where you have a economic downturn and the BOE is hoping to awesome the overall economy with hikes, and on the other hand you have the Treasury that is seeking to protect the financial state from that economic downturn and employing fiscal measures that are inflationary.”

He additional that the Treasury’s assertion of assist was vital, noting that the federal government would be eager to keep away from the impact that the gilt industry is in “so significantly hassle” that it experienced compelled the Bank of England to acquire hold of rescuing the economy.

Medical student-led multicultural fundraiser Oct. 10 to celebrate diversity through fashion, dance and music – School of Medicine News

Medical student-led multicultural fundraiser Oct. 10 to celebrate diversity through fashion, dance and music – School of Medicine News
Chinese people dancer Thomas Davis is among the the performers.

Tunes, dance, manner, food and enjoyable are all on the agenda for a student-led fundraiser at Wayne State University that will elevate cash for 482Ahead, a community corporation advocating for education and learning justice for the diverse youth of Detroit.

The WSU School of Medicine’s Globe Overall health Pupil Business will host its first Multicultural Fundraiser at 6 p.m. Oct. 10 in the College student Centre Ballroom. The party will showcase quite a few cultures via a manner clearly show, stay performances and extra.

WHSO Treasurer and Co-Fundraising Chair Mariam Samir, a to start with-12 months professional medical pupil, hopes to make it once-a-year celebration.

“We are hoping to elevate awareness of the issues lots of Detroit youth confront, a section of which stems from a absence of knowing and appreciation of the unique cultures existing. Folks panic what they do not know,” Samir said. “By delivering a platform for folks to depict their society, we are hoping to strengthen cultural appreciation and enhance curiosity and open-mindedness. Additionally, we are aiming to increase money to guide 482Forward in its goals of campaigning for training justice.”

Samir recruited additional university student businesses from the Faculty of Medication to collaborate in the celebration. They consist of the Black Health care Association, Latino Health care Scholar Affiliation, Asian Pacific American Professional medical Scholar Affiliation, Islamic Clinical University student Association, American Affiliation of Medical professionals of Indian Origin and the Nationwide Arab American Healthcare Affiliation.

“When we started searching for a charity, we wanted to select a thing that people today of many cultures can relate to, so we concentrated our consideration regionally,” Samira mentioned. “Detroit is acknowledged for its broad range, and the citizens of Detroit face many systemic troubles. 482Forward makes use of its campaigns to make transform at that degree. One particular of their campaigns, for instance, was changing laws to put extra money toward psychological well being in universities. Aside from mental health and fitness, they also target on trauma, social determinants of wellness and adverse childhood activities, trauma-knowledgeable treatment, immigration justice in schools and language in colleges.”

The celebration is open up to all and will include remarks from Faculty of Drugs Dean Wael Sakr, M.D., a 50-50 raffle, raffles for henna tattoos by nearby artists, and Center Eastern-impressed meals.

Performers consist of Kpop, Chinese folk and Latino dance teams based at WSU guitarist and second-12 months professional medical student Hassan Ahmad, who will engage in Bollywood and South Asian-encouraged music and a spoken phrase overall performance by Assistant Professor of Interior Medicine-Pediatrics Ijeoma Nnodim-Opara, M.D. ’08, Res. ’12.

The fashion clearly show will spotlight outfits from 5 areas, like Pacific Asian, South Asian, Middle-Jap, African/African American/Diaspora and South American/Latino.

Students exciting in modeling in the fashion display may indication up at https://varieties.gle/7jixmPdaftU5Z8s36.

Passion, exercise, and relationships protect against cognitive decline

Passion, exercise, and relationships protect against cognitive decline

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In a recent paper, researchers reviewed studies linking three key lifestyle factors to brain health. Mint Images RF/Getty Images
  • In a recent paper, researchers reviewed studies linking exercise, relationships, and passion to brain health.
  • They found reasonable evidence that all three factors offer protection against cognitive decline.
  • Their review noted that randomized controlled trials are needed to confirm their findings.

Changes to cognitive function during the aging process are related to the brain’s white and gray matter volume.

Gray matter consists of biological structures, including neuronal cell bodies, synapses, and capillaries, whereas white matter consists of myelinated axons, through which signals are carried between neurons.

Gray matter volume steadily declines at around 10 years of age. Research suggests that medically and cognitively healthier individuals experience less brain atrophy than less healthy individuals.

Studies also show that regular exercise, strong relationships, and passion are key to maintaining a healthy brain during the aging process.

In a recent paper, researchers performed a thorough review of the extensive body of literature available on the link between brain physiology development, and physical activity, social relationships, and passion. Based on the evidence, they report that increased passion for an area or skill leads to more physical activity, more social relationships, and better well-being.

“[From our research], we have found that passion- or strong interest- may be a [key motivational factor for achievement and well-being] as it sets the direction of the arrow,“ Hermundur Sigmundsson, Ph.D., professor of psychology at the Norwegian University of Science and Technology, the lead author, told Medical News Today.

“Therefore, we say: Find your passion and develop it! Grit, or perseverance, is the size and strength of the arrow. Find your interest area and focus on the process. [Be ready to] take challenges! Challenges are key for development!” he added.

The paper was recently published in a special issue of Brain Sciences.

Observational studies indicate that an active lifestyle is helpful for maintaining cognitive and neurological health across age groups — especially in higher order processes such as switching between tasks, working memory, and cognitive inhibition.

The researchers noted in their paper that intervention studies had confirmed these findings.

For example, older adults who underwent 1 hour of aerobic training 3 times per week for 6 months had increased gray and white matter volume compared to controls.

Other research shows that physical activity increases functionality in brain areas linked to attention and attention control, daily life activities, and cognitive reserve, a reserve of thinking abilities that acts as a buffer against age-related cognitive decline.

The new paper points to studies that suggest that maintaining social ties enhances cognitive reserve through cognitive strategies, greater neural growth, and synaptic density, which protect against pathological processes.

Imaging studies have demonstrated that larger social networks are linked to a larger orbitofrontal cortex — involved in decision-making — and amygdala volume.

These studies also demonstrate that less socially active people have a greater number of white matter lesions.

In addition, randomized control trials have shown that social relations may enhance cognitive reserve, and interventions have shown that increased social interaction in communities is linked to better cognitive function and larger brain volume.

Other studies, however, indicate no link between social relations and cognitive function later in life. The researchers thus suggest that more robust evidence from randomized controlled trials is needed to demonstrate causality.

In their paper, the researchers defined passion as “a strong feeling toward a personally important value/preference that motivates intentions and behaviors to express that value/preference.”

Other research has found that passion is related to more deliberate practice among football players and better well-being and performance among workers.

The researchers also noted that passion might thus be important for maintaining neural plasticity. They wrote: “…hence repetition, use it or lose it, use it and improve it and intensity.”

An example of this is someone who is passionate about learning new languages. The researchers wrote that passion could motivate an individual to practice the second language more and thus strengthen their gray matter, neural cells, and connections.

They also noted that psychological traits such as grit and a growth mindset have also been linked to the development of gray matter in different parts of the brain.

The researchers further cited a number of articles that suggest impaired motor function, antisocial behavior, depression, and anhedonia (the inability to feel pleasure) are common in neurodegenerative and psychiatric disorders and in the natural aging process.

They thus suggested that a “vicious cycle” may be at play: less physical activity may promote less social engagement and lower well-being.

“Passion gives direction to the area of interest, which could be related to the dopamine system, which is central in attention, learning, goal-directed behaviors, and rewards. Passion may be providing the focus essential for long-term goal achievement,” wrote the researchers.

When asked how physical activity, socializing, and passion improve brain health, Art Kramer, Ph.D., professor emeritus in the department of psychology at the University of Illinois Urbana-Champaign, not involved in the research, told MNT:

We know more about the mechanisms that underlie physical activity than social interactions or learning novel skills since there is a multi-decade literature on physical activity effects on brain health and learning and memory because there are excellent animal models for physical activity (often wheel running with rodents).”

“The animal literature suggests a number of brain changes associated with physical activity, including new neurons in brain regions that support memory, more connections among neurons (called synapses), and increases in vascular structure. Increases in neurotransmitters and nerve growth factors (among other changes) have also been associated with increases in physical activity in animal models.”

– Art Kramer, Ph.D., professor emeritus at the University of Illinois Urbana-Champaign

The researchers concluded that physical exercise, social interactions, and passion are key to maintaining brain health.

When asked about the paper’s limitations, Dr. Sigmundsson noted that their article is just a review and that intervention studies focusing on increasing passion, physical activity, and social engagement need to be carried out to confirm their hypotheses.

Dr. Kramer added: “There are a number of limitations, including how best to personalize these factors to enhance cognitive and brain function in individuals as well as how best to combine intellectual engagement, physical activity and social interactions to maximize their benefits across the lifespan and with non-patients and patients alike.”

Today in the Connected Economy: Snap’s AR Fashion

Today in the Connected Economy: Snap’s AR Fashion

Right now in the related economy, executives at Snap point to their augmented actuality apparel and trend offerings as  a virtual alternate to the metaverse.

Also, Dubai actions up its attempts to turn out to be the world’s metaverse funds, and Robinhood teams with Circle to enhance entry to USD Coin.

Snap Luxury Boss: Augmented Reality Is the Long run of Manner

Snap’s head of luxurious is marketing the likely of augmented actuality (AR) to clothing and other branded items.

Snap’s Geoffrey Perez made the remarks all through the Bloomberg Technological know-how Summit in London, while wearing a pair of his company’s AR eyeglasses.

“Every day we have 250 million people engaging with augmented actuality on our platform,” he explained. “Not just to test attire on, but also jewellery and make-up. This is how we see engaging with the true environment in the upcoming.”

Dubai Ramps Up Attempts to Develop into International Metaverse Money

As essential players arrive at the Dubai Metaverse Assembly, the money metropolis of the United Arab Emirates (UAE) is hoping declare the title of planet metaverse capital at a time when the principle is increasing recognition all-around the entire world.

The conference follows a different celebration in the city — Metavision — which saw some of Dubai’s prime officials meet with personal sector stakeholders to focus on subject areas ranging from cryptocurrency to non-fungible tokens (NFTs), experiential commerce, how governments should get ready for the metaverse and the melding of the actual physical and electronic worlds.

In his remarks at Metavision, Marwan Alzarouni, CEO at Dubai Blockchain Center, stated that “Whoever controls the metaverse will handle the entire world,” an sign of just how substantial the stakes are perceived to be by these in the sector.

Circle, Robinhood Lover to Simplify, Increase Use of USDC

Circle Web Fiscal, which issues USD Coin (USDC) and Euro Coin (EUROC), is collaborating with Robinhood to make it a lot easier for clientele to master about and use USDC.

Buyers on Robinhood Crypto and the new Robinhood Wallet can now buy, promote and get USDC via the partnership.

“The launch of USDC on a celebrated buyer platform like Robinhood reinforces the job USDC plays in larger payments and commerce use cases,” mentioned Circle Co-Founder and CEO Jeremy Allaire. “Through this partnership, we glimpse ahead to jointly introducing [Web3] to a new technology of tech-savvy and digitally linked people today.”

Lavu, Parafin Spouse to Present Dining places Funds Advancements

Restaurant software package and payments platform Lavu has unveiled a new resource that gives eating places income innovations.

The new Lavu Capital item is powered by embedded FinTech organization Parafin and provides places to eat “easy obtain to fast capital,” the businesses stated in a news launch.

“It’s frustrating to see how a lot of cafe entrepreneurs do not qualify for regular loans in spite of their sturdy monitor documents,” Lavu CEO Saleem Khatri mentioned. “In the identical way we served 1000’s of dining places rapidly transition to on-line ordering to survive the pandemic, we are launching Lavu Money to support more eating places retain their doorways open up all through difficult instances.”

Companion Hub, Answer Spend Workforce on eInvoicing, Ask for-to-Shell out Solutions

Payments-as-a-assistance platform Reply Pay back and on line invoicing services and engineering firm Spouse Hub have teamed up to make it simpler for banks to provide clients ask for-to-pay and eInvoicing providers.

The collaboration marries Response Pay’s request-to-fork out support and Lover Hub’s skill to reformat invoice facts from organization useful resource scheduling (ERP) systems for invoice presentation and automatically deliver payment requests in excess of Solution Pay’s request-to-spend networks.

“With our [eInvoice] alternative, the two most significant banks in Hungary had been able to speedily and securely get up and jogging,” Spouse Hub Co-Founder Katalin Kauzli explained. “We’re wanting forward to operating with Respond to Pay out to assistance financial institutions in the rest of Europe consider entire benefit of this strong combination of [eInvoicing] and [request-to-pay].

PingPong, Uncapped Associate on Capital Advance for European Retailers

In a bid to assistance eCommerce merchants that want to grow, PingPong Payments and Uncapped are working alongside one another to assistance PingPong clients in Europe to get a capital advance from Uncapped.

The settlement for lending solutions provides with each other the customers of PingPong’s conclusion-to-end payment solutions for cross-border enterprises with Uncapped’s profits-dependent funding that can enable finance their on line enterprises.

“With Uncapped, PingPong is bringing a significant offer to PingPong customers for them to acquire rapid funding supports, which would be a critical to their commercial success in the eCommerce globe,” PingPong Europe Managing Director Chunhe Zhang claimed in a information launch. “The partnership is a milestone signifying PingPong’s new steps to whole scope providers for eCommerce sellers in Europe.”

New PYMNTS Review: How Consumers Use Electronic Banking institutions

A PYMNTS survey of 2,124 US consumers displays that whilst two-thirds of people have utilized FinTechs for some facet of banking companies, just 9.3{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} contact them their major bank.

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We’re normally on the lookout for alternatives to husband or wife with innovators and disruptors.

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Hospitals often reap profits in places where many patients carry medical debt : Shots

Hospitals often reap profits in places where many patients carry medical debt : Shots

Aerial view of downtown Fort Worth, Texas. Some hospitals in Texas and around the U.S. are seeing high profits, even as their bills force patients into debt. Of the nation’s 20 most populous counties, none has a higher concentration of medical debt than Tarrant County, home to Fort Worth.

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Aerial view of downtown Fort Worth, Texas. Some hospitals in Texas and around the U.S. are seeing high profits, even as their bills force patients into debt. Of the nation’s 20 most populous counties, none has a higher concentration of medical debt than Tarrant County, home to Fort Worth.

Jupiterimages/Getty Images

PROSPER, Texas — Almost everything about the opening of the 2019 Prosper High School Eagles’ football season was big.

The game in this Dallas-Fort Worth suburb began with fireworks and a four-airplane flyover. A trained eagle soared over the field. And some 12,000 fans filled the team’s new stadium, a $53 million colossus with the largest video screen of any high school venue in Texas. Atop the stadium was also a big name: Children’s Health.

Business has been good for the billion-dollar pediatric hospital system, which agreed to pay $2.5 million to put its name on the Prosper stadium. Other Dallas-Fort Worth medical systems have also thrived. Though exempt from taxes as nonprofit institutions, several, including Children’s, notched double-digit margins in recent years, outperforming many of the area’s Fortune 500 companies.

But patients aren’t sharing in the good times. Of the nation’s 20 most populous counties, none has a higher concentration of medical debt than Tarrant County, home to Fort Worth. Second is Dallas County, credit bureau data show.

The mismatched fortunes of hospitals and their patients reach well beyond this corner of Texas. Nationwide, many hospitals have grown wealthy, spending lavishly on advertising, team sponsorships, and even spas, while patients are squeezed by skyrocketing medical prices and rising deductibles.

A KHN review of hospital finances in the country’s 306 hospital markets found that several of the most profitable markets also have some of the highest levels of patient debt.

Overall, about a third of the 100 million adults in the U.S. with health care debt owe money for a hospitalization, according to a poll conducted by KFF for this project. Close to half of those owe at least $5,000. About a quarter owe $10,000 or more.

Many are pursued by collectors when they can’t pay their bills or hospitals sell the debt.

“The fact is, if you walk into a hospital today, chances are you are going to walk out with debt, even if you have insurance,” said Allison Sesso, chief executive of RIP Medical Debt, a nonprofit that buys debt from hospitals and debt collectors so patients won’t have to pay it.

A community shadowed by debt

Across the Dallas-Fort Worth metro area — the nation’s fourth-largest — the impact has been devastating.

“Medical debt is forcing people here to make incredibly agonizing choices,” said Toby Savitz, programs director at Pathfinders, a Fort Worth nonprofit that assists people with credit problems. Savitz estimated that at least half their clients have medical debt. Many are scrimping on food, neglecting rent, even ending up homeless, she said, “and this is not just low-income people.”

David Zipprich, a Fort Worth businessman and grandfather, was forced out of retirement after hospitalizations left him owing more than $200,000.

Zipprich, 64, had spent a career in financial consulting. He owned a small bungalow in a historical neighborhood near the Fort Worth rail yards. His daughters, both teachers, and his four grandchildren lived nearby. He had health insurance and some savings, and he’d paid off his mortgage.

Then in early 2020, Zipprich landed in the hospital. While driving, his blood sugar dropped precipitously, causing him to black out and crash his car.

Three months later, after he was diagnosed with diabetes, another complication led to another hospitalization. In December 2020, covid-19 put him there yet again. “I look back at that year and feel lucky I even survived,” Zipprich said.

David Zipprich, a Fort Worth financial consultant and grandfather, was forced out of retirement after hospitalizations left him owing more than $200,000.

Laura Buckman for KHN and NPR


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Laura Buckman for KHN and NPR


David Zipprich, a Fort Worth financial consultant and grandfather, was forced out of retirement after hospitalizations left him owing more than $200,000.

Laura Buckman for KHN and NPR

But even with insurance, Zipprich was inundated with debt notices and calls from collectors. His credit score plummeted below 600, and he had to refinance his home. “My stress was off the charts,” he said, sitting in his neatly kept living room with his Shih Tzu, Murphy.

Overall in Tarrant County, 27{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of residents with credit reports have medical debt on their records, credit bureau data analyzed by KHN and the nonprofit Urban Institute shows. In Dallas County, it’s 22{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}.

That’s more than five times the rate in the largest counties in New York, data shows. The Texans also owe a lot more — the median amount of medical debt on credit records in Tarrant and Dallas counties is nearly $1,000, compared with $400 or less in New York.

Last year, Zipprich returned to work, taking a job in New Jersey that required he commute back and forth to Texas. He recently quit, citing the strain of so much travel. He’s now job hunting again. “I never thought this would happen to me,” he said.

Who is responsible?

Even small debts can have potentially dangerous consequences, discouraging patients from seeking needed care. Angie Johnson, a 28-year-old schoolteacher, cut short her honeymoon so she and her husband could pay off more than $1,100 she owed a physical therapy center owned by Baylor Scott & White, a mammoth Dallas-based hospital system.

Johnson said the center, where she’d gone after a knee injury, initially said her visits would cost $60. “Then they billed me hundreds,” she said. “I don’t go to the doctor unless I absolutely have to because it’s so expensive.”

Angie Johnson of Waxahachie, Texas, says the physical therapy center she went to after a knee injury initially told her visits would cost $60. “Then they billed me hundreds,” she says.

Laura Buckman for KHN and NPR


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Laura Buckman for KHN and NPR


Angie Johnson of Waxahachie, Texas, says the physical therapy center she went to after a knee injury initially told her visits would cost $60. “Then they billed me hundreds,” she says.

Laura Buckman for KHN and NPR

Hospital industry leaders blame the patient debt on health insurers, citing the rise of high-deductible plans and other efforts that limit coverage. “The last thing that hospitals want is for their patients to face financial barriers,” said Molly Smith who leads public policy at the American Hospital Association. “Hospitals are in there trying to work on behalf of patients.”

Despite repeated requests from KHN, none of the medical systems around Dallas-Fort Worth would discuss their finances or the debt carried by patients.

But Smith and other hospital leaders point to billions of dollars of free or discounted care that hospitals nationwide provide every year. “Hospitals have been pretty darn generous,” said Stephen Love, president of the Dallas-Fort Worth Hospital Council. “If other parts of the community did as much as hospitals, we wouldn’t be in this problem.”

Unlike drug companies, device makers, and many physician practices, most U.S. hospitals are nonprofit and must provide charity care as a condition of their tax-exempt status.

Regardless of tax status, medical centers in markets with high medical debt do provide more charity care, according to an analysis by KHN and the Urban Institute, a Washington think tank. That’s important, said Dr. Vikas Saini, president of the Lown Institute, a nonprofit that grades hospitals on their quality and community benefits.

But Saini asked: “Is a hospital truly serving its community if it’s pushing so many into debt?”

Around Dallas-Fort Worth, major medical systems frequently tout their commitment to the region and its patients.

When Texas Health Resources, a Dallas-based nonprofit system with more than $5 billion in annual revenue, opened a new hospital tower in Fort Worth earlier this year, Barclay Berdan, the system’s chief executive, said the building “reinforces Texas Health’s long-standing commitment to the Fort Worth community.” The nine-story, $300 million tower is one of more than a half-dozen new hospitals and major expansions around the Dallas-Fort Worth area since 2018.

The big building spree has been accompanied by big bottom lines.

From 2018 to 2021, Texas Health, which owns hospitals in North Texas, had an average operating margin of almost 6{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}, according to a KHN analysis of publicly available financial reports.

Other major systems in the area, including Baylor, Children’s Health, and HCA, the nation’s largest for-profit hospital company, did even better, KHN found. Cook Children’s, the region’s second major pediatric system, had an average operating margin of nearly 12{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}.

By comparison, profits at most of the 25 Fortune 500 companies based around Dallas-Fort Worth, such as ExxonMobil, were less than 6{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} in 2019, according to Fortune data.

Approaching a tipping point

Hospitals have thrived in other markets with high patient debt, KHN found.

In Charlotte, N.C., where a quarter of residents have medical debt on their credit reports, hospitals recorded an average operating margin of 13.6{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} from 2017 to 2019.

The average margin at hospitals in and around Gainesville and Lakeland, two central Florida markets where a quarter of residents also carry medical debt, topped 9{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}. In Tulsa, Okla., which has the same level of debt, margins have averaged 8.5{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}.

Overall, U.S. hospitals recorded their most profitable year on record in 2019, with an aggregate operating margin of 6.5{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}, according to the federal Medicare Payment Advisory Commission. Total margins, which include income from investments, were even higher.

“You might think that hospitals in communities where patients have a lot of debt would be less profitable, but that doesn’t seem to be the case,” said Anuj Gangopadhyaya, a senior Urban Institute researcher who worked with KHN on an analysis of hospital finance and consumer debt data in U.S. hospital markets.

In fact, the analysis found, there is no apparent relationship between the profits of hospitals in a market and how much medical debt residents have. So while hospitals in places like Charlotte and Tulsa may be comfortably in the black, in other places with high patient debt such as Amarillo, Texas, and Columbia, S.C., hospitals are struggling, data shows.

Industry experts say the most profitable medical centers — like those around Dallas-Fort Worth — have developed business models that allow them to prosper even if their patients can’t pay.

One key is prices. These hospitals maximize what they charge for everything from a complex surgery to a dose of aspirin. Most of those charges are picked up by health insurers, which still pay a much larger share of hospital bills than patients do, even those with the highest deductibles.

Across the country, many medical systems have strengthened their market power in recent years by consolidating, buying up smaller hospitals and physician practices, which enable the hospital systems to charge even more.

Dallas-Fort Worth has the highest medical prices in Texas, according to the Health Care Cost Institute, a nonprofit that tracks costs nationwide. And in a state where most markets have relatively low medical prices, in-patient care at Dallas-Fort Worth hospitals was 13{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} more expensive than the national median in 2020.

In addition to charging more, the most profitable hospitals frequently squeeze more savings from their operations, holding down what they pay workers, for example, and securing better contracts from suppliers. “Hospitals have had to get leaner and meaner,” said Kevin Holloran, a senior director at Fitch Ratings who tracks nonprofit health systems for the bond rating firm.

It’s unclear how much longer this business model can endure.

Across the country, many small and rural hospitals have closed in recent years. Even some larger systems are now losing money, as inflation and rising labor costs put new pressure on bottom lines.

As bills rise, hospitals are having a harder time collecting. Last year, nearly 1 in 5 patient bills generated by hospitals for people with insurance topped $7,500, according to an analysis of hospital billing records by Crowe LLP, a Chicago-based accounting and consulting firm. That was more than triple the rate in 2018.

“These are bills that fewer and fewer patients out there can afford,” said Brian Sanderson, a senior Crowe health care consultant and former hospital executive. Indeed, hospitals manage to collect less than 17{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of patient balances that exceed $7,500, according to Crowe’s analysis.

“The rates at which patient balances are growing is just unsustainable for our health systems,” Sanderson said, predicting that most will never be able to collect bills of this size. “It’s trending to the ridiculous.”

Robert Earley, a former Texas state legislator who used to head Fort Worth’s public health system, compared today’s hospitals to shrimpers in the Gulf Coast district he once represented.

“They wanted to pull so much shrimp out of the bay that they didn’t think about whether there’d be any there long term,” Earley said, recalling his constituents’ struggles. “I worry that those of us in health care aren’t asking ourselves enough if this system is sustainable.”

Diagnosis: Debt is a reporting partnership between KHN and NPR exploring the scale, impact, and causes of medical debt in America.

KHN (Kaiser Health News) is a national newsroom that produces in-depth journalism about health issues. It is an editorially independent operating program of KFF (Kaiser Family Foundation).