Combination therapy shows high success rate

Combination therapy shows high success rate

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A mix solution to prostate cancer procedure may possibly be the very best way ahead, according to new research. Picture credit history: MirageC/Getty Photographs.
  • Prostate cancer is a form of most cancers that can guide to dying.
  • The exact cure for prostate cancer will depend on the particular person and the cancer’s severity.
  • Researchers are even now working to make improvements to remedy possibilities for prostate most cancers.
  • A current research located that the blended use of a few distinctive therapies improved the survival charge amid males with prostate most cancers.

Cancer impacts persons all in excess of the world. Authorities are continually analyzing how various treatment plans can eradicate or gradual the unfold of cancer

Every form of most cancers is diverse, major to the progress of various treatment and detection procedures.

A recent study that appears in The Lancet observed that a certain put together remedy therapy might improve the survival fee for men with prostate most cancers.

Prostate most cancers is a person of the most frequent styles of cancer between men. As noted by the Centers for Disorder Handle and Prevention (CDC), in 2018, there have been over 210,000 new circumstances of prostate cancer, and practically 31,500 of those with prostate cancer died of it.

As pointed out by the American Cancer Society, a couple various procedures can support detect prostate most cancers. 1 is to do a prostate-specific antigen (PSA) blood take a look at.

If the PSA stage is better than a particular reference place, it can indicate prostate most cancers. Nonetheless, there are other explanations for the PSA stage to be high, so this is not a definitive diagnostic instrument.

Medical practitioners can also do a digital rectal test to experience the prostate and be aware abnormal lumps. To confirm the findings of an elevated PSA or an abnormal digital rectal test, health professionals will get a biopsy of the prostate. If this confirms the presence of prostate most cancers, treatment method can commence.

Therapy for prostate cancer may perhaps include one or various possibilities, these kinds of as surgical treatment, radiation, cryotherapy, hormone remedy, immunotherapy, and chemotherapy. Researchers are however operating to strengthen the treatment method solutions and survival amount for folks with prostate cancer.

The analyze in The Lancet was a randomized managed trial. Scientists divided adult men with prostate most cancers into three unique procedure groups.

The research integrated individuals that experienced formerly had to have their prostate taken off and had a specified PSA amount after prostate removal. A full of 1,792 individuals enrolled in the examine.

Scientists sought to learn if working with a unique, combined treatment method strategy increased survival rates and lessened extreme cancer progression.

They utilised the label “freedom from progression.” The a few treatment groups integrated the a few unique therapy methods:

  • team 1 gained a kind of radiation referred to as salvage prostate bed radiotherapy (PBRT), which exclusively targets the prostate spot following the removal of the prostate
  • team 2 been given the similar radiation as group 1 (PBRT) and also been given quick-term androgen deprivation treatment (ADT), which operates to suppress certain hormones to lessen the gasoline of cancerous prostate cells
  • group 3 obtained the same treatments as team 2, incorporating 1 extra ingredient: This team acquired PBRT, ADT, and pelvic lymph node radiotherapy (PLNRT), a variety of radiation that explicitly targets the lymph nodes in the pelvic place, which is the place prostate most cancers can distribute.

The review uncovered that freedom from progression following 5 many years was best for individuals in team 3. In team 1, pretty much 71{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of the team experienced independence from development. In team 3, the share was 87.4{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}.

These outcomes show that incorporating quick-time period androgen deprivation therapy and pelvic lymph node radiotherapy to salvage prostate mattress radiotherapy can help to make improvements to survival rates amid individuals with prostate most cancers.

Study author Dr. Alan Pollack observed the pursuing highlights to Health care News Right now:

“This is the first randomized analyze to display the incremental benefit of adding pelvic lymph node treatment to androgen deprivation remedy and common prostate mattress treatment method. This is a three-arm analyze developed to examination the intensification of treatment method from conventional of care prostate mattress RT (PBRT), PBRT in addition brief term androgen deprivation remedy (STADT), and PBRT furthermore STADT as well as pelvic lymph node cure (PLNRT). The major endpoint was 5-year flexibility from progression [and the study] confirmed that all round there have been incremental gains with the addition of ADT and then even further gains with PLNRT.”

The analyze authors do observe that working with this merged cure method is not devoid of hazards. They place out that it could increase the risk for specific bone marrow difficulties. They also observe that a extended follow-up time would be required to confirm the full usefulness of the cure.

Dr. Kelvin Moses, director of the Complete Prostate Cancer Clinic at Vanderbilt University Health-related Heart, who was not associated in this study, agreed that a lot more comply with-up study is desired, but reported that the outcomes so significantly are promising.

He discussed for MNT that “[t]his research reinforces the great importance of handle of the pelvic lymph nodes either at the time of operation, or in the placing of put up-prostatectomy recurrence.”

He extra that “[i]t remains to be noticed if the progression profit translates to a reduction in metastasis or loss of life from prostate cancer, but these final results are promising and can transform the paradigm for procedure of biochemical recurrence.”

The examine authors more observe that, as imaging of the prostate improves, it will impact how this treatment technique is used. But the exploration provides all round encouraging final results that survival fees can increase for all those with prostate most cancers with the correct type of treatment method.

Dr. Hayley Whitaker, a most cancers expert at the University Faculty of London, who was not included in this analyze, was enthusiastic with regards to its final results:

“There are quite a few strategies to treat patients with prostate cancer, but the buy that distinct remedies are utilised or combining unique solutions provides large probable to extend [the] life of guys by lots of decades.”

In accordance to her, “[t]his is groundbreaking analysis that has the potential to make a true affect on adult men remaining handled for prostate most cancers by building significant innovations in combining surgical procedure, radiotherapy, and hormone therapies.”

Pennsylvania high school student injured in on-campus shooting; suspect at large

Pennsylvania high school student injured in on-campus shooting; suspect at large

A university student at Erie Higher University in Pennsylvania was hurt in a unusual on-campus shooting Tuesday, authorities reported, and a suspect was nonetheless at big.

The sufferer was hospitalized with non-lifetime-threatening wounds and experienced been stabilized, law enforcement explained at an afternoon information convention. Detectives believe that they have recognized the shooter, a juvenile young than 15 whose identify was withheld, and officers have been seeking to observe the man or woman down.

“We’ve identified a suspect and we have consulted with the district attorney’s place of work — and the Erie college district,” Erie Law enforcement Deputy Main Michael Nolan explained at the information convention.

Nolan said investigators were in contact with the household of the suspect, who remained at huge. The shooter and the victim know each individual other, and the attack was not random, Nolan stated.

Police did not release the juvenile’s title. Nolan claimed only, “We are not able to release any more facts at this time.”

Erie County District Attorney Elizabeth Hirz indicated at the information convention that the suspect is young than 15 and for that reason would be treated as a juvenile if prosecuted.

Police have been dispatched for stories of photographs fired in a hallway at Erie Significant College at about 9:22 a.m., Nolan stated. Detectives imagine the shooter employed a 9 mm firearm and that a number of rounds were fired, he reported.

Law enforcement and college officers stated gunfire erupted as college was in session. “There were other college students in the vicinity,” Nolan stated.

Erie faculties Superintendent Brian Polito claimed the campus has by no means experienced steel detectors but that college students who are late to course are issue to checks with a metal detector wand. Students can also be selected at random to be checked for weapons with a wand, Polito said.

The faculty is shut through the conclusion of the 7 days, and pupils will be off for spring break following 7 days.

Counselors will be accessible for pupils at a nearby arts heart, the district claimed.

“We are devastated and angered by this senseless tragedy,” Polito explained in a assertion. “We are hoping for the total and speedy restoration for the student involved.”

The district said in a assertion much more than two several hours following it declared the capturing that the making was secure and that there was no energetic threat.

In an before assertion on Fb, Erie’s Public Faculties urged folks to “Stay Absent FROM THE Space Until finally Additional Discover.”

News: Erie, PA School Shooting
Julieonna Roye, 15, hugs her mom, Sharteya Evans, outdoors Erie Large College on Tuesday following college students ended up dismissed.Greg Wohlford / United states Today Network

The district extra that it was operating to coordinate guardian pickups. Buses ended up also obtainable to get children property.

“Evacuation by orderly dismissal will commence as soon as the district is cleared to do so by the Erie Bureau of Law enforcement,” the college technique said afterwards.

Mayor Joe Schember said the taking pictures was “really saddening.”

“Colleges ought to be risk-free spots exactly where little ones discover and develop,” he wrote in a assertion. “I know this is difficult for moms and dads to hear. But remember: all students are now protected!”

The president of the Erie Education and learning Affiliation, Mary Theuerkauf, admonished the university district for not having place stability measures in put.

“For decades, we have demanded that the Metropolis of Erie School District Administration and Faculty Directors confront the multitude of security and stability threats our employees have brought right before them. Each individual time, we’re explained to, ‘it will choose time, we’re performing on it,'” she wrote in a assertion, according to Erie News Now.

“No paperwork is truly worth a human everyday living. We will not stand by one particular day additional till the security of our college students and team is correctly resolved,” she explained.

Dennis Romero contributed.

These US counties still have ‘high’ Covid-19 levels as their states lift mask mandates, CNN analysis shows

These US counties still have ‘high’ Covid-19 levels as their states lift mask mandates, CNN analysis shows

Florida’s Hillsborough County is one particular of them.

In that county on Wednesday, Gov. Ron DeSantis approached a group of pupils carrying masks who were being standing behind a podium at the University of South Florida, wherever the Republican governor was scheduled to hold a news conference. He instructed the college students, “You do not have to use these masks. I suggest, remember to choose them off.”

But in accordance to the CDC’s newest steerage, folks are suggested to nonetheless wear masks indoors in counties that have “superior” amounts of Covid-19, such as Hillsborough County.

The CDC stated Thursday that “far more than 90{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}” of US residents are now in a area with small or medium Covid-19 community ranges. A CNN analysis of the facts finds that 7{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of the US populace is in counties with “superior” Covid-19 group ranges, down from 28{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} previous week.

DeSantis called the students’ mask-donning “preposterous,” but they ended up following CDC suggestions. Dr. Georges Benjamin, government director of the American Public Wellbeing Association, said DeSantis was “bullying” the students for putting on masks.

“Gov. DeSantis has confirmed himself to be somebody who does not comply with excellent science advice, naturally for political factors,” Benjamin told CNN on Thursday. “I was horrified at what he did.”

On Twitter, DeSantis spokeswoman Christina Pushaw doubled down on the governor’s feedback: “I signify, an individual experienced to say it, just after 2 a long time of propaganda that terrified and manipulated youthful men and women. Breathe totally free, truly feel safe and sound and be satisfied.”

Throughout the United States, most of the counties that continue to have substantial Covid-19 degrees, dependent on the CDC’s current metrics, may be afflicted by many things, Benjamin reported: small Covid-19 vaccination fees, constrained entry to health and fitness assets or the continuing spread of the Omicron coronavirus variant.

“Some of these areas ended up spots wherever Omicron kind of hit later on. So like Maine. If you look at Maine proper now, you would think, ‘Maine is extremely vaccinated why is Maine getting hit so greatly? They continue to have an outbreak going on there,’ ” Benjamin explained. “Perfectly, it can be due to the fact they received hit by Omicron afterwards.”

In which Covid-19 is still ‘high’ but mask mandates are lifting

Some of the counties that nevertheless have “significant” degrees of Covid-19 are in states that either never ever experienced indoor mask mandates or lifted their mandates previously on in the pandemic.

New CDC Covid-19 metrics drop strong mask recommendations for most of the country
Last 7 days, California dropped its indoor mask mandate for unvaccinated persons. In that state, 11 counties have “large” degrees of Covid-19. Illinois also lifted its statewide indoor mask requirement and has six counties with “significant” concentrations of Covid-19.
Oregon and Washington prepare to lift their principles requiring masks in indoor community sites on March 11. There are four counties with “significant” levels of Covid-19 in Oregon and four counties with “high” amounts in the point out of Washington, in accordance to the CDC’s updated metrics.

Only 1 state and a single US territory — Hawaii and Puerto Rico — nevertheless have indoor mask mandates on the state or territorial level and have not introduced plans to raise individuals prerequisites.

Even in states the place indoor mask demands are lifted, counties can nonetheless require indoor mask-putting on on the nearby degree, Benjamin told CNN.

“The states are stating, ‘OK, we governors are no more time heading to manage it statewide. We’re now likely to lift a mandate from our point of view, and we are going to make it possible for you to customise this,’ ” he claimed.

With the updated county-level CDC metrics, “I feel the brilliance of what CDC did was, they were being able to pull the knowledge alongside one another at the neighborhood neighborhood degree — to allow neighborhood communities to make individuals decisions when to consider masks [off]. But it also presents them the capacity to re-mask, improve screening plan as they will need to, open and shut items,” Benjamin explained. “I would hope this not only puts it again in the fingers of regional elected officers but it also, I would hope, even a lot more powerfully, places it back in the fingers of neighborhood public health and fitness officials. That’s what I hope.”

As the CDC shifts masking guidance, Americans are split on path forward
The CDC’s “Covid-19 group amount” metrics are centered on 3 parts of info in a community: new Covid-19 hospitalizations, medical center capacity and new Covid-19 instances. The CDC’s internet site consists of a record of US counties and their current Covid-19 stages.

Beneath the CDC guidance, up to date last week, men and women in counties with very low or medium Covid-19 neighborhood stages no for a longer time have to have to wear masks indoors except they are immunocompromised or at “superior danger” for significant Covid-19 and if so, the CDC endorses to communicate to their wellbeing treatment company about sporting a mask.

In places with “superior” Covid-19 community levels, the CDC advises anyone to don a mask in public indoor options, like schools.

At all group concentrations, the CDC also endorses persons get vaccinated and boosted, and get tested if they have indicators.

The CDC’s new metrics are calculated at the county level to make it possible for for a “far more focused” being familiar with of the results of the coronavirus regionally and to inform own steps, these kinds of as mask carrying, as well as community policy decisions, Adriane Casalotti, chief of federal government and general public affairs at the National Association of County and Town Wellbeing Officials, wrote in an e mail to CNN on Thursday.

“Having said that, there are two difficulties for protecting masking specifications at a nearby plan stage. A single would be condition rules that prohibit this kind of action,” Casalotti wrote. “Yet another is less formal: the tension of taking further action. In particular as several in the community want to transfer further than the pandemic, it can be a challenge to proceed insurance policies like indoor masking necessities, even if it tends to make sense scientifically because of to community problems.”

Total, it can be tricky to keep track of regardless of whether there has been an overall shift in mask mandates currently being lifted in locations that continue to have “higher” Covid-19 degrees, Casalotti mentioned.

“This is more durable to observe as a lot of locations dropped — or ended up in the course of action of moving away from — formal masking specifications even right before the new, extra qualified metrics ended up launched,” she wrote.

“In some of all those locations, regional policy often shifted from indoor masking requirements to powerful recommendations for indoor masking or supporting enterprises to make individuals conclusions location by locale,” she additional. “In these areas, the burden is truly put on the unique to know the position of the virus in their local community, how to attain high-top quality masks, and when and wherever to use them to guard by themselves and their families.”

Inflation, already high, could drive prices up further after Russia’s attack on Ukraine means these prices are going even higher

Inflation, already high, could drive prices up further after Russia’s attack on Ukraine means these prices are going even higher

Economists are racing to evaluate the impression of the assault, which could spark the most important war in Europe due to the fact 1945. The conflict is unlikely to idea the world-wide economic system back into economic downturn, they say, but sector tumult, the threat of punishing sanctions and potential supply disruptions are previously pushing up the wholesale price tag of electricity and some agricultural merchandise. Shoppers will pay out more for gasoline and food stuff as a result.

“Inflation is probably to peak at greater degrees that we ended up envisaging just a couple times ago,” stated Ben Could, director of international macro exploration at Oxford Economics.

Here’s what could get far more expensive about the planet as a end result.

World oil costs jumped higher than $105 for every barrel on Thursday, hitting their greatest stage given that 2014. In the United States, oil costs approached $100 for each barrel.

That will make it much more costly for motorists to fill up their tanks. In the United States, the common cost of a gallon of gas rose to $3.54, up from $3.33 just one thirty day period ago and $2.66 this time very last yr.

The Biden administration is checking out techniques to blunt the rise in fuel rates, although it is really not obvious how a great deal can be completed presented high demand from customers and limited provide.

The selling price of purely natural gasoline, which is utilised to warmth homes and energy field, is also spiking. The benchmark cost in Europe soared 29{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} to €114.65 ($127.80) for each megawatt hour on Thursday, according to knowledge from Impartial Commodity Intelligence Providers.

That is beneath the all-time substantial reached before Xmas, but will nonetheless strike pocketbooks if prices continue to be elevated. Bank of The us beforehand estimated that European households would spend €650 ($724) additional for energy this yr, bringing ordinary shelling out to €1,850 ($2,061).

Bigger electrical power fees will raise expenses for businesses, much too. Jet fuel will get pricier for airways, likely triggering better air fares, while companies that use a ton of energy, like steelmakers, will be squeezed. That could ripple across the financial state.

Food

International food stuff price ranges were being previously in close proximity to a 10-12 months high. Now, the Russia-Ukraine conflict could make matters even worse.

Russia is the world’s major exporter of wheat, while Ukraine is a sizeable exporter of equally wheat and corn. They also export vegetable oils.

Wheat rates jumped to their greatest amount due to the fact 2012 on Thursday. The cost of corn leaped, way too. Soybeans, which usually trade in line with corn, also pushed larger.

Egypt and Turkey are top rated prospective buyers of Russian wheat. But they will never be the only kinds affected if shipments are delayed or sanctions disrupt exports.

“No matter of particularly where foodstuffs go, evidently if you can find a shortage normally in the earth, then the price is likely to be driven up,” Might claimed.

Ukraine still wanted to export 15 million metric tons of corn and between 5 million and 6 million metric tons of wheat this time, in accordance to Rabobank commodities analyst Michael Magdovitz.

Now customers like China are turning to Europe and the United States to fill the gap. If preventing drags on, constrained supplies there could turn into even extra constrained.

“If you have a protracted conflict, then you will need to find a significantly better total,” Magdovitz explained.

Helima Croft, head of worldwide commodity technique at RBC Money Marketplaces, stated the possibility of higher food items cost inflation “appears acute” mainly because Russia and Ukraine alongside one another account for a 25{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of world wide wheat exports, while Ukraine on your own accounts for 13{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of corn exports.

And you can find another possible blow to farmers: Russia is the major producer of ammonium nitrate, a key element in fertilizer, RBC added.

US Agriculture Secretary Tom Vilsack mentioned Thursday that European consumers could be a lot more exposed to a leap in foodstuff rates than People in america.

Metals

The selling price of metals utilized in a extensive array of purchaser merchandise is soaring as buyers dig into the ramifications of the invasion and weigh whether sanctions could impact provides.

“Russia is a big producer of metals such as aluminum and nickel and is also a sizeable copper producer,” stated analysts at S&P Worldwide Platts. “Industry sources believe that the near-certainty that stricter sanctions will be launched on trade with Russia could additional squeeze supplies in worldwide markets that are by now limited.”

Aluminum prices in London shot up to a record high on Thursday.

Russia’s Rusal, which has been sanctioned by the United States previously, is a single of the world’s most significant aluminum producers. If refreshing penalties are imposed, it could cause costs to skyrocket.

Costs ended up by now elevated because smelters in Europe have experienced to slice their output thanks to mounting energy prices. Even if Rusal is just not sanctioned, the hottest spike in electrical power prices could exacerbate the circumstance.

Metals these kinds of as aluminum are made use of in hundreds of products close to the planet, from cans for food items and beverages to autos and electronics.

Honda exec: High auto prices may drop, but not dramatically

Honda expects its factories to make more motor vehicles this year irrespective of a laptop chip shortage and provide chain troubles

DETROIT — Honda expects its factories to make more automobiles this 12 months regardless of a laptop or computer chip scarcity and source chain problems. But since it really is starting up the year with so several cars at dealers, the corporation expects U.S. revenue to slide underneath final year’s figures.

The company expects U.S. new motor vehicle costs to relieve a bit from the history of a lot more than $46,000 in December as automakers raise production, but Govt Vice President of Countrywide Operations Dave Gardner explained prices will not fall to wherever they had been ahead of the pandemic.

A shortage of new autos brought on by the world chip lack has forced Honda and other automakers to reduce manufacturing unit production at a time when demand is potent. That has crimped the provide of new vehicles, in some cases driving price ranges greater than the window sticker.

Honda, with its Acura luxurious brand name, expects to provide somewhere all around 1.4 million automobiles in the U.S. this 12 months, which would be brief of previous year’s 1.47 million. Last 12 months, the automaker began with 300,000 motor vehicles in its U.S. stock. These days it has only about 20,000, Gardner stated.

“I assume we are expecting that we’re going to be able to construct much more than we had been final 12 months, but the pipeline has been emptied to this kind of a diploma,” he instructed reporters Wednesday.

Edmunds Govt Analyst Jessica Caldwell states Honda’s scenario is standard of the rest of the U.S. market. She expects output boosts, but claims automakers have 75{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} much less vehicles on dealer a lot than in a usual 12 months. And numerous of those people presently have been marketed.

As a final result, folks at this time are having to pay an normal of $700 in excess of the sticker value for an average of $46,426. “I think that overage that we’re seeing is in all probability likely to appear down,” she explained.

Gardner stated Honda carries on to see shortages of chips, and that ports are continue to clogged, slowing the move of parts to the level that Honda has at instances had to pay out additional for air freight shipments. The omicron variant of the novel coronavirus also is starting off to hit factory personnel, impacting manufacturing, he claimed.

Honda also declared Wednesday that it will roll out an all-new HR-V subcompact SUV this 12 months, adopted by an all-new CR-V compact SUV, and a new Pilot greater SUV.

Live: Police hold briefing after teen shot and killed following basketball game at Menchville High in Newport News

Newport News Police Chief Steve Drew is addressing the media and sharing updates in the case. Watch the news conference live in the player above.


NEWPORT NEWS, Va. (WAVY) — A teenage boy was shot and killed Tuesday night after a basketball game at Menchville High School.

This is the city’s 27th homicide of the year.

Newport News Police were called to the 200 block of Menchville Road in Newport News around 8:40 p.m. Tuesday night. In a news release, police said there was “some type of altercation” outside in the school parking lot after the basketball game.

Shots were fired, and a teenage boy was struck.

Police officers gave first aid and CPR to the boy, but he died at the scene.

The circumstances of the shooting are still under investigation. Police have not released any suspect information, but the police chief told 10 On Your Side they were looking into several leads.

Orlando Vincent was at the game in which the Menchville varsity basketball team fell to crosstown rival Woodside.

Vincent said when he and his family were walking out he heard the “pop” sound of a gun, but didn’t see anyone screaming or running.

“It was moments later we saw the large police response,” Vincent said. “It’s sad you can’t even go to a basketball game.”

Many people remained at the scene late Tuesday night, hugging each other, visibly upset.

Woodside High School and Menchville High School will be closed Wednesday. The other schools in Newport News have a regularly scheduled half day dismissal for students Wednesday.

On Wednesday, while schools are closed, there will be a support hotline that students can call from 8 a.m. to 7 p.m. for student support at 757-283-7868. After that, they will re-evaluate the plan for Thursday.

Around the same time as the shooting outside Menchville High School, 10 On Your Side started receiving reports from viewers about shots fired near Bethel High School in Hampton. Wednesday morning, Sgt. R.C. Williams confirmed there was evidence of shots fired, but said there is no indication the shots were made towards the school. There were no reports of injury or property damage. A basketball game was also underway at Bethel High School. Sgt. Williams said additional officers responded to assist with the dismissal of the game.

Newport News Police Chief Steve Drew is scheduled to address the media and share updates at 1:15 p.m. Wednesday.

Those with information can submit an anonymous tip by calling 1-888-LOCK-U-UP, downloading the P3 tips app to a mobile device, or visiting www.P3tips.com and submitting a tip.

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