Link found between exercise, anxiety, and depression

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Many people may have benefitted from exercising outdoors during the coronavirus lockdowns in 2020 and 2021. Karwai Tang/Getty Images
  • A new study highlights the importance of being active and spending time outdoors, even during a pandemic.
  • The researchers found that people who exercised more during lockdowns experienced less anxiety and depression than those who did not exercise.
  • They also found that people who spent more time outdoors had lower levels of anxiety and depression than those who stayed inside.
  • Although stopping viral transmission remains key, such research could help governments reconsider some mitigation measures to lessen their negative effects on mental health.

The extent of COVID-19 lockdowns, curfews, and pandemic mitigation measures varied among countries throughout 2020 and 2021.

During the initial lockdown in March 2020, the United Kingdom, for example, allowed only one exercise session — for instance, going for a walk, run, or bike ride — a day. Turkey, meanwhile, did not make exceptions for outdoor exercise and only permitted people to leave their homes to shop for basic necessities. Many states in the United States took a different approach and put no caps on time spent outdoors.

The researchers behind a new study, which appears in the journal Preventive Medicine, aimed to look back on the effects such differences may have had on individuals in terms of mental health, especially during the first wave of the pandemic when the authorities imposed lockdowns.

They found that physical activity and time spent outdoors during the pandemic were associated with better mental health.

The healthcare company Kaiser Permanente (KP) led the study, which involved people from Hawaii, Colorado, Georgia, the mid-Atlantic states, and Southern and Northern California.

The researchers surveyed more than 20,000 people in April 2020 and at least three more times until July 2020. The participants, all of whom were enrolled in a KP plan, answered questions about their lifestyle, shared their electronic health records, and gave biospecimens.

Most of the respondents were retired and adhered to stay-at-home orders. White women aged 50 years and over constituted the majority.

After analyzing the data, the researchers saw that those who had exercised or spent more time outdoors had lower anxiety and depression scores.

They also found the following:

  • The participants reported fewer symptoms of anxiety and depression over time.
  • Females and younger people had higher anxiety and depression scores, while Asian and Black people had lower scores.
  • Those who did not report doing any physical activity during lockdown had the highest depression and anxiety scores.

However, the research found that the people who had increased the time they spent outdoors by the greatest amount also reported the highest anxiety scores. This was consistent in all demographic groups. The researchers could not explain this finding.

Lead author Deborah Rohm Young, Ph.D., the director of the Division of Behavioral Research for the Kaiser Permanente Southern California Department of Research & Evaluation, told Medical News Today she expected that more physical activity, as well as more time outdoors in nature, would be associated with lower depression and anxiety scores.

“The data is very clear that the mind and the brain are healthier when we spend more time […] in nature, but [also] just outdoors in general,” said Dr. David A. Merrill, adult and geriatric psychiatrist and director of the Pacific Neuroscience Institute’s Pacific Brain Health Center at Providence Saint John’s Health Center in Santa Monica, CA.

“There are studies that show that less time outdoors leads to brain atrophy, over time and with age,” he added.

Dr. Bert Mandelbaum, sports medicine specialist, orthopedic surgeon, and co-chair of medical affairs at Cedars-Sinai Kerlan-Jobe Institute in Los Angeles, told MNT that the study was comprehensive and measured a lot of different aspects before coming to a conclusion.

“At the end of the day, exercise activities and being outside are healthy behaviors that optimize people’s lives and decrease anxiety and depression,” he said.

However, Dr. Young pointed out some findings that surprised the team.

“I was surprised to observe that the depression/anxiety scores improved over time and also that both increasing and decreasing the amount of time spent outdoors was associated with higher depression and anxiety scores,” she said.

Dr. Merrill said that interpreting the findings was a bit complicated and involved a fair amount of conjecture.

One factor behind the discrepancies could be the lack of baseline levels of both physical activity and depression or anxiety scores from pre-pandemic times, he said.

Dr. Young said that not knowing how much time the respondents spent in nature prior to the pandemic was one of the limitations that could explain why more time outdoors was associated with a higher score of anxiety.

“It could be that people who spent less time outdoors did so because of adhering to the stay-at-home orders and felt deprived of their ability to be outdoors. Or that people who reported spending more time outdoors did so because they were experiencing poor mental well-being,” she said.

Dr. Mandelabum, however, said that this should not detract from the main finding of the study.

“I would focus more on the fact that [more people] improved by going outside, being in nature, and exercising in a high intensity way, which optimizes anxious and depressed states. [T]he real conclusion is the importance of physical activity and being outdoors,” he said.

Dr. Young noted that other findings were mostly consistent with earlier research.

“Many previous studies have documented that females tend to have higher anxiety and depression scores than males. There are also a number of studies suggesting that older adults have better mental well-being than younger adults,” she told MNT.

The research attributed the latter to adults having lived through more adversity and having more experience in dealing with stress.

According to Dr. Merrill, the new study highlights an important issue. He said that his colleagues have seen a disproportionate number of adolescent patients facing challenges with their mental health since the pandemic.

“The data is confirmation of the experience of mental health clinicians working in these populations — that younger adults, in particular, have struggled during the pandemic with disruption of their normal activities, [having been ordered to] stay at home, restricted from being in outdoor public spaces. This really comes out in the data that these restrictions had a significant negative effect on people’s well-being,” he told MNT.

“Living through that disappointment of not being able to do something as normal as going to the park can be a very big setback for a young person who otherwise may have been just having a nontraumatic, normal upbringing and a normal life.”

– Dr. David A. Merrill

Dr. Young expressed some surprise at the racial differences in depression and anxiety scores.

“Asian Americans tend to report lower depression and anxiety compared with white people. On the other hand, Black people tend to have higher scores than white people, so this was unexpected, and I don’t believe it’s reflective of the general population,” she said.

She said this finding could be down to only 2.3{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of the cohort being Black adults.

“As far as the difference in the levels of depression and anxiety in terms of race and ethnicity, the data speaks for itself. There’s no definite explanation,” said Dr. Merrill.

For Dr. Mandelbaum, the tools that the team used to measure anxiety and depression levels might explain the finding.

“The tools, these objective measures, and the data pointed out cultural, racial differences. Looking at those in a nonbinary way can be misleading. I think the tools are limited because if you have 10 people in a room, and there are 10 people from 10 different countries, even if you’re asked the question in the same language, you will see how different people interpret it. These tools are very hard [to optimize] across different cultures or languages,” he said.

Meanwhile, Dr. Merrill said that the finding could possibly reflect an often overlooked reality for racial minorities.

“If you’re already more under stress based on systemic exclusion, or marginalization, [the pandemic may not have had] such a big impact. For a population who is already under stress, if you add on more stress, there may be less of a change compared with a group that has enjoyed privilege or a stress-free life. In the U.S., that kind of seems to be the reality,” he explained.

The study shows that future pandemics will need better planning and more careful thinking around people’s mental health. This could affect decisions to close down outdoor spaces, for instance.

Dr. Young acknowledged that fighting a novel virus has been tricky for all countries.

“I’m sure we all would like to have consistent messaging throughout the pandemic, but as the knowledge changes, so do the recommendations,” she said.

However, the study’s findings reiterate that even during an active pandemic, physical activity or spending time outdoors could help people maintain their physical and mental health.

“Governments should promote physical activity and spending time in nature during pandemics. Public health messages have been consistent about getting vaccinated, staying masked-up, frequent hand washing, and maintaining physical distancing. It would be great if they can include positive messages like going for brisk walks.”

– Dr. Deborah R. Young

Dr. Merrill pointed out that although there were a lot of unknowns during the initial lockdown about what constituted risky behavior, many studies have shown that being outdoors is not as risky as experts once thought.

“I think keeping public health decisions away from political battles and focusing on the science, the data, including this new information that we’ve learned, can help minimize the negative impacts of the decisions that are made,” he said.

He continued:

“[M]aking good use of the data and sharing information about what’s been learned can help decrease anxiety and prevent the imposition of unnecessary restrictions that don’t actually increase our safety and health but do significant harm. Hopefully, we can consider this a lesson learned and do better [in the future].”

Long COVID may affect how women recover from exercise

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New research explores the link between long COVID and women’s ability to exercise. Artur Widak/NurPhoto via Getty Images
  • Long COVID or post-acute COVID syndrome is characterized by a multitude of symptoms that persist beyond the acute phase of 3–4 weeks after getting the SARS-CoV-2 virus.
  • Women hospitalized with COVID-19 are more likely to experience persistent deficits in cardiovascular and lung function than men in the months following discharge.
  • A new study found that even women with mild-to-moderate COVID-19 may experience slower declines in their resting heart rate after physical activity in the post-acute phase of the SARS-CoV-2 infection.
  • Such deficits in cardiovascular function during exercise are associated with reduced capacity for physical exercise and, potentially, activities of daily life.
  • Women presenting with specific long COVID symptoms, namely shortness of breath or joint or muscle aches, were also more limited in their ability to do a walking test than people who had had a SARS-CoV-2 infection but experienced no lingering symptoms.

Although the majority of individuals recover within the first 3–4 weeks after contracting COVID-19, a considerable number continue to experience lingering symptoms for weeks or months after this initial or acute phase of the disease.

These symptoms, which people refer to collectively as long COVID or post-acute COVID-19, include shortness of breath, loss of smell and taste, brain fog, headaches, and fatigue.

Studies have shown that more than half of the individuals hospitalized with COVID-19 during the initial phase of the SARS-CoV-2 infection show persistent impairments in cardiovascular and lung function several months after discharge. Furthermore, women hospitalized with severe COVID-19 are more likely than men to present with such persistent deficits in cardiovascular and lung function after discharge.

Individuals may present with persistent symptoms during the post-acute phase of COVID-19, regardless of the severity of symptoms during the acute phase of the illness. The effects of mild-to-moderate COVID-19 on lung and cardiovascular function and, subsequently, on daily physical functioning during the post-acute phase is not well-understood.

Researchers at Indiana University, Bloomington, recently examined how mild-to-moderate COVID-19 affected exercise capacity or tolerance during the post-acute phase in women. Exercise tolerance or capacity refers to the ability of an individual’s cardiovascular system to sustain physical activity.

The researchers used an exercise test called the 6-minute walk test to assess the persistent effects of SARS-CoV-2 infection on cardiovascular function in women during the post-acute phase of the infection.

They found that women with COVID-19 who had mild-to-moderate illness during the acute phase showed a slower decline in their heart rate after the 6-minute walk test than the participants in the control group. This difference was more pronounced in women actively experiencing long COVID symptoms.

However, encouragingly, they found no statistically significant differences in a range of other measures, including pre- and post-test oxygen saturations, pre- and post-test heart rate, ratings of perceived exertion, and ratings of perceived breathlessness.

The study’s lead author, Dr. Stephen Carter, a professor at Indiana University, told Medical News Today: “A puzzling feature of post-acute COVID-19 syndrome is the variable presentation of symptoms that appear to be independent of initial illness severity. The present work shows even those with mild-to-moderate initial symptoms can be affected with underlying cardiac-related irregularities with the potential to affect exercise tolerance and/or activities of daily living.”

“It’s also plausible that lingering symptoms, particularly muscle/joint pain and/or shortness of breath, may trigger a maladaptive pattern that accelerates systemic deconditioning. However, further research is needed.”

Dr. Ziyad Al-Aly, chief of research and education service at Veterans Affairs St. Louis Health Care System, also spoke with MNT. Dr. Al-Aly, who was not involved with the study, said, “Studies like this are important to help us understand why some people with long COVID experience profound exertional fatigue that may limit their ability to exercise and their ability to carry out activities of daily living.”

The study appears in the journal Experimental Physiology.

The study included 29 women who had experienced mild or moderate illness due to COVID-19. These women had received a positive SARS-CoV-2 diagnosis at least 4 weeks prior to the study, with the average time of diagnosis being 94 days before the study. The control group consisted of 16 women who had never tested positive for a SARS-CoV-2 infection.

Out of the 29 participants in the test group, 17 women reported experiencing at least one long COVID symptom at the time of the study. These long COVID symptoms included shortness of breath, fatigue, cough, muscle or joint pain, loss of smell or taste, and skin irritation.

The researchers administered pulmonary function tests to assess various aspects of lung function. They found that the women who had tested positive for SARS-CoV-2 exhibited reduced total lung capacity compared with those in the control group.

The researchers then evaluated changes in cardiovascular function during and after the 6-minute walk test. The test measures the distance that participants walk in 6 minutes at their normal pace, and researchers use it to assess exercise tolerance. The team adjusted the results for age, sex, and body mass index (BMI) to prevent these variables from influencing the test results.

There was no significant difference between the distances that the two groups covered during the test.

However, women with SARS-CoV-2 who experienced shortness of breath or joint or muscle pain had a lower adjusted distance value than those with SARS-CoV-2 who did not experience these long COVID symptoms.

The researchers assessed the blood pressure, heart rate, and blood oxygen or oxygen saturation levels before and immediately after the 6-minute walk test. They calculated the heart rate response during exercise by subtracting the heart rate at rest from the heart rate after the completion of the test.

The heart rate response during exercise is a measure of cardiovascular function, with a lower heart rate response being a predictor of reduced exercise capacity and cardiovascular disease-associated mortality.

The women in the SARS-CoV-2 group showed a lower heart rate response than those in the control group.

Moreover, the participants in the SARS-CoV-2 group who reported shortness of breath as a long COVID symptom at the time of the study had a lower heart rate response during the test than those in the SARS-CoV-2 group who did not have this symptom.

The researchers also measured heart rate recovery, which is another indicator of cardiovascular health and all-cause mortality.

Heart rate tends to drop immediately after strenuous exercise. Heart rate recovery measures the decrease in heart rate after the cessation of exercise. Specifically, heart rate recovery quantifies the decrease in heart rate at a predefined time interval — generally 1 minute — from the end of the physical activity.

In the current study, the researchers measured the participants’ heart rate at the end of each minute during the 5-minute recovery period after the 6-minute walk test.

The SARS-CoV-2 group participants showed a less significant decrease in heart rate at 1 minute after the completion of the test than those in the control group. This suggests that the decline in heart rate occurred more gradually in the women in the SARS-CoV-2 group. Such a delay in heart rate recovery is associated with reduced exercise capacity.

Furthermore, women in the SARS-CoV-2 group who exhibited specific long COVID symptoms at the time of the study had decreased heart rate recovery compared with the SARS-CoV-2 group participants without these symptoms.

Specifically, women in the SARS-CoV-2 group with symptoms such as fatigue, loss of taste or smell, joint and muscle aches, or shortness of breath had decreased heart rate recovery compared with women who had not had SARS-CoV-2.

“A lot of long COVID-19 patients are placed into rehabilitation programs that are designed for non-COVID-19 patients. These programs may not be suitable for long COVID patients. It is important to understand that people with long COVID need programs designed for them (pacing, etc.). Findings from this study and others should be taken into account when designing rehabilitation programs for people with long COVID,” said Dr. Al-Aly.

Dr. Carter noted: “SARS-CoV-2 participants and [people without the infection] were matched for age, BMI, smoking status, and history of cardiopulmonary disease. As such, we have better assurance that reported differences were attributed to SARS-CoV-2, as opposed to another comorbidity.”

“A strength of the work is that comparisons were performed among women — who appear to be susceptible to persistent SARS-CoV-2-related symptoms — during and following a 6-minute walk test.”

Dr. Carter acknowledged that the study had a few limitations. He said: “Indeed, the 6-minute walk test is a widely used clinical tool that offers insight into exercise capacity and walking autonomy. However, it should be noted we cannot disregard the possibility of undiagnosed pulmonary abnormalities and/or autonomic dysfunction that existed prior to a SARS-CoV-2 infection. Additionally, it is conceivable some controls may have had an asymptomatic SARS-CoV-2 infection and/or a previous false-negative diagnostic test for SARS-CoV-2.”

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