NFL games today: Expert picks, predictions for NFL playoffs, divisional round schedule 2022

This week will decide who makes up our NFL “Final Four.” The divisional round of the playoffs has the potential to be the most entertaining round of the postseason, as we have a rematch of last year’s AFC Championship game and another chance for Aaron Rodgers to get his first playoff win against the San Francisco 49ers. Plus, Derrick Henry is returning for the Tennessee Titans against the Cincinnati Bengals, and Tom Brady and Matthew Stafford face off for the second time this year. If you’re looking for advice on what lines to play this weekend, you’ve come to the right spot.  

Every week, we collect all of the best picks and gambling content from CBSSports.com and SportsLine in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff and more.

All NFL odds via Caesars Sportsbook.

Which picks can you make with confidence in the divisional round? And which Super Bowl contender goes down hard? Visit SportsLine, as their incredible model simulates every NFL game 10,000 times and is up over $7,500 for $100 players on top-rated NFL picks since its inception six-plus years ago.

Cincinnati Bengals at Tennessee Titans

Time: Saturday, 4:30 p.m. ET (CBS), stream on Paramount+ (click here)
Open: Titans -3, O/U 47
Current: Titans -3.5, O/U 47.5

“If this game turns into a shootout, you have to like Cincinnati’s chances, especially since they’re going up against a Titans defense that struggles to stop the pass. During the regular season, the Titans were one of just eight teams in the league that surrendered more than 245 pass yards per game. If the Bengals can take advantage of that, it might be tough for Tennessee to keep up in a shootout. 

“The Bengals have NEVER won a road playoff game in franchise history (0-7), but after watching them end their 31-year drought without a playoff win, it’s starting to feel like they’re going to be ending a lot droughts this year.” — CBS Sports’ Bengals expert John Breech is on Cincy this weekend to score an upset victory. To read his full explanation and all of his picks for this round of the postseason, click here. 

“The Bengals are a much more scary matchup for the Titans than the Las Vegas Raiders would have been. If you had to point out a weakness on the Titans, it has to be the secondary/pass defense. Tennessee finished the regular season with the eighth-worst pass defense in the NFL, and the Bengals have a legitimate “big three” at receiver with Ja’Marr Chase, Tee Higgins and Tyler Boyd, and a great quarterback in Joe Burrow tossing the rock. The Bengals have what it takes to pull off an upset, but the Titans are the No. 1 seed in the AFC for a reason.

“Nissan Stadium is going to be rocking on Saturday, and it’s mostly because Derrick Henry is expected to make his return to the field. It’s fair to question if he will look like the same dynamic playmaker after two-and-a-half months off, but Tennessee is going to run the ball no matter who’s taking it from Ryan Tannehill. This Bengals defensive line has some issues worth worrying about. Larry Ogunjobi was placed on injured reserve, Mike Daniels is dealing with a groin injury and Josh Tupou has a knee injury — although he’ll play. I’m taking the Titans. The 3.5-point line is a bit weird, but winning teams are covering in the playoffs.” — CBS Sports’ Jordan Dajani is taking the Titans to win and cover Saturday. To read his full column, click here.

Before you make any Titans vs. Bengals picks, you need to see which side SportsLine expert Larry Hartstein is on. A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. This season he has been on fire. Hartstein has gone an astounding 22-11-1 on his last 34 picks involving Tennessee, returning more than $1,000 to $100 bettors. You can see who Larry is taking in the Bengals-Titans matchup over at SportsLine, and you can also get his top player prop pick for the game, along with more picks from SportsLine’s top NFL experts, in this featured article.

Time: Saturday, 8:15 p.m. ET (Fox), stream on fuboTV (try for free)
Open: Packers -5, O/U 47.5
Current: Packers -5.5, O/U 47

“I love betting on the 49ers and Kyle Shanahan as underdogs. Since taking over in San Francisco, Shanahan’s 49ers teams have gone 25-17 ATS as underdogs, compared to 16-24-1 as favorites. Taking it a step further, as road dogs, the Niners are 17-10 ATS. As road dogs outside the division, they’re 11-6. Aren’t these wonderful trends?

“Also, while they went 3-0 ATS last week, large favorites don’t tend to do well in the NFL playoffs. Including last week, they’re 11-13 ATS since the 2017 season, and my dumb brain tells me that we’re bound to see some regression this week after those blowouts last week. Maybe it’s wishful thinking, but my numbers back it up as well. I have the Packers much closer to being field-goal favorites in this matchup than nearly touchdown favorites.” — CBS Sports’ Tom Fornelli is taking San Fran to cover the spread. To read his best bets for this weekend, click here.

“I’m going to give the edge here to Kyle Shanahan over Matt LaFleur, as good as LaFleur has been, where Shanahan has taken care of business against him most of the time with the exception being this regular season. I think the 49ers are live to win the game, and I love them getting six. I don’t think it’s a great matchup for Green Bay, but it’s also a tough spot for San Francisco as well, going in there and having to play in that weather against this talented of a football team in the Packers.”

That’s Will Brinson’s take from the Pick Six Podcast, where he, R.J. White and Pete Prisco broke down all the games from a gambling perspective and gave out best bets. Give it a listen below and subscribe for great NFL content in your feed daily.

CBS Sports fantasy and gambling editor R.J. White has been on a tear with his picks involving the Packers. White has gone a remarkable 50-16-1 on his last 67 picks involving Green Bay, returning more than $3,100. In this game against San Francisco, White knows a crucial X-factor that has him backing one side of the spread. We can tell you he’s leaning Under the total, but to see his pick for this game you’ll have to go to SportsLine. You can also get his top player prop pick for the game, along with more picks from SportsLine’s top NFL experts, in this featured article.

Time: Sunday, 3 p.m. ET (NBC), stream on fuboTV (try for free)
Open: Buccaneers -3, O/U 48.5
Current: Buccaneers -2.5, O/U 48

“Tristan Wirfs being injured and his backup being shaken up really gives me concern. At some point, the injuries are going to catch up to the Buccaneers. Plus I had the Rams in the Super Bowl this year.” — CBS Sports NFL Insider Jonathan Jones is eyeing an upset in this matchup. To read his insider notebook and the rest of his divisional round picks, click here.

“Both of these teams turned in strong performances in the wild card round, each winning by multiple scores. While the Rams defeated the Bucs in their regular-season matchup, I do think the calculus changes with this game being played at Raymond James Stadium. At home, the Buccaneers averaged an NFL-best 409.8 yards per game and an average margin of victory of 16.1 points, which also topped the league. 

“The Rams were also a statistically strong team on the road this year but were under .500 away from SoFi Stadium against the spread. Against teams with a winning record, L.A. was also 2-5 ATS over their last seven games. I see Tom Brady being able to negate the Rams pass rush with quick throws from the pocket and pick his way down the field to build up enough of a winning margin that goes above this field goal spread.” — CBS Sports’ Tyler Sullivan is taking the Buccaneers to win and cover the spread this week. To read his column, click here.

Before you make any Rams vs. Buccaneers picks or any other NFL predictions, you need to see which side R.J. White is on. A CBS Sports fantasy and gambling editor, White ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. It’s no surprise, as White has cashed huge twice in the world’s most prestigious football handicapping competition, the Las Vegas SuperContest. In addition, White has gone an astounding 33-18-4 on his last 55 picks involving Tampa Bay, returning nearly $1,300. You can see who R.J. is taking in the Rams-Bucs matchup over at SportsLine, and you can also get his top player prop pick for the game, along with more picks from SportsLine’s top NFL experts, in this featured article.

Time: Sunday, 6:30 p.m. ET (CBS), stream on Paramount+ (click here)
Open: Chiefs -2.5, O/U 54.5
Current: Chiefs -2, O/U 54

“This is a rematch from a game earlier this season that the Bills won on the Chiefs’ home field. The Bills and Chiefs are both coming off impressive victories. Both Patrick Mahomes and Josh Allen lit up their opponents last week, but this is a big step up for both in terms of defenses. The Bills have the top-ranked defense in the league and built their pass rush in the offseason to beat Mahomes. The Chiefs defense isn’t as good, but it played much better over the course of the second half of the season. The Chiefs love to blitz, which will leave Allen free to run and make throws on the run. I think that will be the difference here. The Bills behind Allen will win a fun shootout for the ages.” — CBS Sports’ Pete Prisco has the Bills pulling off the upset! To read his breakdown of every game, click here.

“What an absolute banger of a game. My CBS bosses are running pure right now, catching 49ers/Cowboys and now this Josh Allen/Patrick Mahomes matchup. If you claim to KNOW how this game will go, you’re a liar. Or Biff Tannen. This is a heavyweight title fight on divisional round weekend. Mahomes gets the edge at QB, even if Allen has played better of late. Andy Reid is a fairly big edge over Sean McDermott, but let’s not forget Reid FIRED McD from the Eagles. These teams have met plenty of times previously, but running through Bill Belichick/New England, Reid/K.C./Mahomes and then maybe even Tom Brady is a gauntlet. The Bills could snuff out some curses with a win here. I don’t think anyone can guarantee a winner here, so I’ll take the points and the scrappy underdog with the better roster in a shootout.” — CBS Sports’ Will Brinson likes the Bills to advance to the AFC Championship game. To read his picks column, click here. 

Before you make Bills vs. Chiefs picks or any other NFL predictions, you need to see which side SportsLine expert Larry Hartstein is on. This season he has been on fire. Hartstein is 70-46-1 in his last 117 NFL sides, for a profit of more than $1800. In addition, Hartstein has gone an astounding 23-8 in his last 31 picks involving Kansas City, returning $1,400 to $100 bettors! Anyone who has followed him is way up. You can see who Larry is taking in the Bills-Chiefs matchup over at SportsLine, and you can also get his top player prop pick for the game, along with more picks from SportsLine’s top NFL experts, in this featured article.

Wisconsin vs Purdue, Predictions, Odds, TV Channel & Live Stream for Basketball Game Jan. 3

The Wisconsin Badgers are on the highway tonight from the #3 Purdue Boilermakers tonight. The Badgers have played just just one sport in the earlier two weeks thanks to covid scenarios in each the Badgers’ system and opposing teams’ systems.

The Badgers are coming off a slim victory about Illinois Condition at residence and now a great deal enjoy at Mackey Arena, a put they have struggled mightily, to enjoy the no. 3 workforce in the nation.

Wisconsin vs Purdue Odds: Unfold, Moneyline, Over/Beneath

The Badgers are regarded 13-point underdogs towards the Boilermakers tonight, according to the most recent odds from WynnBET. The odds that the Badgers address the 13 points are -115 (guess $100 to acquire $115). The odds that the Boilermakers include the distribute are established at -105 (guess $105 to earn $100).

The moneyline for this video game favors the Boilermakers bigtime to earn the recreation outright tonight, regardless of the score, with their odds at -800 (wager $800 to earn $100). The odds for the Badgers to get outright are set at +600 (bet $100 to acquire $600).

The over/under for this game is set at 140 points. The odds for the in excess of and the less than are established at -110 every single.

Wisconsin vs Purdue Prediction Tonight

I believe the Badgers are going to have their palms complete tonight. Not only will they have to enjoy just one of the top teams in the place that is loaded with expertise, but they will also have to participate in at Mackey Arena, a house of horrors for the Badgers. Wisconsin hasn’t defeated Purdue there because 2014 and is 5-42 all-time at the venue. Their very last acquire arrived versus North Carolina in the NCAA Event last 12 months, so not even from Purdue.

With this kind of a youthful team, I feel it is likely to be extremely hard for the Badgers to get a acquire on the highway, specially with how they have been taking part in recently.

I’m absolutely sure Johnny Davis will come all set to enjoy and hopefully, Davison can get very hot tonight, but the Badgers are however desperately wanting for that third scoring menace. Steven Crowl place up 21 details versus Illinois State, but will he be in a position to continue on that enjoy? It could be difficult specifically with Purdue trotting 7’4″ Zach Edey out there.

Unfortunately for the Badgers, I feel this could be a tough a person. I’d choose Purdue masking, the moneyline, and the more than tonight.

Wisconsin 64  – Purdue 81

Make your pick now on WynnBET!

What Channel is the Wisconsin Video game On?

You can capture the Badger sport tonight on the Large 10 Network (BTN) at 6:00 PM CT.

Wisconsin vs Purdue Reside Stream

For these that are seeking for streaming choices, FuboTV is 1 possibility to consider, primarily considering the fact that they are currently supplying a seven-day totally free trial for new end users. Today’s Wisconsin video game can be streamed are living on Fubo Tv set.

College football picks, schedule: Predictions against the spread, odds for top 25 games today in Week 13

Rivalry Week has arrived and with it some of the biggest college football games of the season will be going down Saturday. Bragging rights will not be the only thing on the line as division titles, conference championship game appearances and College Football Playoff invitations will all be up for grabs with 18 top 25 teams in action over the course of the day.

Ohio State and Michigan go head-to-head in The Game with the Big Ten East on the line. The Buckeyes and Wolverines each have a shot at a top spot in the College Football Playoff, but the victory in Saturday’s game must win out through the Big Ten title game. Oklahoma and Oklahoma State meet in Bedlam, each as one-loss Big 12 teams that would need a bit of help to get into the playoff. There’s also a chance the Sooners and Cowboys meet in a league title game rematch should the Sooners win.

Elsewhere, Georgia (at Georgia Tech) and Alabama (at Auburn) each have rivalry games to get through ahead of their matchup in the SEC title game.

While winning is all that matters for the standings, we care about whether these teams will cover their spreads. Be sure to stick with CBS Sports throughout the day for college football coverage from the opening kickoff onward. Let’s take a look at our expert picks for a loaded Saturday in Week 13.

Odds via Caesars Sportsbook | All times Eastern

No. 2 Ohio State at No. 5 Michigan

Noon| Fox, fuboTV (Try for free) — It’s so hard to go against the Buckeyes in this game. Even though I think this is the most complete Michigan team that Jim Harbaugh has fielded, after seeing the way the Buckeyes have flipped the switch the last two weeks, I don’t think the Wolverines are good enough to keep it within the number. They have an excellent defense and pass rush, but they’ve yet to face an offense even close to what Ohio State offers. If the Wolverines fall behind, they’ll have to abandon their strengths in an effort to keep up. So I’m laying the points with the Buckeyes while hoping the game is much closer. Prediction: Ohio State (-8) — Tom Fornelli

No. 3 Alabama at Auburn

3:30 p.m. | CBS, CBSSports.comCBS Sports App — I’ll take the points since a nearly three-touchdown spread screams “backdoor cover”. It’s impossible to trust the Crimson Tide offensive line, so I expect Auburn to force multiple empty possessions, which will allow T.J. Finley to keep his team in the game for at least three quarters. Finley will ultimately make a mistake or two that swings the game in the favor of the crimson and white … but not by three scores. Prediction: Auburn (+19.5) — Barrett Sallee

Penn State at No. 12 Michigan State

3:30 p.m. | ABC, fuboTV (Try for free) — There has to be some shell shock coming out of that stunning result at Ohio State last week, and while returning home should bring a more friendly environment for Michigan State, I think Penn State comes in with a little bit more juice. Taking the under is my favorite play because this should be a low-scoring game, but ultimately I’ll side with the Nittany Lions. Prediction: Penn State (-1.5) — Chip Patterson

No. 15 Texas A&M at LSU

7 p.m. | ESPN, fuboTV (Try for free) — Both of these teams have been disappointing relative to expectations, but LSU has played poor football against quality competition. The only ranked win of the season came against Florida, which proceeded to collapse. Texas A&M can limit LSU’s running game and make them one-dimensional enough to come away victorious. Prediction: Texas A&M (-6.5) — Shehan Jeyarajah

No. 10 Oklahoma at No. 7 Oklahoma State

7:30 p.m. | ABC, fuboTV (Try for free) — Oklahoma was a trendy pick to win the national championship entering the season — including by this author. Unfortunately, there’s only so much waiting we can muster before we acknowledge that the proverbial Mr. Godot is not coming. Oklahoma State has been consistently better and more dominant all season long, and its playing its best football with a chance to reach its first Big 12 Championship Game. The Cowboys won’t waste this moment. Prediction: Oklahoma State (-4) — Shehan Jeyarajah

Which college football picks can you make with confidence in Week 13, and which top College Football Playoff contender gets a huge scare? Visit SportsLine to see which teams will win and cover the spread — all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons — and find out.

College football picks, schedule: Predictions against the spread, odds for top 25 games today in Week 12

Championship races heading down the stretch, both at the conference and the College Football Playoff levels, ramp up on Saturday as the 2021 regular season gets closer to its conclusion. There’s no conference in which separation is potentially greater than the Big Ten, and two of the titans from the East Division in the conference with CFP aspirations are set to square off in a marquee top-10 showdown here in Week 12. 

The day begins with No. 7 Michigan State going on the road to Columbus to face a No. 4 Ohio State team that’s really seemed to find its offensive rhythm of late. The Buckeyes are significant favorites because of that offensive attack as well as the Spartans’ poor passing defense. Michigan State, however, enters with a massive chip on its shoulder. This is a team that feels disrespected by the CFP committee in being ranked behind No. 6 Michigan — a team it defeated this season. However, an upset win over the Buckeyes in Columbus would surely earn the Spartans the respect to which they feel entitled. 

Also in the spotlight Saturday is No. 2 Alabama, which can clinch the SEC West title and set up the most anticipated matchup of the 2021 season in the conference title game on Saturday, Dec. 4 with No. 1 Georgia with a win over no. 21 Arkansas. In the nightcap of the evening, No. 3 Oregon will look to boost its resume with a victory on the road against a tough No. 24 Utah squad. 

While winning is all that matters for the standings, we care about whether these teams will cover their spreads. Be sure to stick with CBS Sports throughout the day for college football coverage from the opening kickoff onward. Let’s take a look at our expert picks for the 12th full Saturday of the season.

Odds via Caesars Sportsbook | All times Eastern

No. 7 Michigan State at No. 4 Ohio State

12 p.m. | ABC, fuboTV (Try for free) — There are two factors at play for me with this pick. The first and most important one is that Michigan State is a good football team, so to get nearly three touchdowns with them against an Ohio State team that’s struggled to dominate opponents all season long is a hard deal to pass up. The other factor is the timing of the game. While this one is huge, Ohio State plays Michigan next week. The Buckeyes have been bad against the spread before the Michigan game, and they have failed to cover the spread a week before Michigan for seven straight seasons (they didn’t play last year). Prediction: Michigan State (+19) — Tom Fornelli

Iowa State at No. 13 Oklahoma

12 p.m. | Fox, fuboTV (Try for free) — Oklahoma’s poor performance against Baylor corresponded with its first matchup against a halfway decent defense. The bad news? The Cyclones might be even better on that side of the ball, and they boast a running back that will keep the chains moving. Oklahoma might find a way to pull away in a home game, but ISU can easily keep the game close once again. Prediction: Iowa State (+4) — Shehan Jeyarajah

No. 21 Arkansas at No. 2 Alabama

3:30 p.m. | CBS, CBSSports.comCBS Sports App — Arkansas’ offense will have enough success against Alabama to at least keep this one in doubt heading into the fourth quarter. Will KJ Jefferson and the rest of the offense get the job done? No. A late mistake or two will cost the Hogs in this one, but they’ll keep it within three touchdowns. Prediction: Arkansas (+20.5) — Barrett Sallee

No. 6 Michigan at Maryland

3:30 p.m. | Big Ten Network, fuboTV (Try for free) — Michigan’s defensive front will be the group that wins this game. Maryland has been able to move the ball between the 20s this season, but it has struggled when it gets into the red zone. That’s where the Wolverines will start to overwhelm a Terps offensive line that has failed to establish an edge against the better teams in the Big Ten. Prediction: Michigan (-14.5) — Chip Patterson

No. 3 Oregon at No. 24 Utah

7:30 p.m. | ABC, fuboTV (Try for free) — Utah’s only loss in the last two months came against an Oregon State team that is one of only two teams in the conference that averages more yards rushing per game than Utah. Now the Utes must face the other one in Oregon. The Ducks should win a close one. Prediction: Oregon (+3) — David Cobb

Which college football picks can you make with confidence in Week 12, and which College Football Playoff contender will go down hard? Visit SportsLine to see which teams will win and cover the spread — all from a proven computer model that has returned almost $3,500 in profit over the past five-plus seasons — and find out.

College football picks, schedule: Predictions against the spread, odds for top 25 games today in Week 5

Though this is only the fifth week of the 2021 college football season, plenty will be decided Saturday with multiple top-25 matchups on the slate and plenty of other ranked teams in action against tough opponents. Four straight weeks of unpredictable finishes and upsets have set the stage for what should be a wild remaining two thirds of the season.

There are four games between ranked opponents Saturday with with No. 8 Arkansas visiting No. 2 Georgia, No. 7 Cincinnati taking on No. 9 Notre Dame as a road favorite, Lane Kiffin’s No. 12 Ole Miss facing former boss Nick Saban’s No. 1 Alabama in the SEC on CBS Game of the Week, and undefeated Big 12 programs meeting when No. 21 Baylor travels to No. 19 Oklahoma State. In total, 23 ranked teams will be in action Saturday with the other two — No. 5 Iowa and No. 13 BYU — facing frequent opponents Friday night.

While winning is all that matters for the standings, we care about whether these teams will cover their spreads. Be sure to stick with CBS Sports throughout the day for college football coverage from the opening kickoff on Saturday to the final whistle. Let’s take a look at our expert picks for the fifth full Saturday of the season.

Odds via Caesars Sportsbook | All times Eastern

No. 8 Arkansas at No. 2 Georgia

Latest Odds:

Georgia Bulldogs
-16.5

Noon | ESPN, fuboTV (Try for free) — This massive spread seems like an overreaction to Georgia’s recent explosive offensive outings against overmatched foes. Don’t forget this team failed to score an offensive touchdown against Clemson in Week 1. Arkansas has proven its superiority against two quality opponents already this season, and those wins over Texas and Texas A&M will give it more than enough confidence to go Between the Hedges and give the Bulldogs a close fight. Prediction: Arkansas (+18.5) — David Cobb

No. 14 Michigan at Wisconsin

Latest Odds:

Wisconsin Badgers
-2

Noon | Fox, fuboTV (Try for free) — Given what I’ve written already, you’ve probably figured out which direction I’m heading. I know it’s been a while since Michigan has won in Madison, Wisconsin, and this will be the toughest test the Wolverines have faced so far (it’s their first road game), but I can’t trust Wisconsin. The Badgers offense has played too poorly, and this Michigan defense has been just as strong — if not better — as the Penn State and Notre Dame defenses that have suffocated it already this season. The Wisconsin defense will keep it close, but I do not see them winning this game unless the Badgers score on defense or special teams. Prediction: Michigan (+1) — Tom Fornelli

No. 7 Cincinnati at No. 9 Notre Dame

Latest Odds:

Cincinnati Bearcats
-2

2:30 p.m. | NBC, fuboTV (Try for free) — There’s just something startling about seeing Cincinnati favored at Notre Dame. The Bearcats are worthy favorites based on all the talent accumulated and the high standard set by coach Luke Fickell, but I’ll take the team that’s rolling right now. The Fighting Irish seem to come up with winning plays in close games every week, so if I think it’s going to be a close game, I’ll take the home dog that’s hot. Prediction: Notre Dame (+2) — Chip Patterson

No. 12 Ole Miss at No. 1 Alabama

Latest Odds:

Alabama Crimson Tide
-14.5

3:30 p.m. | CBS, CBSSports.comCBS Sports App — This 79.5 over/under in this game is the highest in an FBS game in four seasons, which suggests that both teams will have plenty of success moving up and down the field. That will play right into Ole Miss coach Lane Kiffin’s hands. Ole Miss will use tempo, quarterback Matt Corral will have a banner day through the air and on the ground, and this game will be in doubt deep into the fourth quarter. In the end, Crimson Tide QB Bryce Young will make a couple of plays late to win an instant classic in Tuscaloosa, Alabama. Bama will win but won’t cover. Prediction: Ole Miss (+14.5) — Barrett Sallee

Indiana at No. 4 Penn State

Latest Odds:

Penn State Nittany Lions
-12.5

7:30 p.m. | ABC, fuboTV (Try for free) — Last season, the Hoosiers took advantage of turnovers en route to their best season in a long time. Their points off turnovers margin of +41 ranked in a tie for 10th nationally with Ohio State, but keep in mind the Hoosiers played in only eight games. This season, Indiana ranks 95th nationally with a points off turnovers margin of -7. If Indiana can take care of the football, it can hang with the Nittany Lions. Unfortunately, nothing I’ve seen from the Hoosiers has me confident they’ll be able to do that. Indiana keeps it close into the early third quarter, but Penn State puts the game away after that. Prediction: Indiana (-10.5) — Tom Fornelli

No. 22 Auburn at LSU

Latest Odds:

LSU Tigers
-3

9 p.m. | ESPN, fuboTV (Try for free) — I’ll take LSU to win and cover due in large part to Auburn’s recent defensive struggles. The Tigers from The Plains are giving up 6.5 yards per play, and the secondary will have a tough time stopping LSU QB Max Johnson and star wide receiver Kayshon Boutte. Don’t get me wrong, this won’t be a blowout — far from it — but Johnson will make a play or two late to get out of there with a win. Prediction: LSU (-3.5) — Barrett Sallee

Which college football picks can you make with confidence in Week 5, and which top 25 favorite will go down hard? Visit SportsLine to see which teams will win and cover the spread — all from a proven computer model that has returned almost $3,300 in profit over the past five-plus seasons — and find out.