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February 13, 2022

Is daily word puzzle the same now New York Times owns it?

The popular on line phrase puzzle video game Wordle has attracted hundreds of thousands of players in current weeks.
As fascination in Wordle grew, The New York Times paid out creator Josh Wardle “very low 7 figures” for the match.
With Wordle’s attractiveness, new offshoots of the original recreation have arisen which includes an archive and a math alternative.

Wordle has only been element of our on line life for a couple weeks but for a lot of, the common puzzle video game has turn out to be a bona fide T-H-I-N-G.

Produced by New York software package engineer Josh Wardle, who released the sport in fall 2021, Wordle’s participating in viewers skyrocketed from only 90 on Nov. 1 to 2 million by mid-January, Wardle told TechCrunch.

The aim of the free-to-engage in video game: Guess the hidden 5-letter term within just six tries. With every try, any accurate letter you get shows up in a eco-friendly sq. if it really is in the suitable position. Letters show up in a yellow sq. if they are in the term but you haven’t guessed their proper placement. Any letter not in the phrase receives a gray square.

As interest in the recreation grew, gamers started posting their benefits on Twitter and Facebook, which helped appeal to additional players – and draw scorn from non-players bitter about the viral unfold of Wordle results posts in their social feeds.

Then, The New York Instances on January 31 reported it paid out the game’s creator a selling price “in the lower seven figures” to obtain the recreation.

Wordle:3 tips to mastering the viral phrase recreation

Wordle score is criminal offense clue:An 80-calendar year-aged mom failed to share her Wordle rating. It could have saved her daily life.

Does it charge me to enjoy Wordle?

No. At the very least not yet. A tweet from the NYTimes Wordplay account reported: “The match will nonetheless be free of charge.”

On the other hand, in its story saying the acquisition, The New York Times stated the sport “would to begin with remain no cost to new and present players.”

That indicates a feasible “expiration day” on the game’s free of charge-to-perform standing, wrote Paul Tassi, Forbes’ senior contributor for online games.

The Situations will have to weigh the advantages and negatives of building gamers spend.

“You place it in a paywall and then individuals will fork out to engage in it,” he wrote. “But in the course of action, you would be carving out an astronomical total of its users, and offing 1 of its most important appeals, its ease of entry, as it is just an incredibly essential browser game that can be accessed instantly and from anyplace.”

Some gamers on Twitter decried the transaction. “I was waiting for our Wordle enjoyable to be ruined by a massive business, just like every thing else,” wrote a user who works by using the Twitter cope with @loveholliejo. “And in this article it is. It was good although it lasted.”

But other individuals congratulated Wardle, who instructed The Instances he developed the sport for his lover who enjoys word game titles. “That’s a life-transforming sum of revenue,” tweeted user @Felgraf_Physicsone. “I wouldn’t be able to blame you even if they said they were being gonna monetize it Instantly. You made a point, men and women savored it for free for a whilst, you have and experienced no obligation to continue to keep performing that.”

Will Wordle nonetheless monitor my scores? Has the video game adjusted?

That is the plan. But when the match moved to the nytimes.com website Thursday, some people did not see their streaks and other statistics on participating in the sport.

Times’ spokesperson Jordan Cohen instructed The Verge on Friday that streaks and stats “must be carried in excess of for” most players, but “we are viewing some reports of end users continuing to have challenges, and are investigating and participating with these customers.”

One obvious change in the match is the phasing out of filthy words, which helps make sense now that The Occasions owns the game.

“Offensive phrases will constantly be omitted from thought,” the outlet told Polygon. “As we have just began Wordle’s transition to The Moments site, we are nonetheless in the process of taking away those people terms from the sport play.”

Wordle recommendations:This is the very best commencing term to use to participate in Wordle, according to a math professional

What is actually everybody chatting about? Indication up for our trending newsletter to get the newest news of the day

What is the Wordle internet site?

Initially, Wordle was hosted on the powerlanguage.co.uk world wide web deal with. Wardle acquired the title, he advised TechCrunch, just after a person termed him and mates out for making use of foul language, but they misheard it as “energy language.”

Its new dwelling is on The Moments web-site (https://www.nytimes.com/games/wordle/index.html). Soon after the initial trouble with gamers not viewing their stats when they played the activity, The Occasions inspired players to use the authentic Wordle URL and enable the recreation redirect them to the new Moments-housed website page.

What is the Wordle Archive?

If you are a modern convert to Wordle, there is certainly now a way to go again and engage in before puzzles, thanks to Devang Thakkar, a Ph.D scholar at Duke College university student who developed a Wordle Archive of earlier puzzles.

Wordle refreshes its puzzle everyday, so if you miss out on one particular, earlier you ended up out of luck. Thakkar stated on Twitter he “like a good deal of people today on this web page, enjoy my everyday Wordles. But if you ignore to do one particular, there is no way to go back to it. So I resolved to make a single.”

As of Saturday (Feb. 12), there have been 238 Wordle puzzles. On Thakkar’s Wordle Archive site, you can participate in all of them.

Obsessed with Wordle?:Below are 10 equivalent games to play

Are there other games like Wordle?

You only get 1 Wordle just about every 24 hours, so how do you remain occupied the relaxation of the day? Well, Usa Present-day Brett Molina uncovered 4 online games similar to Wordle, which could strike your F-A-N-C-Y.

Amongst them is a person that may specifically curiosity admirers of the will work of J.R.R. Tolkien: Lordle of the Rings. The sport also uses five-letter phrases but they occur from the principal textual content of Lord of the Rings.

And need to you overlook all those soiled terms becoming phased out of Wordle, there’s Lewdle, which performs like Wordle but utilizes only lewd language.

The newest obvious perform on Wrdle is Quordle, which has you try to reveal four – of course, four – words at the very same time. Luckily, you do get a total of nine attempts to accomplish that.

Term about the recreation was trending this weekend on Twitter. Ahmir-Khalib Thompson, better recognized as Questlove, even chimed in on the social network “You wanna see who’s terrible? Solve Four wordles simultaneously,” tweeted the founder of the Roots and director of “Summertime of Soul (Or, When the Revolution Could Not Be Televised)”.

February 13, 2022

After Covid, risks of heart problems remain elevated for up to a year

As considerably as Michelle Wilson understood, she’d recovered from Covid-19.

Wilson, 65, contracted the virus in November 2020. Her disease, she reported, was delicate, and she was experience ready to go back to perform as a nurse in St. Louis by early December.

Comprehensive coverage of the Covid-19 pandemic

That is when her heart troubles started.

“I virtually woke up a person morning, and my heart was racing and beating erratically,” Wilson recalled. “I was acquiring intensive chest agony.”

Fortunately, Wilson was not acquiring a coronary heart attack. But she did acquire long-expression heart problems, which include higher blood tension, placing her at chance for further cardiovascular issues.

Inspite of her age, she experienced no prior clinical record to counsel she was at threat for heart disease — other than Covid-19.

Without a doubt, it appears the coronavirus can go away clients at threat for coronary heart challenges for at the very least a single yr pursuing infection, in accordance to a person of the largest analyses of post-Covid well being results to date.

The research, released final week in Mother nature Drugs, uncovered that the illness amplified the possibility of heart rhythm irregularities, as nicely as likely fatal blood clots in the legs and lungs, in the year just after an acute infection.

Covid also enhanced the chance for heart failure by 72 per cent, coronary heart attack by 63 {cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} and stroke by 52 per cent — even between individuals, like Wilson, whose first health problems ended up gentle.

The study’s lead creator, Dr. Ziyad Al-Aly, a clinical epidemiologist at Washington College in St. Louis, explained he and his colleagues envisioned to see some elevation in heart challenges subsequent Covid, but assumed it would be constrained mainly to persons whose overall health was not sturdy formerly.

The elevated chance remained when scientists accounted for age and race, he stated.

“It was a bit of a moment for us when we realized it was apparent in all of these subgroups,” Al-Aly said, “such as younger grownups, more mature grown ups, Black people today, white people today, persons with being overweight and people with out.”

“The possibility was everywhere you go,” he reported.

Al-Aly’s crew examined the prices of new heart challenges amid 153,760 Covid sufferers for up to a calendar year next their disease. The contributors have been people who’d sought treatment within the Office of Veterans Affairs, and most had been white males.

Cardiovascular results were when compared to two control teams: 5.6 million individuals without having Covid, and one more 5.9 million patients whose data was gathered just before the pandemic commenced.

Covid-19 individuals in this examine were contaminated ahead of vaccines had been accessible, so it is unclear how the photographs could alter the findings.

But medical professionals on the entrance strains of treating Covid and its effects suspect vaccinations do reduce heart dangers due to the fact they lessen Covid bacterial infections in basic.

“I have taken care of people with coronary heart challenges” following Covid-19 infection, stated Dr. Steve Nissen, a cardiologist at the Cleveland Clinic. “The huge the vast majority are unvaccinated.”

Down load the NBC News app for whole coverage of the Covid-19 pandemic

That Covid-19 seems to enhance very long-phrase pitfalls of cardiovascular troubles is not stunning to health professionals. Other viruses, this sort of as influenza and selected enteroviruses, have lengthy been known to carry the identical pitfalls.

“Any person who is hospitalized with any form of pneumonia that they receive in the local community has these challenges for six to 12 months,” claimed Dr. Donald Lloyd-Jones, president of the American Heart Affiliation. “The open dilemma for me is, is this a thing unique about Covid? Or is this the exact same tale we by now know?”

Covid’s coronary heart pitfalls may be demonstrating up with extra regularity just since the virus unfold so rapidly.

“It can be extremely regarding since so lots of men and women will be having Covid in the following even so a lot of a long time, and so lots of have currently gotten it,” stated Dr. Jennifer Haythe, co-director of the Women’s Middle for Cardiovascular Health and fitness at the Columbia University Irving Medical Centre in New York. “This may definitely enhance the burden of cardiovascular condition across the board.”

Al-Aly’s investigate is not the very first to counsel lengthy-term coronary heart threats subsequent Covid-19.

A examine of recovered Covid people in Germany uncovered that 78 {cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of individuals experienced heart abnormalities. Swedish investigation, way too, found an elevated risk of coronary heart attack and stroke subsequent Covid-19.

It is not solely crystal clear how Covid could result in heart difficulties above the very long time period, nevertheless it is recognised that the virus can have an effect on blood vessels all more than the entire body and in multiple organs, which include the heart.

For Wilson, the irregular heartbeat has endured.

She has experienced to rest just about upright for months.

“It obtained so undesirable that when I laid down, I couldn’t rest mainly because my coronary heart was so erratic,” she mentioned.

Her physicians are now monitoring her for any indicator of heart failure.

Regardless of infection, the pandemic by itself is also upping the chance of coronary heart wellness issues.

“Too lots of patients are delaying getting back into their regimen in just the well being care process,” Lloyd-Jones reported. “We have witnessed marked raises in overall blood pressure degrees, weight get, worsening command of diabetes, and all of those people issues are contributing to greater possibility.”

Any one whose Covid recovery stalls, or who ordeals a sudden onset of new signs, these types of as upper body soreness, powerful muscle mass weak spot or shortness of breath, should call 911 straight away, Lloyd-Jones claimed.

All those usually are not just pink flags, he explained. “These are flashing lights.”

Follow NBC Health on Twitter & Facebook.

February 13, 2022

Aditya Birla Fashion & Retail Limited Latest Share News | ABFRL | Stock News Today | Oakland News Now

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February 13, 2022

Canadian ‘Freedom Convoy’: TD Bank freezes accounts with $1.1M for trucker protest

FOX Business’ Jeff Flock talks to a Canadian truck driver who states the Freedom Convoy motion is much more than just truckers.

Toronto-Dominion Lender froze two individual bank accounts, one particular of which included C$1.4 million ($1.1 million), to aid “Freedom Convoy” protesters in Canada who are pushing back again versus vaccine mandates and other COVID-19 techniques.

‘FREEDOM CONVOY’: PROTESTERS Obtain AT BUFFALO PEACE BRIDGE In the vicinity of US-CANADA BORDER

The final decision to freeze the accounts was confirmed by a spokesperson for the financial institution in a assertion, in accordance to a report from Reuters.

Vehicles of the protest convoy are seen parked on the Sir John A. Macdonald parkway leading in to downtown Ottawa on Sunday, Jan. 30, 2022.

Automobiles of the protest convoy are noticed parked on the Sir John A. Macdonald parkway primary in to downtown Ottawa on Sunday, Jan. 30, 2022. (Adrian Wyld/The Canadian Push by way of AP / AP Newsroom)

The move, according to the statement, arrived following TD utilized to the Ontario Top-quality Court of Justice this 7 days about taking resources despatched as a result of bank transfers and GoFundMe and giving them to the supposed recipients or returning them to the donors “who have asked for refunds but whose entitlement to a refund cannot be determined by TD.”

The outlet documented that 1 financial institution account gained C$1 million by means of GoFundMe and the relaxation was despatched to a 2nd account by a wide range of lender transfers. The spokesperson said TD is unsure of the place the GoFundMe payment originated.

Toronto Dominion financial institution signal in obvious sky. The lender is the next biggest and significant in the North American region. (Photograph by Roberto Machado Noa/LightRocket through Getty Illustrations or photos)

In an email to Reuters, Keith Wilson, an legal professional for the convoy, reported TD has been set “on see that their actions are incorrect and disappointing.”

GoFundMe confronted immense criticism before this month just after the organization resolved to pause the fundraising page for the convoy immediately after it surpassed $10 million.

Protesters of the Flexibility convoy get around the parliament hill as truckers keep on to protest in Ottawa, Canada on February 7, 2022. (Kadri Mohamed/Anadolu Company through Getty Images / Getty Illustrations or photos)

GET FOX Company ON THE GO BY CLICKING Here

The “Convoy” claimed that its initial protest of 1,600 vans swelled to 36,000 around the 1st 7 days, though the Washington Publish sites the selection closer to 8,000. The bring about has drawn worldwide focus and assist, with a U.S. trucker protest quite possibly beginning this weekend in Los Angeles about the Super Bowl, the Division of Homeland Safety announced.

FOX Business could not quickly get to Toronto-Dominion Bank or lawful illustration for the convoy.

February 13, 2022

REE Automotive to Participate in Leading Investor Conferences in Q1 2022

REE co-founder & CEO Daniel Barel will talk about how REE’s engineering, modular platforms, and enterprise product can speed up electrification for fleets throughout fireplace chats, 1-on-1 and compact group meetings

TEL AVIV, Israel, Feb. 11, 2022 (Globe NEWSWIRE) — REE Automotive Ltd. (NASDAQ: “REE”), an automotive technological know-how leader and service provider of electric powered motor vehicle platforms, these days declared that it will participate in a sequence of trader conferences in the initially quarter of 2022. Daniel Barel, REE co-founder and chief executive officer and David Goldberg, REE main fiscal officer, will examine REE’s manufacturing progress on its latest fully-flat P7 platform for industrial fleets, go-to-market place method with major associates for platforms and full autos, and technique for producing a entire ecosystem from charging infrastructure to Facts-as-a-Service to accelerate fleet electrification ideas.

Baird Sustainability Meeting – digital
Tuesday, Feb. 22 – Wednesday, Feb. 23
Hearth chat: 12 p.m. ET – obtainable for Baird customers only.

For access and/or 1-on-1 conference, please get hold of your Baird banker.

Cowen and Co – Mobility Disruption Summit – digital
Thursday, March 3
Fireside chat: 9:50 a.m. ET.

Berenberg Industrial Tech Conference – digital
Thursday, March 3

Roth Cash Companions – 34th Annual Roth Convention – The Ritz-Carlton, Laguna Niguel – Dana Place, California

Monday, March 14 – Tuesday, March 15

DA Davidson – EV & Electricity Transition Convention – digital
Tuesday, March 22

For current facts with regards to fireplace chat situations and webcast back links be sure to go to: https://traders.ree.vehicle/news-functions/activities

Investors who want to take part in a digital or a stay (where applicable) meeting with REE’s management in the course of the conferences could refer to their banking contact or to Limor Gruber, REE VP of Trader Relations, at Limorg@ree.vehicle.

For the most up-to-date investor information and facts go to: https://buyers.ree.auto

About REE Automotive

REE (Nasdaq: REE) is an automotive engineering chief whose mission is to empower organizations to create any size or form of electrical or autonomous automobile – from Class 1 by way of Course 6 – for any software and any focus on current market. REE aims to provide as the underpinning on prime of which EVs and AVs will be created and envisions a foreseeable future where by EVs and AVs will be ‘Powered by REE’.

REE’s revolutionary engineering – the REEcorner™ – packs significant car or truck elements (steering, braking, suspension, powertrain and command) into a solitary compact module positioned involving the chassis and the wheel, enabling REE to construct the industry’s flattest EV platforms with additional place for travellers, cargo and batteries. REE makes use of x-by-wire technological innovation to management each individual of the corners of the automobiles with comprehensive drive-by-wire, brake-by-wire and steer-by-wire.

REE’s EV platforms pay for finish flexibility of style and design, enabling automobile-makers, OEMs, shipping & logistic fleets, Mobility-as-a-Company vendors and new mobility gamers to style mission-specific EVs and AVs centered on their precise organization specifications and drastically reduce their time-to-current market, lower TCO and meet zero-carbon rules.

Headquartered in Herzliya, Israel, REE has an Engineering Centre in the Uk, as well as subsidiaries globally which includes Japan and Germany, and ideas to open up its U.S. headquarters and to start with Integration Centre in Austin, Texas. REE’s special CapEx-mild producing design leverages Tier-1 partners’ existing manufacturing traces the company’s in depth spouse ecosystem encompasses top names which includes Hino Motors (truck arm of Toyota), Magna Intercontinental, JB Poindexter, Navya and American Axle & Production to supply a entire turnkey solution.

REE’s patented technology, collectively with its one of a kind price proposition, position it to break new ground in e-Mobility. For additional info visit https://www.ree.vehicle.

Trader Relations
Limor Gruber
VP Trader Relations | REE Automotive
+972-50-5239233
investors@ree.automobile

Media
Caroline Hutcheson
Head of World Communications | REE Automotive
+1-252-314-2028
media@ree.automobile

Warning About Forward-Searching Statements
This interaction consists of forward-hunting statements in the that means of the Personal Securities Litigation Reform Act of 1995. All statements, other than statements of historical specifics, may well be ahead-on the lookout statements. Words such as “may,” “will,” “should,” “likely,” “anticipates,” “expects,” “intends,” “plan,” “projects,” “believes,” “views,” “estimates,” “future,” “allow”, “aims,” “strives,” “endeavors” and related expressions are employed to establish these ahead-seeking statements. These statements incorporate, between other items, the Company’s statements about the Company’s strategic and business enterprise options, interactions or outlook, the impact of developments on and desire in its company, mental house or products and its upcoming benefits. These ahead-on the lookout statements are primarily based on REE’s expectations and beliefs relating to upcoming situations and involve threats and uncertainties that may possibly trigger actual success to vary materially from present-day anticipations. These components are complicated to predict accurately and might be outside of REE’s regulate. Ahead-searching statements in this conversation or elsewhere discuss only as of the date built and REE undertakes no obligation to update its ahead-searching statements, no matter whether as a final result of new details, long term developments or otherwise, need to circumstances alter, other than as usually demanded by securities and other relevant guidelines. In light-weight of these hazards and uncertainties, buyers ought to hold in head that success, gatherings or developments talked about in any ahead-hunting assertion built in this communication may possibly not occur. Uncertainties and hazard aspects that could have an impact on REE’s future functionality and lead to success to differ from the ahead-searching statements in this release incorporate, but are not minimal to: REE’s ability to commercialize its strategic approach REE’s skill to preserve and progress associations with current Tier 1 suppliers and strategic companions advancement of REE’s sophisticated prototypes into marketable solutions REE’s skill to grow and scale manufacturing capability by relationships with Tier 1 suppliers REE’s estimates of device gross sales, expenses and profitability and underlying assumptions REE’s reliance on its Uk Engineering Centre of Excellence for the design, validation, verification, testing and homologation of its products REE’s constrained running record dangers affiliated with strategies for REE’s initial business generation REE’s dependence on prospective suppliers, some of which will be solitary or confined source development of the market place for professional EVs powerful competitors in the e-mobility house, together with with opponents who have significantly far more means pitfalls linked to the fact that the Firm is incorporated in Israel and ruled by Israeli regulation REE’s capability to make continued investments in its platform the impression of the ongoing COVID-19 pandemic and any other all over the world wellness epidemics or outbreaks that may perhaps come up the need to draw in, teach and keep extremely-experienced technological workforce variations in laws and regulations that affect REE REE’s means to implement, shield and preserve mental assets legal rights REE’s potential to keep engineers and other hugely qualified staff to further more its plans and other challenges and uncertainties established forth in the sections entitled “Risk Factors” and “Cautionary Observe Relating to Ahead-Looking Statements” in REE’s last prospectus relating to its organization blend submitted with the U.S. Securities and Trade Commission (the “SEC”) on July 1, 2021 and in subsequent filings with the SEC. Even though the listing of elements discussed previously mentioned and the list of things presented in the ultimate prospectus are regarded representative, no this sort of record ought to be regarded to be a total assertion of all possible threats and uncertainties. Unlisted things may existing considerable more hurdles to the realization of forward-hunting statements.

February 13, 2022

Novavax COVID-19 vaccine (Nuvaxovid): Data on side effects

New vaccines for COVID-19 are emerging. One such vaccine is Novavax. Early studies indicate that it may have similar efficacy to the Pfizer and Moderna vaccines but fewer side effects. Further trials and analyses of the initial results are underway to understand its effects better.

What side effects can the Novavax vaccine cause? Image credit: Mariano Vimos/Vizzor Image/Getty Images.

Medical News Today has contacted over 20 experts for comment on the potential side effects of the Novavax COVID-19 vaccine, Nuvaxovid. As of the time of publication, they have declined to comment until additional peer-reviewed data become available.

On January 31, 2022, Novavax submitted a request to the Food and Drug Administration (FDA) for emergency use authorization for its COVID-19 vaccine candidate.

Over 30 countries, including the United Kingdom, Australia, and Germany, have already approved this vaccine for emergency use.

Unlike mRNA vaccines, such as Pfizer and Moderna, the Novavax vaccine uses a longer-standing protein-based technology. The flu vaccine and the hepatitis B vaccine, which doctors have administered throughout the U.S. since 1986, use this technology.

The proteins inside the Novavax vaccine mimic COVID-19’s spike protein. They were created in moth cells and then assembled into nanoparticles – small particles made of a few hundred atoms. While they share COVID-19’s molecular structure, they do not replicate or cause COVID-19.

The vaccination involves injecting the nanoparticles into arm muscles alongside a compound extracted from the soapbark tree, which acts as an adjuvant to attract immune cells to the injection site.

A full course of the vaccine requires two doses taken 3 weeks apart.

The results from two large phase 3 trials on Novavax have been published.

One trial in the United States and Mexico included 29,949 participants ages 18 and over who had not previously contracted SARS-CoV-2. On a ratio of 2:1, they received two doses of either the Novavax vaccine or a placebo.

Overall, the researchers found that the Novavax vaccine was 92.6{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} effective against the Alpha and Beta variants of the virus. They also tracked side effects for 7 days after each dose.

While side effects occurred after the first dose, they were more common after the second dose. Common side effects included:

tenderness at the injection site for 73{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of participants
pain upon and after vaccination for 60{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of participants
fatigue for 50{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of the participants
muscle pain for 48{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of participants
headache for 44{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of participants
malaise for 39{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of participants

Less common side effects after the second dose included:

fever for 6{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of participants, including severe cases for 0.37{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}
nausea and vomiting for 11{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of participants, including severe cases for 0.23{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}
joint pain for 22{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of participants, including severe cases for 2.44{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}

A smaller trial including 15,187 participants in the UK found similar results.

Data so far suggest, that on the whole, the Novavax vaccine may have fewer side effects than both the Pfizer and Moderna vaccines.

After a second dose of the Pfizer vaccine:

66{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} reported pain
60{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} fatigue
52{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} headache
38{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} muscle pain
22{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} joint pain
16{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} fever
2{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} vomiting.

Meanwhile, after a second dose of the Moderna vaccine:

88{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} experienced pain
16{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} fever, including 1.4{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} severe cases
59{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} headache
66{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} fatigue
43{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} joint pain
19{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} vomiting.

Like the Novavax vaccine, side effects were more common after the second vaccine dose.

The World Health Organization (WHO) recommends Novavax for:

those living with conditions that increase the risk of severe COVID-19, such as cardiovascular disease, respiratory disease, and diabetes
people who have contracted COVID-19 in the past
people who are breastfeeding and those who are not

The WHO the following not to get the vaccine:

people with a history of anaphylaxis to any component inside the vaccine
people with symptomatic PCR-confirmed COVID-19 until they have recovered and finished self-isolation
people with a body temperature of over 38.5°C until they no longer have a fever
people under 18 years old, as research studying its safety and efficacy is still underway.

The WHO also highlights that data on having the vaccine during pregnancy is not yet available. However, as other protein-based vaccines have comparable efficacy in pregnant and non-pregnant people, they say that the Novavax vaccine may be the same.

Therefore, they recommend that pregnant people receive information about the risks of COVID-19 during pregnancy, the potential benefits of vaccination, and safety data limitations so that they can make their own decision. However, they recommend pregnant people get vaccinated in situations where the benefits outweigh the risks.

Any side effects from the vaccine were largely mild to moderate and transient. The phase 3 trial in the U.S. and Mexico, and the U.K did not raise any safety concerns.

According to Prof. Paul Heath, professor of paediatric infectious diseases and director of the Vaccine Institute, St George’s, University of London and St George’s Hospital, London, and chief investigator of the Novavax United Kingdom trial:

“The results are very reassuring and importantly show that this vaccine appears to be safe and effective in populations from a range of communities and demographic groups, and those with a range of underlying comorbidities, now (across both trials) with a total number of participants of more than 45,000.”

“Both the U.K. and the US. and Mexico trials used the same case definitions, and these consistent results, therefore, provide much confidence in the use of this vaccine for the global population. We now await the peer-reviewed publication. We also look forward to the results of the trial’s adolescent arm (12–17 years), which recently completed enrolment,” Prof Heath adds.

According to Dr. Peter English, a retired consultant in communicable disease control, former editor of Vaccines in Practice, and immediate past chair of the BMA Public Health Medicine Committee:

“[t]he vaccine is a much more traditional sort of vaccine than the mRNA and vector vaccines currently in use. The actual spike protein is injected, in the form of nanoparticles, instead of inserting the genetic material enabling our cells to create the spike protein.”

He adds that:

“It remains to be seen whether this will have consequences in terms of real-world effectiveness or safety; but the more different types of vaccine we have, the greater our ability will be to optimize effectiveness and safety in different groups.”

For live updates on the latest developments regarding the novel coronavirus and COVID-19, click here.