Today’s COVID-19 news: More big events canceled, hospitals make do worldwide | News



What the World Health Organization describes as a “tsunami of cases” as a result of the Omicron variant of the coronavirus could in fact be a turn for the better in the course of the pandemic, according to some scientists.







The Grammy Awards have been postponed because of the surging omicron COVID-19 variant.

The 64th edition of the music industry’s most prestigious — and sometimes most contentious — annual awards show had been scheduled to take place Jan. 31 at Los Angeles’ newly named Crypto.com Arena. (Until December, the venue had been known as Staples Center.)

And, just two weeks before it was to be held in Park City, Utah, the Sundance Film Festival is canceling its in-person festival and reverting to an entirely virtual edition due to the current coronavirus surge.

Festival organizers announced Wednesday that the festival will start as scheduled on Jan. 20 but will shift online. The festival had been planned as a hybrid, with screenings both in Park City and online. Last year’s Sundance was also held virtually because of the pandemic.



Grammys postpone ceremony, citing omicron variant risks



Sundance cancels in-person film festival due to virus surge



NFL looks at contingency sites for Super Bowl amid COVID-19

Internationally, Hong Kong authorities announced a two-week ban on flights from the United States and seven other countries and held 2,500 passengers on a cruise ship for coronavirus testing Wednesday as the city attempted to stem an emerging omicron outbreak.

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The two-week ban on passenger flights from Australia, Canada, France, India, Pakistan, the Philippines, Britain and the United States will take effect Sunday and continue until Jan. 21.



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France announced a staggering 332,252 daily virus cases Wednesday, smashing a string of recent records, as hospitals prepared drastic measures to brace for patient surges and the government strained to avoid a new lockdown.

With Europe’s highest-ever single-day confirmed infection count, France is facing an omicron-driven surge that is dominating the race for April’s presidential election and increasingly disrupting workplaces, schools and public life.



France allows some COVID-19-infected medics to keep working



Italy requires coronavirus vaccines for people 50 and older

Back home, hospitals across the U.S. are feeling the wrath of the omicron variant and getting thrown into disarray that is different from earlier COVID-19 surges.

This time, they are dealing with serious staff shortages because so many health care workers are getting sick with the fast-spreading variant. People are showing up at emergency rooms in large numbers in hopes of getting tested for COVID-19, putting more strain on the system. And a surprising share of patients — two-thirds in some places — are testing positive while in the hospital for other reasons.



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Chicago cancels classes as union refuses in-person teaching

At the same time, hospitals say the patients aren’t as sick as those who came in during the last surge. Intensive care units aren’t as full, and ventilators aren’t needed as much as they were before.

The pressures are nevertheless prompting hospitals to scale back non-emergency surgeries and close wards, while National Guard troops have been sent in in several states to help at medical centers and testing sites.

Today’s coronavirus news: Ontario reports another 1,053 cases, eight deaths for Saturday; Outgoing Chancellor Angela Merkel makes final appeal for Germans to get vaccinated

The latest coronavirus news from Canada and around the world Saturday. This file will be updated throughout the day. Web links to longer stories if available.

10:57 p.m.: More cases of the Omicron COVID-19 variant were confirmed in Ontario on Saturday as the province recorded more than 1,000 new virus cases for the second day running.

The latest infections involving the variant of concern emerged in Hamilton and Peel Region, according to news releases from local authorities.

Officials said a Hamilton local resident who returned from travelling to South Africa recently tested positive for Omicron, while a second potential case is under investigation with sequencing results expected in the coming days.

It also noted that Hamilton Public Health Services is conducting case and contact management and the two individuals and their case contacts continue to self-isolate.

Read the full story here.

10:18 p.m.: Five people in Sydney have contracted the omicron variant locally, New South Wales health authorities said.

The cases are linked to two schools and a climbing gym in Sydney’s western suburbs, which may also be the source of a confirmed omicron infection in the Australian Capital Territory, NSW Chief Health Officer Kerry Chant said Sunday. Urgent genome testing is under way for a number of other cases linked to the venues and should be available in coming days, she said in a video update.

New South Wales state has confirmed 15 omicron infections and more are likely, Chant said. The outbreak was seeded from infected travelers on a flight from Doha who had been in southern Africa.

Separately, Australia will begin vaccinating young children starting early next year once authorities receive final approvals in the coming weeks.

9:41 p.m.: Ten people aboard a Norwegian Cruise Line ship approaching New Orleans have tested positive for COVID-19, officials said Saturday night.

The Norwegian Breakaway had departed New Orleans on Nov. 28 and is due to return this weekend, the Louisiana Department of Health said in a news release. Over the past week, the ship made stops in Belize, Honduras and Mexico.

More than 3,200 people are on board the ship, officials said.

According to the statement, Norwegian “has been adhering to appropriate quarantine and isolation protocols as new cases and exposures have been identified aboard this vessel.”

Prior to disembarking in New Orleans, each person on board will be tested for the coronavirus. Anyone who tests positive will either go directly home or self-isolate in accommodations provided by the cruise line, officials said.

Officials did not release any information about the conditions of those who have contracted the virus.

Cruise ships were an early source of outbreaks last year at the start of the coronavirus pandemic as some ships were rejected at ports and passengers were forced into quarantine. Some passengers died of COVID-19 at sea while others fell so ill they had to be carried out of the vessels on stretchers.

The U.S. Centers for Disease Control and Prevention issued a no-sail order in March 2020, prompting a standstill that ended last June as cruise ships began to leave U.S. ports with new health and safety requirements. According to Norwegian’s website, the company requires all passengers and crew members to have been vaccinated against the virus at least two weeks prior to departure.

8:55 p.m.: About 15 people who attended an animé convention in New York in November with a Minnesota man who later was found to have the omicron variant have also tested positive for the coronavirus, the man has told health officials in his state. It is uncertain whether any of those cases involved the omicron variant.

The man said that his friends — a group of about 30 people — had come from all over the country for the event, which was held Nov. 19-21. About half of them also later tested positive for the virus, he told the officials.

The man, officials said, was fully vaccinated and had gotten a booster just weeks before the convention. He has recovered from mild symptoms that began shortly after the convention ended and has provided health officials with names and contact information of several in his group. Because the friends live in other states, their names were forwarded to those states’ health departments. Details of their cases are not known.

The Minnesota man’s case was among the first reports of omicron in the United States, and it presented a worrisome possibility for health officials: Might the animé convention, which drew tens of thousands of people to the Jacob K. Javits Convention Center for three days, have been a vector for spreading the new variant, which scientists fear may be able to spread more quickly than any other variant?

After learning that the man had attended a large convention in New York, Kathy Como-Sabetti, manager of the COVID epidemiology section for the Minnesota Department of Public Health, said, “I kind of went, ‘Wow, well, this changes our story.’ This changes the picture of what we’re dealing with.”

At the Animé NYC conference, focused around a popular animation style that originated in Japan, attendees were fairly compliant about wearing masks, the man told officials. But some rooms were very crowded, at capacity, with crowds standing shoulder to shoulder, he said.

Convention attendees were required to provide proof that they had received at least one vaccine shot, and they had to wear masks, according to the convention website. The rules allowed entry “immediately after” a first dose. People are seen as having full vaccination protection two weeks after a second dose of a two-dose vaccine.

7:37 p.m.: Australia’s Parliament House will be closed to the public for the foreseeable future after a political staffer for Greens leader Adam Bandt tested positive for the coronavirus.

The staffer is fully vaccinated and tested positive upon return to Melbourne after attending parliament last week, a spokesperson for Bandt said in a statement. Other staffers have been cleared while Bandt, who is vaccinated, is isolating until he receives a result, according to the statement.

Given the positive result, officials “have decided that Parliament House should close to the public until further notice,” the Department of Parliamentary Services said in a separate statement. Authorities said they are investigating possible close contacts, exposure locations in parliament as well as in the broader community.

The Australian Capital Territory, home to capital Canberra, recorded six cases on Sunday, a health department spokeswoman said by phone. Neighboring New South Wales state found 286 new virus cases, while Victoria state recorded 980 new infections, according to separate statements on Twitter.

6:06 p.m.: A rush of vaccine-seeking customers and staff shortages are squeezing drugstores around the U.S., leading to frazzled workers and temporary pharmacy closures.

Drugstores are normally busy this time of year with flu shots and other vaccines, but now pharmacists are doling out a growing number of COVID-19 shots and giving coronavirus tests.

The push for shots is expected to grow more intense as President Joe Biden urges vaccinated Americans to get booster shots to combat the emerging omicron variant. The White House said Thursday that more than two in three COVID-19 vaccinations are happening at local pharmacies.

And pharmacists worry another job might soon be added to their to-do list: If regulators approve antiviral pills from drugmakers Merck and Pfizer to treat COVID-19, pharmacists may be able to diagnose infections and then prescribe pills to customers.

“There’s crazy increased demand on pharmacies right now,” said Theresa Tolle, an independent pharmacist who has seen COVID-19 vaccine demand quadruple since the summer at her Sebastian, Florida, store.

5:46 p.m.: The U.K. will require all travelers to take a pre-flight COVID-19 test within 48 hours prior to their flight regardless of their vaccine status, a surprise government move that prompted a swift and angry reaction from the airline industry.

The measure, which takes effect on Dec. 7, will be temporary and be reviewed as the omicron outbreak develops, Health Secretary Sajid Javid said. More than 150 people across the U.K. have been identified with the new variant.

Travelers will be allowed to take either an instant test or a PCR test. After omicron was detected in the U.K. a week ago, the government added a required PCR test within two days of arrival, requiring travelers to self-isolate until they received a negative result.

The risk of a second lost winter has already tanked shares of airline stocks, with the Bloomberg EMEA Airline Index losing 18 per cent in November, its worst monthly performance in more than a year.

4:43 p.m.: As the number of confirmed cases of the omicron coronavirus variant rose to 160 in Britain, the government Saturday announced further tightening of travel restrictions to combat its spread. Beginning Tuesday, travelers will be required to take a coronavirus test within 48 hours of traveling to Britai…

As the number of confirmed cases of the omicron coronavirus variant rose to 160 in Britain, the government Saturday announced further tightening of travel restrictions to combat its spread.

Beginning Tuesday, travelers will be required to take a coronavirus test within 48 hours of traveling to Britain regardless of their vaccination status and restrictions will be placed on travelers from Nigeria, the country’s health secretary said in a statement. Nigeria announced Wednesday that it had detected the variant in three travelers who arrived from South Africa in November, according to Dr. Ifedayo Adetifa, director-general of the Nigeria Center for Disease Control.

The two additional measures being imposed by Britain are the latest to come after a week of heightened concern led to the introduction of a number of restrictions intended to slow the incursion of the omicron variant.

At the moment, travelers are required to self-isolate and take a coronavirus test on the second day after arriving. If that test is negative, they can end their isolation. If not, they are expected to remain in self-isolation until they do get a negative result.

4:22 p.m.: The major of Rio de Janeiro canceled plans for the city’s New Year’s Eve celebrations following advice from the state that they weren’t safe to go ahead as the first cases of the omicron variant were reported in Brazil.

“We respect science,” Mayor Eduardo Paes wrote on his Twitter account Saturday. “The City Council says it can go ahead. The State’s says no. So it can’t. We will thus cancel the official New Year’s Eve celebration in Rio.”

Paes said there was no way to organize the celebrations without a guarantee from all health authorities. The party “will be missed, but the important thing is that we continue vaccinating and saving lives,” he said.

Rio de Janeiro Gov. Claudio Castro said on his Twitter account that he’ll meet Paes next week to make a final decision on the issue.

Brazil has reported 22.1 million COVID-19 cases, with 10,627 confirmed in the last 24 hours, according to Health Ministry data. More than 20 capitals have canceled their New Year’s Eve events amid concerns regarding the omicron variant, Exame reports, citing official statements.

4:08 p.m.: One more case of the Omicron COVID-19 variant was confirmed in Ontario on Saturday as the province recorded more than 1,000 new virus cases for the second day running.

The latest infection involving the variant of concern emerged in Hamilton, according to a news release from the city. Officials said one local resident who returned from travelling to South Africa recently tested positive for Omicron, while a second potential case is under investigation with sequencing results expected in the coming days.

It also noted that Hamilton Public Health Services is conducting case and contact management and the two individuals and their case contacts continue to self-isolate.

“As we have since the beginning of the COVID-19 pandemic, Hamilton Public Health Services follows up directly with all individuals diagnosed with COVID-19 and their close contacts,” the release reads. “Hamilton Public Health Services is working with the Province of Ontario and Public Health Ontario to monitor COVID-19 variants of concern including Delta and Omicron and will take strong action if necessary.”

Canada’s first known cases of the Omicron variant emerged last week when two positive tests were confirmed in Ottawa.

3:36 p.m.: New York announced three more cases of the omicron variant of the coronavirus Saturday, bringing the number of state cases linked to the new variant to eight.

“The omicron variant is here, and as anticipated we are seeing the beginning of community spread,” state Health Commissioner Mary Bassett said in a news release.

The number of states finding the variant is growing as well, with authorities in New Jersey, Georgia, Pennsylvania and Maryland reporting their first confirmed cases Friday, and Missouri reporting its first presumed case.

The variant also has been detected in Nebraska, Minnesota, California, Hawaii, Colorado and Utah.

In New York, seven of the cases have been found in New York City, once a global epicenter of the pandemic, and the other in Suffolk County.

The arrival of omicron comes as hospitals statewide continue to strain under a surge in coronavirus cases, most traced to the delta variant, along with staffing shortages.

The number of people testing positive statewide each day for the virus has doubled in the last 30 days.

Gov. Kathy Hochul in recent days has authorized the Health Department to limit nonessential, non-urgent procedures at hospitals close to running out of beds and deployed National Guard teams to relieve healthcare workers at facilities dealing with staffing issues and surging caseloads.

Fifteen members of the National Guard arrived at Monroe Community Hospital in Rochester on Saturday, WROC reported. Lt. Gov. Brian Benjamin said Wednesday the state would send 13 National Guard teams to the western New York county, where County Executive Adam Bello has declared a state of emergency.

3:15 p.m.: Health officials in New Brunswick are reporting 77 new cases of COVID-19 on Saturday as the province prepared to enter the first phase of its so-called winter action plan.

The province will enter Level 1 of the plan as of Sunday, which is the least restrictive of the three tiers.

Among other things, masking will be required outdoors when physical distancing cannot be maintained.

Physical distancing will also be mandatory in indoor public spaces that do not require proof of vaccination, such as retail stores, malls, salons and spas.

A maximum of 20 people is permitted for informal indoor household gatherings, and 50 for informal outdoor gatherings.

And it is recommended that unvaccinated individuals who are eligible to be vaccinated should not attend household gatherings.

The province’s number of active COVID-19 cases stood at 722 as of Saturday, which included 51 people in hospital — 16 of them in intensive care.

Eighteen of the hospitalized patients were initially admitted for other reasons and contracted COVID-19 due to outbreaks at hospitals in Moncton, Saint John and Miramichi.

3:14 p.m.: Chile on Saturday reported its first case of the omicron variant of the coronavirus.

A foreign national residing in Chile returned from Ghana on Nov. 25 and tested positive in a PCR test at the Santiago airport, according to authorities.

The foreigner, who had two Pfizer vaccines, is in good health and in quarantine, while other passengers on the flight he was on were being monitored, health officials in Valparaíso said in a statement.

12:22 p.m.: A Hamilton resident who recently returned from travelling to South Africa has tested positive for the COVID-19 Omicron variant, the city of Hamilton said in a news release Saturday.

The resident is one of two people under investigation by the city’s Public Health Services.

Testing results for the second case are expected in the coming days.

The statement from the city said the two individuals and their case contacts are self-isolating.

11:47 a.m.: Quebec is reporting another jump in COVID-19 cases today with 1,512 infections and one further death attributed to the virus.

The Health Department says 225 people are hospitalized, a drop of five, including 60 people listed in intensive care, an increase of three patients.

The province hasn’t reported more than 1,500 daily infections since mid-April, and the seven-day average for new cases is 1,089.

More than half of the new cases were among people who were either unvaccinated or less than two weeks removed from receiving their first dose of vaccine.

Quebec has reported 453,380 COVID-19 cases and 11,586 deaths since the beginning of the pandemic.

Due to a technical error, the province was not able to provide an update on vaccinations today.

10:49 a.m.: Rio de Janeiro on Saturday canceled its New Year’s Eve party due to renewed COVID-19 fears.

Rio Mayor Eduardo Paes announced the decision on social media.

Paes had previously promised the biggest New Year’s Eve party ever, with multiple firework displays and artists performing on a dozen stages across the city. He said there is no decision about Carnival taking place in March.

The yearly celebration on Copacabana beach has in the past gathered more than one million locals and tourists.

Other Brazilian cities, including Sao Paulo and Salvador, have also canceled New Year’s Eve celebrations due to fears of the omicron variant,. So far, the Ministry of Health has confirmed five omnicron cases in Brazil.

9:51 a.m.: Ontario is reporting another 1,053 cases and eight deaths on Saturday.

Individuals who are not fully vaccinated represent 23.4 per cent of Ontario’s total population, amounting to 494 of Ontario’s 1,053 new reported cases, and 60 cases are in individuals with an unknown vaccination status.

The current seven-day average is 894 cases per day, which is up 22.7 per cent in a week, or a doubling pace of every 24 days.

Additionally, in the province 23,913,372 vaccine doses have been administered — 90.0 per cent of Ontarians aged 12+ have had one dose and 87.3 per cent have had two doses.

There are 284 people hospitalized with the virus, of which 220 are not fully vaccinated or have an unknown vaccination status and 64 are fully vaccinated.

In the ICU there are 160 people due to COVID-19 — 136 are not fully vaccinated or have an unknown vaccination status and 24 are fully vaccinated.

8:08 a.m.: Public Health Sudbury and Districts says it is pulling out all the stops to help curb the rapid spread of COVID-19 cases in local schools.

With more than 3,000 vaccination appointments booked in the Sudbury and Manitoulin districts for children aged five to 11 and hundreds of rapid antigen screening kits distributed to students this week, there is hope that cases will decrease ahead of the Christmas break.

Although it’s too early to tell if these “additional layers of protection” are doing the trick, a health promoter at Public Health said she is confident these measures will help protect the school community.

Joëlle Martel added the local response to these programs have been positive so far and the health unit has been on hand to answer any questions that parents/guardians might have.

“Right now, the goal is to keep kids in school,” said Martel, who works in Public Health’s school health, vaccine preventable diseases, and COVID prevention division.

“If we start seeing cases go down and the trend holds steady, then we can slowly start to remove some of those measures, but our goal remains to keep kids in school as much as possible.”

Saturday 8 a.m.: Outgoing Chancellor Angela Merkel on Saturday made what is likely her final appeal before leaving office next week for Germans to get vaccinated against COVID-19.

Merkel gave what is expected to be her last weekly video message two days after federal and state leaders decided on a series of measures meant to break a wave of coronavirus infections.

The measures include excluding unvaccinated people across the country from non-essential stores, restaurants and sports and cultural venues. In a longer-term move, Parliament will consider a general vaccine mandate.

At least 68.9{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of Germans are fully vaccinated against the coronavirus, short of the government’s aim of a minimum 75{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} vaccination rate. The number of unvaccinated residents has been blamed as a key factor in a surge of new virus cases in recent weeks.

Official figures suggest that the infection rate may now be stabilizing, but at too high a level.

Read Friday’s coronavirus news.

Today’s Business and Stock Market News: Live Updates

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Erin Griffith

Another subsequent Theranos test shows levels more in line with expectations. Note from the doctor says “clearly some form of lab error occurred.”

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Erin Griffith

The test results show a “very significant rise” in PSA levels. The doctor wrote a note on it that it should be rechecked and might be a “lab error.”

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Erin Griffith

Mr. Burnes had a patient who got a PSA test — detects prostate cancer — through Theranos. The doctor is testifying in a clear mask and I have to say it just conveys Bain vibes to me. Also hard to hear.

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That’s it for Tompkins. The U.S. has called Dr. Mark Burnes.

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Theranos test results told this woman she had HIV antibodies. Defense is trying to argue she didn’t understand the test results.

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Trefz pulls up an HIV testing algorithm to show the patient. She asks the patient to break down the arrows pointing to terms like HIV-1/2 antigen/antibody combination immunoassay. … “You don’t know the meaning of these particular steps, correct?”

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Tompkins is back on the stand being cross-examined by Holmes lawyer Katie Trefz. She says she attempted to get information about the testing from Theranos but was not provided any.

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🩸 U.S. v. Holmes continues. 🩸 Today we’ll hear from Erin Tompkins, a patient, as well as Roger Parloff, a journalist. But first, for every one hour of testimony there are roughly three hours of lawyer bickering over the scope of the testimony and today is no different!

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Trefz argues for expert testimony on the accuracy of the tests since they’ve been run on different methods. “If a patient is going to testify about their allegedly inaccurate tests, we should get to explore the depths of that patient’s knowledge as to what the test results mean.”

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Bostic notes that he’s not certain whether the doctor will testify because they’re trying to “streamline” their case and the witness list because of time concerns.

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Trefz is arguing that the confusion comes from the way the results were presented, not the actual results themselves. Bostic says her doctor’s concern about the accuracy of the results was “inadmissible hearsay.”

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Sounds like Tompkins’s doctor is also going to testify. The judge has also made a not very pleased reference to the case’s “untoward delays.”

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Bostic argues that he believes the doctor was in disbelief and had skepticism over the accuracy of the results. It wasn’t him saying that the results were accurate yet she wasn’t positive.

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The jury and Tompkins have left. Trefz is arguing that the patient was told at the time by her doctor that this was not an indication of a positive test result.

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We also see test results from August of this year that says she is negative. In cross-exam, Holmes lawyer Katie Trefz asks how much her Theranos test cost. Tompkins doesn’t remember but says she got a refund about two years later.

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We see a copy of her Theranos blood test results stating that Ms. Tompkins had HIV antibodies. She testifies that she has never had HIV or AIDS, and a different test a few months later said negative. She tried to call Theranos to get more information but spoke to no one.

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She chose Theranos for a blood test her doctor ordered because it was cheap and she didn’t have insurance. “Is there any benefit to you with blood test results that were not accurate or reliable?” Tompkins: “I can’t imagine, no.”

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She testifies first saw an article about Theranos in Forbes, she said she also heard about it on Facebook — a rec from a friend who was trying to find affordable health care options for people without insurance.

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The U.S. has called Erin Tompkins, a Theranos patient.

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Leach: “Did you think one of the risks here was that the founder and C.E.O. was not being truthful to you?” Grossman: “We did not think that was one of the risks.” And that’s it for Grossman. Wowsy!

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A major theme seems to be EXECUTION RISK. Was Theranos past the point of “proof of concept”? Should investors have anticipated the risk of the technology not working?

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Talking about Moore’s law. The jury is getting such an education in business terminology. A PGM email discusses how Theranos plans to drive down costs of making its devices. That wouldn’t apply to third-party devices, Grossman said.

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Leach pulls up the “bear case” projections (Wade had used the bull case projections) and asks: Have you ever seen a company miss its revenue projections by over $1 billion? BG: “It’s unusual.” Was that a risk you thought you were taking with this investment? BG: “Not in 2014, no.”

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This is related to Wade’s argument that PFM’s revenue projections for Theranos were overly rosy. (Grossman has testified that they were based largely on Theranos’s own projections.)

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Prosecutor Leach is back up for redirect. Leach asks: Who was in a better position to judge Theranos’s projected revenue for 2014 and 2015, you or the company? Grossman: The company.

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Wade: Was part of investing in Theranos a part of your desire to get information for your investment in Walgreens? Grossman: No. Wade: Is it true that after you invested in Theranos you started trading Walgreens stock? Prosecution objects and is sustained. And that’s it, finally!

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Wade is showing Grossman a slide deck presented by Theranos and is pointing out that many of the claims were “aspirational.”

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OK, just before the break my laptop died, but Judge Davila expressed the most frustration I’ve ever seen over how long Wade’s cross-exam is lasting (6+ hours).

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Wade points out that the presentation doesn’t include the accuracy risks or highlight the “limited operating experience” Theranos had.

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So Grossman delivered a presentation to some other investors summarizing PFM’s own research about Theranos. It has Theranos’s logo on the front of it and Wade asks “did you get Theranos’s permission to use their logo?”

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Grossman quotes from lower in the email that his firm’s expert continued to believe these risks were acceptable for investing. There’s also a cryptic email from Grossman to his teammates that simply says “real world.”

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There’s another email where someone at the firm says Blue Cross Blue Shield did diligence on Theranos and said it doesn’t work. And another one where someone is saying again that there’s a chance it won’t pass FDA review.

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Erin Griffith

Another email from Grossman’s internal expert outlining more risks on the tech. Says he doesn’t think Theranos has enough data to get FDA approval. The takeaway from these hours of cross-exam from Grossman seems to (still) be: You knew about all these risks and still invested.

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We get another “if that’s your question, then yes.” Grossman is patiently describing in great, great detail all of the analysis PFM did on its financial models on Theranos. The room is getting restless. Not even sure Wade is enjoying this level of detail.

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Wade tries to make the point that PFM’s revenue projections for Theranos were unrealistically high. Grossman says no and gives the example of Moderna. “They tend to be really important, open-ended technology, very disruptive, that have a big impact on society.”

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A few more comps added to the analysis: Salesforce, Tesla and a few others I didn’t hear. Grossman repeats his line about “open-ended, disruptive technology platform companies”

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(The third comp Grossman suggested is Illumina.)

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Describing comps, Grossman testifies they were trying to find “open-ended, best-in-breed disruptive companies.” Wade then tries to call FB and GOOG “unicorns.” I feel personally trolled.

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Erin Griffith

To justify the valuation they suggest using Google and Facebook as comps to Theranos!?!? To use a Grossman term… Wowzers

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We see an email between Grossman and his partner James — no mention of bevies — where Grossman says the valuation and terms “are obviously tough to swallow.” But his call with Channing Robertson was “mind-blowing” and gave him a lot of confidence.

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Post break, Wade is asking Grossman about his conversations with Channing Robertson. Grossman’s father-in-law, David Brady, knew Robertson, was a politics professor at Stanford and was involved with Hoover Institution. Brady also invested in Theranos.

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We have spent … a lot of time going through every painstaking detail of Grossman’s diligence. It is a lot, and I’m not 100 percent sure what effect this is meant to have on the jury.

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We see an email that shows PFM confirms that any device outside a CLIA lab needs to FDA clearance. Theranos often said they didn’t need FDA approval for their machines in stores because the “analysis” would be done in the cloud / in its CLIA lab.

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Grossman has not been asked about why PFM ultimately decided to invest despite all of his very diligent diligence and the doubts raised inside the firm.

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The email also notes that Theranos’s projections are “a bit aggressive” but “with excellent execution are doable and can be exceeded.” Point to show that Grossman knew the risks of backing Theranos.

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Erin Griffith

More internal PFM emails! This one is about a health care conference where PFM’s tech expert planned to vet Theranos’s tech with others in the industry without violating NDA. Also says he thinks Theranos’s technology is “very good” and has IP and competition concerns.

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Erin Griffith

To get around this Grossman answers a lot of Wade’s questions with “If the question is X [narrator: it is not], then the answer is Y.”

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Erin Griffith

Lance Wade is questioning Grossman about a certain document that is not in evidence and Grossman is refusing to acknowledge that it “refreshes his recollection” because he believes Wade’s questions are misleading.

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Erin Griffith

🩸 It’s U.S. v. Holmes again. 🩸 Brian Grossman, managing director at PFM Health Sciences, which backed Theranos, will continue cross-examination today.

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Erin Griffith

Grossman and jury are dismissed for the day and its time for our usual lawyer chat. Downey wants to talk about an issue in camera and the judge is lightly ribbing Wade for how long his cross-exam is going. Back tomorrow!

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Erin Griffith

Wade continues to press this point which is a question I have too — Grossman did all the right stuff regarding diligence, and yet he still invested.

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Erin Griffith

Wade hits Grossman over the fact that he invested in Theranos even after the refused to let him talk to Walgreens or United in diligence. Grossman says that forced his firm to rely on information from Theranos.

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Erin Griffith

We now see a PFM email summarizing the Theranos discussion during a Walgreens earnings call. Point being that PFM took other information into account beyond what Holmes said to decide on the investment.

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Erin Griffith

We got a brief glimpse of an email from Grossman re WAG and Theranos: “Wowzer. That’s quite an endorsement.”

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Erin Griffith

We see some emails between Grossman and some of his analysts about Walgreens and Theranos. They are discussing Cowen’s take on the Theranos / WAG partnership. Wade suggests Cowen analyst reports are a respected source of information. Grossman says that’s “debatable.”

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Erin Griffith

Elsewhere on this email thread Grossman asks his partner, “What time u picking us up? U want us to brink bevies for the drive?”

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Erin Griffith

Wade is now taking Grossman through the team of people at PFM who worked on the deal, explaining their expertise. He mentions Philippe Laffont of Coatue, who introduced PFM to Theranos. We see an email from Laffont to Chris James, an investor at PFM, saying Theranos is “one of the most impressive boards I’ve ever seen.” James forwards the email to Grossman with one word: “Wowsy”

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Erin Griffith

Wade appears to be doing his bore-em-to-death thing going into tedious detail about the mechanics of private market investments.

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Erin Griffith

Wade asks Grossman to define a hedge fund and he runs down all the various attributes ending with “and obviously, a hedge fund can hedge.” Somewhere Carol Loomis is smiling.

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Erin Griffith

Lance Wade is up for cross-exam. Unlike with past investors, who Wade attempted to discredit by criticizing their lack of diligence, the strategy here seems to be building up how much diligence Grossman’s firm did.

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Erin Griffith

At the very end we saw that Grossman’s firm invested $96 million across several funds.

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Erin Griffith

We see internal Theranos emails discussing Grossman’s results. He is a “VIP” and they push to get his results out quickly. The results appear to be run on a third party machine, which Balwani never told him about.

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Erin Griffith

Balwani blamed a rare test and a lab failure. Thanked him for “highlighting this issue.”

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Erin Griffith

I believe Grossman is the only investor we’ve heard from who went to a Walgreens to get his blood tested on his own. Afterward he asked Balwani why he had to have a venous draw (no fingerstick) and why it took more than 4 hours.

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Erin Griffith

Grossman spoke to Channing Robertson (Theranos board member, former Stanford professor) twice. Robertson said Theranos had no technical risk and that its technology inside the MiniLab was sound.

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Erin Griffith

Grossman also wanted to talk to United Healthcare, which (apparently) had a contract with Theranos. Similar to Walgreens, Balwani said no. “It will look badly on us, if investors are asking to speak to someone at the company.”

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Erin Griffith

Grossman asked to talk to Walgreens and Sunny Balwani told him he was “very uncomfortable” with that. He told Grossman it “would be a strange conversation, they have a great relationship, it wouldn’t look good.” “He had a series of responses along those lines.”

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Erin Griffith

So we have walked through the same slideshow that Theranos presented to most of its investors including being “comprehensively validated by pharma companies.

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Erin Griffith

Grossman: “They were emphatic that this was not another point of care testing company. This was the entire laboratory shrunk down into a box.”

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Erin Griffith

Grossman said he saw various different versions of the Theranos blood testing machines at their manufacturing facility in Newark, at their CLIA lab in Palo Alto and in the lobby of their California St. office.

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Erin Griffith

Or at least attempted diligence. Holmes and Balwani answered the questions in meetings. It appears we are going to go through their spoken answers on every one of these questions (there are many…).

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Erin Griffith

Grossman had three analysts working on the deal and says “there’s a lot of analytic labor” that goes into his firm’s modeling. This appears to be the most diligence that any Theranos investor has done so far…

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Erin Griffith

We see an email from Grossman to Holmes and Balwani containing due diligence questions. There are seven areas of question (technology, IP + barriers to entry, Regulatory, Financial Model/Projections, etc.) with lonnnnnng lists of detailed questions for each.

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Erin Griffith

Grossman testifies: “Ms. Holmes was actually very clear that they could match every test on the Labcorp and Quest menu of tests.”

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Erin Griffith

Grossman goes into a very long and detailed tale of the claims Holmes made to him about Theranos’s technology and business. She told him the usual: Theranos was more reliable than Labcorp/Quest and they worked with pharma companies and on medevacs on the battlefield.

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Erin Griffith

Grossman met with Balwani and Theranos at its lab in December 2013. He testifies that the security to enter the building, including its NDAs, was unusually strict.

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Erin Griffith

Grossman offers up a little lesson on limited partners. PFM’s include pension funds. Hey jury, it’s not just rich people who were burned by Theranos!

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Erin Griffith

Yam is excused. The U.S. has called Brian Grossman, a managing partner at PFM Health Sciences, a San Francisco firm that runs a hedge fund and growth equity fund.

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Erin Griffith

Lance Wade is questioning Yam on whether the wire transfers discussed in the email actually happened. Can’t we just … verify that somewhere?

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Erin Griffith

$1.1 million to be precise, wired to Horizon Media, the marketing firm. This is one of the wire fraud counts outlined in the indictment.

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Erin Griffith

We see a late 2015 email regarding expenses for an ad campaign (TV, print, etc.) in the millions of dollars in Arizona.

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Erin Griffith

The prosecution has called Danise Yam, a.k.a. So Han Spivey, likely to reintroduce a certain email.

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Erin Griffith

And Alan Eisenman has left town. So we will be getting a new witness this morning.

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Erin Griffith

Judge Davila says he sees nothing to disturb the court’s previous ruling on this issue. Glad we just spent an hour debating it!!

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Erin Griffith

Bostic further argues that Holmes had “better sources of information” about Theranos results … from her own lab. And “if positive information is admissible just because Holmes saw it, then negative information that Holmes saw should also be admissible,” i.e., the 2015 WSJ article.

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Erin Griffith

Judge further notes that there are lots of comments from phlebotomists, who were employees of Theranos. John Bostic argues that the patient reviews aren’t relevant. The reports were only sent to Holmes in 2015, and the majority of the investments in the case happened before that.

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Erin Griffith

Judge Davila is skeptical. He said the majority of the customer comments talk about pricing because they had no health insurance. Or they were given $100 gift cards by doctors. Not about the accuracy of the tests.

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Erin Griffith

Now Holmes lawyer Richard Cleary is arguing the defense should be able to include testimony of positive reviews / surveys of Theranos tests.

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Erin Griffith

🩸U.S. v. Holmes again. 🩸 The lawyers are fighting about whether to discuss the lost database of Theranos tests.

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Erin Griffith

Ok that’s it for today — short day. Buckling in for four more days of testimony!

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Erin Griffith

We’re not done with Eisenman as there is still a matter to debate about his notes. The defense wants a color copy so they can examine all the various inks used. 🎨

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Erin Griffith

In cross-exam Downey had discussed how much Eisenman’s stock in Theranos was worth. In redirect, Bostic asks: What is your understanding that your stock in Theranos is worth today? Eisenman: “It’s not an understanding, it’s a conclusion. It’s worth zero.”

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Erin Griffith

In redirect Eisenman speaks about the contrast between the Theranos hype — all their progress and demand in the market — and the legal disclaimers that come with investing (this is a high risk growth company, you could lose all your money, etc., etc.). The power of hype is strong!

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Erin Griffith

Downey says that Eisenman has asked government agents to look into a different investment where he lost money. Judge sustains objection and that is the end of cross-exam of Eisenman.

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Erin Griffith

Eisenman says, “It’s a little misleading — we are on the same page because I feel that I was lied to and cheated from the company.”

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Erin Griffith

Downey asked Eisenman about his relationship with the prosecution. He gives squirrely answers and we eventually see an email from 2018 where Eisenman says “You know that I am a faithful part of your team and will do all that I can to help your case.”

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Erin Griffith

We are back to the legal boilerplate fight. Eisenman refuses to answer yes/no questions about it. And remember: legal disclaimers are there for a reason! They will be used against you in court!

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Erin Griffith

Defense counsel Downey: “As I suspected there are some indications in the notes that the notes are not what Mr. Eisenman described in his direct examination. … At some point additional info has been inserted in a different color ink.”

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Erin Griffith

During our break (is it too early for lunch?), the lawyers from both sides are going to review the notes that defense filed a subpoena for in a side room.

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Erin Griffith

Another scathing email from Balwani. Eisenman emailed about a news article that says Theranos could become obsolete. Balwani: “I think these emails are beyond ridiculous.”

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Erin Griffith

Downey makes the point that Eisenman chose to invest more into Theranos, despite the fact that Balwani had “ignored or intimidated” him.

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Erin Griffith

Lots of cross-talk chaos between Eisenman, Downey, the court reporter and Judge Davila, who jumps in: “Let’s reset. It goes by question and answer. The lawyers get to ask the questions and it’s your privilege to answer them.”

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Erin Griffith

It is not great to have examples of government agents telling Eisenman “do not contact us” juxtaposed with emails from Holmes telling him “do not contact us.”

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Erin Griffith

Over the weekend defense subpoenaed Eisenman for his notes about the Theranos investment and Downey demands he gives them to the court admin. Eisenman wants more info on the process.

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Erin Griffith

Eisenman: “I’m a smart guy.” Downey: “Did the government agree with that smart judgment?” (prosecution objects)

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Erin Griffith

Agent Hernandez called Eisenman and said to not communicate with the government about the substance of the trial. Eisenman then apparently sent another email to the government the next morning and the government called *again* with Mr. Bostic, saying not to communicate with them.

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Erin Griffith

We were going to see the email he sent to Agent Hernandez on the prosecution’s team offering “some reflections” on his testimony, but prosecution objected to admitting evidence that was 90{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} redacted.

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Erin Griffith

Downey: “How long did it take you to violate that directive? Was it less than about 15 hours?” Eisenman: “I don’t recall.” 😬

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Erin Griffith

Uh ohhh, Downey points out that Eisenman flew back to Houston after his initial testimony Wednesday evening and immediately violated his directive to not discuss the trial with anyone.

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Erin Griffith

Eisenman also reached out to Bill Frist through his father-in-law, Joel Gordon, a wealthy political donor in Tennessee. Downey asks why he wanted that outreach to be secret. Eisenman says that comment is “misleading.”

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Erin Griffith

We see an email from Holmes to Eisenman from 2012, after he reached out to Don Lucas: “No, Alan it has been about that long since you decided to start harassing our chairman.” Eisenman says that is a “total mischaracterization.”

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Erin Griffith

The email about Larry Ellison was meant to show that Theranos was providing general information to all investors. Eisenman pushes back there, too. “There was no communication to investors generally, either” and “I don’t think they communicated that to their investor base.”

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Erin Griffith

Downey is trying to make the point that Eisenman was demanding special information. He asked whether Eisenman knows that Theranos had no legal obligation to update him with “specific” and “individual” information he was requesting.

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Erin Griffith

In 2020 Eisenman emailed Holmes asking why Larry Ellison was no longer on the board. Holmes responded: “There is no new information to be shared with our investor base.”

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Erin Griffith

Eisenman testifies that he believes Holmes was hiding information from him. Downey tries to strike that, too, and the judge says no — “that was his understanding of his opinion.”

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Erin Griffith

The same dynamic is happening today. Downey asks about general rules around sharing information with investors and he pushes back about NDAs and the specific situation at Theranos. Downey strikes several attempted answers.

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Erin Griffith

Eisenman’s direct testimony also brought up some pretty wild emails between him and Holmes+Balwani. They basically treated him like a stalker for asking for more info and threatened legal action. And then, incredibly, he still invested more $$ after that!

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Erin Griffith

Eisenman was a difficult witness for the defense lawyers. He refused to go along with some of Kevin Downey’s yes/no questions and it got testy.

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Erin Griffith

🩸 “Our Holmes Matter” continues. 🩸 Full week of testimony in U.S. v. Holmes after last week’s announcement that the prosecution is likely to rest soon. Alan Eisenman, a Theranos investor, returns to the stand for cross-exam.

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Erin Griffith

Wrapping up. That’s all the blood for the week. Next week we’re going all five days! 🩸🩸🩸🩸🩸🩸🩸🩸🩸🩸🩸🩸🩸

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Erin Griffith

This is why boilerplate exists! It can (and will) be used as a weapon in court.

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Erin Griffith

Twice in a row, Eisenman goes on a rant that “this is what they call a boilerplate as you know” and Judge Davila cuts him off, telling him to answer the question asked. “I’m trying,” Eisenman says.

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Erin Griffith

Downey pulls up Eisenman’s investment agreement with Theranos which contains a legal disclaimer saying the company made “no assurances” it would ever go public. Eisenman pushes back that Holmes told him Theranos was talking to Morgan Stanley about an IPO in the next year.

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Erin Griffith

Eisenman: “Can I ask you what a ‘service frame agreement’ is? I don’t know what that means” Downey: “You cannot.”

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Erin Griffith

Kevin Downey, Holmes’s lawyer, is cross-examining Eisenman. Raising his voice a bit asking about his investment experience and about his conversations with Holmes. Pointing out that Eisenman only had one short call with Holmes before investing.

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Erin Griffith

Eisenman emails again asking for more info about potentially selling his shares. Balwani’s response: “Your emails are insulting full of inaccurate statements and wasteful of our time. Our next response to this email and all your future emails will come from our counsel.”

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Erin Griffith

Guy was told an IPO was coming almost a decade earlier and now can’t get a call back. He is now sending emails with PLEASE RESPOND!!! in the subject lines. And Balwani responds with “I already responded to you”

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Erin Griffith

Eisenman responds asking for more info and Balwani responds with this: Alan. I have no intention of responding to this email and explaining the tech and processes. Please stop sending me with emails everyday. thanks.

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Erin Griffith

Eisenman emails Holmes and Balwani a negative UBS report about Theranos. Balwani responds that it “sounds like an uninformed consultant”

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Erin Griffith

And despite all that, Eisenman STILL invested $99,990 into Theranos in 2013. Why? “This is called a seat at the table.”

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Erin Griffith

Before it was fundraising, Eisenman testifies that Sunny Balwani was “not only nonresponsive but aggressive with me.” “To say minimally, he was hostile for an extended period of time.”

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Erin Griffith

Then Theranos was raising money again and it sounds like *despite all of this drama* Eisenman was willing to invest more money!

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Erin Griffith

He responded: “It has been over 2 years since you have communicated with your investors. … Does this mean that you can’t or won’t communicate with me or the other investors?

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Erin Griffith

From there things got spicy. Eisenman reached out Don Lucas asking for information. Lucas forwarded it to Holmes and she responded: “Alan, we have communicated about this multiple times before yet you choose to continue going down this path. Elizabeth”

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Erin Griffith

In a May 2010 email, Eisenman asks Holmes whether the company hit the $200m revenue it predicted for 2009. In a later email, he testifies, Holmes said that goal was “stretched another year.”

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Erin Griffith

His push for more information about Theranos’s performance frustrated Holmes. “I was more proactive than most. … Management didn’t like the fact that I was trying to communicate and get information.” To solve that problem, Holmes offered to buy him out at a 5x return.

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Erin Griffith

Over time Eisenman asked Holmes to keep her quarterly updates coming and was denied. “There was no information coming from the company. To me that’s a sign of trouble.”

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Erin Griffith

Theranos told investors it would become cash flow positive by the end of ’08. Now we’re going on a break.

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Erin Griffith

In ’09 Theranos was telling Eisenman about huge demand for its cartridges. “These are numbers that are pretty astounding and create a pretty significant value for this company,” he said.

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Erin Griffith

Altogether Eisenman’s family invested just under $1.2m into Theranos. ($900k for him and his wife, $90k for each of three kids) His testimony follows a pattern that is very familiar by now: What he understood about what Theranos’s technology could do and how he learned it.

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Erin Griffith

Eisenman had many one-on-one calls with Holmes and she was the main source of info on the company. In 2006 Holmes was already saying she was talking to bankers about an IPO in the next 12-18 months and claiming $50m-60m in revenue in ’07 and $200m in ’08.

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Erin Griffith

Eisenman testifies that, around 2006, he was told that Larry Ellison was on Theranos’s board and was taking $20 million of an upcoming $30 million fundraise. “My understanding was these international pharma companies had adopted this tech in some of their clinical trails.”

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Erin Griffith

Alan Eisenman, a Theranos investor, is now on the stand. He was introduced to the company by the Holmes family’s financial adviser in Houston.

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Erin Griffith

Das testimony ends with a very awkward exchange where Wade prompted him to recall a quote from the Best Exotic Marigold Hotel. “Everything will be alright in the end and if it’s not alright, it’s not yet the end.” Why was that relevant? I dunno.

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Erin Griffith

Defense has spent time in testimony painting Holmes as an inexperienced person who could never have understood the details of how a lab works. Prosecution pointed out that she was CEO of the company and touted the patents she claimed to have written.

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Erin Griffith

We also heard more about the Holmes excuse for the lab problems — she blamed it on quality control issues, not the machines. Apparently that excuse was given to CMS in a letter that Das signed, even though he disagreed with that part.

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Erin Griffith

Dr. Das was asked in cross-exam about whether his decision to void the tests was “conservative.” In redirect, he was asked about it again and he said, “I was just following the data.”

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Erin Griffith

Back to cross-exam. We see an email in April 2016 from Dr. Das to Holmes titled “some good news, for once” — data from two valuations looked “excellent” he wrote, even though he was not “a fan of the studies themselves.”

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Erin Griffith

Now they’re doing a sidebar about scheduling, which I really wish would be a main bar so the press could have any sense whatsoever of what to expect and plan around…

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Erin Griffith

One issue: Eisenman, who invested in Theranos, apparently said something about punishment of Holmes in the hallway and defense is concerned about that. And secondly, they’re redacting a line from an email that says he had most of his net worth (‼️) tied up in Theranos

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Erin Griffith

During a break the lawyers are fighting over the upcoming testimony of Alan Eisenman.

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Erin Griffith

Wade makes it seem like Theranos was heroic for voiding the tests, given media scrutiny and stakes: It was a big decision to make to void all of the assays for their analyzers? It wasn’t necessarily something anyone wanted to do? The preference would be not to have to do that?

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Erin Griffith

Now Wade attempts to blame former lab director Adam Rosendorff (without mentioning that he resigned in frustration and leaked to WSJ). You recall the laboratory was not well-run when you joined? And that was why you were working to improve it?

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Erin Griffith

Now Wade blames Das: You’re familiar with Holmes’s background and training? She wouldn’t be qualified to serve as a lab director in a high complexity lab? But you were qualified? Ultimately the judgments were yours? You were responsible for the people working under you?

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Erin Griffith

We talk about all the people working on addressing the problems. Wade: “All these people were working hard and in good faith as they were undertaking these efforts, is that fair?” Das says yes (obviously).

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Erin Griffith

Wade is deflecting blame to Sunny Balwani, who was in charge of the lab. Before Dr. Das, lab directors reported to Balwani. When Das joined, he reported directly to Holmes, and Wade elicits testimony that this was a change designed to address the issues.

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Erin Griffith

Before Dr. Das joined Theranos, CMS inspected Theranos’s labs and issued a damning report about lab deficiencies, which we saw yesterday.

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Erin Griffith

🩸 “Our Holmes Matter” continues in San Jose. 🩸Holmes lawyer Lance Wade is questioning Dr. Das, Theranos’s final lab director. Yesterday he testified that he decided to void as many as 60k Theranos tests.

‘Cupping’ technique could improve vaccine delivery

‘Cupping’ technique could improve vaccine delivery
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Inspired by ancient medicine, experts have tested a new technique to improve vaccine delivery. Pansfun Images/Stocksy
  • A team of researchers recently developed a novel way of delivering nucleic acid-based medicines using a method similar to an ancient cupping technique, Home Garden USA.
  • Their experiments indicate that the technique makes vaccine delivery more effective by several orders of magnitude.
  • The cupping technique is currently undergoing clinical trials to deliver a COVID-19 vaccine.

Over the past 20 years, scientists have developed a range of nucleic acid-based medicines as both treatments and vaccines.

Nucleic acids are present in all living cells, most notably as DNA and RNA.

Treatments and vaccines that use nucleic acids work by inhibiting, adding, replacing, or editing DNA and RNA in host cells.

How well these treatments and vaccines work depends on how well they can be delivered to the host’s cells. If directly injected into tissue, for example, most nucleic acids will rapidly degrade unless protected.

The Pfizer-BioNTech and Moderna COVID-19 vaccines are both nucleic acid-based medicines. Nucleic acids in these vaccines are enclosed and protected by lipid nanoparticles that deliver them across the host cell membrane.

Although they are effective, drugs delivered in this way are vulnerable to degradation during storage.

One delivery method for nucleic acid-based medicines is electroporation. This involves delivering nucleic acids to cells made more permeable using a pulse of electricity.

While somewhat effective, these electrical impulses can cause muscle contractions, tissue damage, and pain, and they may not be suitable for people who use implantable electrical devices such as defibrillators or pacemakers.

Using this method also requires substantial training, and equipment costs may make it inaccessible to regions and populations with fewer resources.

Creating a method for delivering nucleic acid-based medicines that overcomes unwanted side effects and cost barriers while still being effective could increase the accessibility of vaccines to areas with limited resources.

Recently, researchers from Rutgers, the State University of New Jersey in Piscataway, and GeneOne Life Science in Seoul, South Korea, developed a method based on an ancient cupping technique to deliver nucleic acid-based medicines.

“Development of enhanced delivery technologies plays an instrumental role in bringing nucleic acid-based biologics to broad use and clinical relevance, and worldwide vaccine distribution is just one example,” said senior study author Prof. Hao Lin.

“We have demonstrated an alternative, safe, and effective transfection platform that yields high levels of transgene expression.”

“The advantages also include device cost effectiveness, […] manufacturing scalability, and minimal requirements for user training,” he added.

“Because of the inherent advantages of DNA, not least of which is avoiding cold-chain requirements of other vaccines, this technology facilitates vaccination programs into remote regions of the world where resources are limited,” he added.

The study now appears in the journal Science Advances.

Cupping therapy is an ancient treatment method from the Middle East and China. It involves applying heated cups to the skin to create negative pressure and increase blood circulation to promote healing.

Since 1950, doctors have used the method in hospitals in China and elsewhere for conditions such as acne, facial paralysis, and dyspnea.

Although evidence of its health benefits is lacking, the authors of the new study decided to investigate a similar technique as a potential delivery method for nucleic acid-based medicine.

To test the method, the researchers gathered two groups of rats and injected both with DNA in the upper layers of their skin. One group received the “suction cup treatment” on their injection site, whereas the other group did not.

The researchers monitored the activity of the DNA with fluorescence microscopy. They found that gene expression from the vaccine was detectable at 4 hours post-vaccination. In the rats who also underwent cupping, however, gene expression was detectable at 1 hour post-vaccination.

At 24 hours post-injection, the researchers saw that gene expression was detectable eight times deeper under the skin among the rats who underwent cupping than among those who received DNA injections alone.

To investigate whether or not this technology could work to deliver potential COVID-19 vaccines, the researchers next injected the rats with a synthetic SARS-CoV-2 DNA candidate vaccine.

They split the rats into three groups:

  • The first group received two injections of the vaccine candidate without suction on days 0 and 14.
  • The second group received one vaccine, followed by dermal suction on day 0.
  • The third group received two vaccinations and dermal suction on days 0 and 14.

The researchers collected blood samples from the rats on days 0 and 14, before vaccination, and again on day 29.

They found that the rats who received cupping after the vaccine had a significantly stronger immune response than those who received the vaccine alone.

The researchers also found that immune responses in the rats who received a single vaccine followed by suction were not statistically different from those who received two vaccines followed by suction.

They also note that the rats who underwent suction had no evidence of tissue damage or lymphocyte infiltration in their injected areas.

The researchers say that the underlying mechanisms for suction-enhanced delivery are not clear. They hypothesize, however, that it may work via the CG pathway. This plays a role in determining which molecules travel through membranes and enter cells.

The researchers explain that it will be challenging to confirm the underlying mechanisms of cupping due to the complexity of the processes involved and a lack of availability of drugs used for testing.

Nevertheless, the researchers say that even without mechanistic understanding, it is still possible to improve the method.

“Currently, the procedure is two-step: an injection followed by suction,” Dr. Lin told Medical News Today.

“We are working on a combination device/method to render one-step application — that is, injection and suction in a single step by a single device,” he continued. “Furthermore, we are trying to reduce suction time even further to increase patient and staff acceptance.”

When asked whether this method could work for COVID-19 vaccines, Dr. Lin said, “Theoretically, this may be possible, but we cannot answer without testing since, except for DNA vaccines, COVID-19 vaccines are delivered into the muscle, whereas this device delivers [the] vaccine to the upper layers of the skin.”

“The [suction] device is being tested currently in phase 1 and phase 2 clinical trials of a COVID-19 vaccine. The documentation to enable filing with regulatory agencies for general and widespread clinical use is being readied,” he said.

The researchers conclude that cupping is a promising method for nucleic acid-based medicine delivery. However, further research is necessary to see whether it could work to deliver COVID-19 vaccines to humans.

“The suction device has numerous advantages relative to other devices for DNA vaccine delivery. First, it is very inexpensive and easy to use, requiring minimal training,” Dr. Lin told MNT. “Secondly, the device is run from a battery that is easily rechargeable.”

“Third,” he continued, “is the high degree of patient acceptance, as the device will help deliver DNA vaccines without pain or discomfort.”

“And fourth, unlike the significant setup times with other devices, this only requires changing out a cap and then pressing the power button; the machine will turn off in a few seconds.”

“This, coupled with the many advantages of DNA as a vaccine type — the greatest advantages being the ability to completely avoid the need for freezers from the clinician’s perspective, and low side effects and discomfort from the patient’s perspective — makes this an ideal vaccine platform for resource-limited and remote regions,” he concluded.

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Statement by President Biden on Today’s Economic News

Today, we gained two parts of economic information which underscore that our restoration is continuing to development, but that we also have much more perform to do ahead of our economy is back to regular.

Very first, on work, we figured out that we have experienced 6 consecutive months of drop in new unemployment claims. The variety of workers shedding their employment is at the cheapest degree since the pandemic started. Unemployment statements are down 70{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} given that I took office. Unemployment has fallen so considerably this yr at the swiftest price since the 1950s. It’s a jobs restoration that has took place several years speedier than immediately after the Great Economic downturn of 2008. The usa is receiving back to get the job done.

And, on inflation, today’s report reveals an raise over very last month. Inflation hurts People in america pocketbooks, and reversing this pattern is a top precedence for me. The major share of the maximize in price ranges in this report is owing to mounting strength costs—and in the couple of days because the info for this report had been collected, the rate of purely natural fuel has fallen. I have directed my National Financial Council to go after signifies to check out to even further lower these expenses, and have questioned the Federal Trade Commission to strike back again at any market place manipulation or price tag gouging in this sector. Other selling price raises reflect the ongoing battle to restore clean functions in the economic system in the restart: I am travelling to Baltimore nowadays to spotlight how my Infrastructure Monthly bill will bring down these charges, lessen these bottlenecks, and make items far more out there and less highly-priced. And I want to reemphasize my commitment to the independence of the Federal Reserve to observe inflation, and choose methods vital to combat it.

Going forward, it is essential that Congress move my Make Back again Greater system, which is absolutely compensated for and does not insert to the debt, and will get a lot more People in america working by minimizing the expense of boy or girl care and elder care, and assist specifically reduce costs for American people by giving a lot more reasonably priced health and fitness protection and prescription drugs—alongside chopping taxes for 50 million Americans like for most family members with young children. 17 Nobel Prize winners in economics have said that my program will “ease inflationary pressures.” And my strategy does this with out raising taxes on all those making a lot less than $400,000 or adding to the federal personal debt, by demanding the wealthiest and major companies to start to shell out their good share in taxes.

We are producing progress on our recovery. Positions are up, wages are up, house values are up, individual financial debt is down, and unemployment is down. We have additional function to do, but there is no query that the economic climate carries on to get better and is in a great deal far better form today than it was a year back.

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Today’s coronavirus news: Health Canada authorizes the use of the Pfizer vaccine as a booster shot; Ontario reporting 441 new COVID-19 cases

The latest coronavirus news from Canada and around the world Tuesday. This file will be updated throughout the day. Web links to longer stories if available.

4:10 p.m.: Ontario will “stay the course” with its less restrictive COVID-19 measures despite a 41 per cent increase in infections over the last 10 days, and leave local health units to deal with flare-ups for now, says Health Minister Christine Elliott.

“We know that the numbers have gone up somewhat. We anticipated that would happen,” Elliott told reporters Tuesday as the seven-day average of new cases rose for the tenth day in a row and the province reported 441 more people testing positive for the virus.

“So what we’re seeing right now are largely regional outbreaks which we’re going to be dealing with regionally.”

Read the full story here: Ontario will ‘stay the course’ with current COVID-19 restrictions despite surge in new cases, Christine Elliott says

3:45 p.m.: Health officials in Nova Scotia are reporting one new COVID-19-related death as an outbreak of the disease in a long-term care home continues to grow in another part of the province.

The Health Department says a man in his 80s in the province’s eastern zone has died and 56 new cases of the disease have been identified since Monday.

Officials have also noted community spread of the disease in the northern and western regions of the province, largely related to transmission of the virus during a multi-day faith gathering.

The gathering has been directly connected to the ongoing outbreak at East Cumberland Lodge, a long-term care home in Pugwash, as well as transmission at other faith services and in workplaces.

Thirteen more residents at the home and a second staff member have tested positive for the disease, bringing the total case count at the residence to 19.

The province now has 281 active cases of COVID-19, with 10 people in hospital and two in ICU.

3:30 p.m.: Quebec is expanding eligibility for COVID-19 vaccine booster doses to the general population aged 70 and older, Health Minister Christian Dubé said Tuesday.

Third doses of mRNA vaccines will also be available by the end of the month to residents who received two doses of the Oxford-AstraZeneca vaccine, Dubé added. Those residents will need to wait six months from their second doses for a third shot.

“I want to reassure the population, it’s not because we are worried about AstraZeneca, it’s because we want to make sure there’s an extra protection — especially after six months,” Dubé told reporters.

The government made the decision following recommendations by Quebec’s immunization committee. Despite Health Canada announcing on Tuesday it authorized boosters for all adults, Quebec said it would stick to its plan. Public health director Dr. Horacio Arruda told reporters the government preferred to follow the recommendations of its vaccine committee.

“Even if there is a recommendation from Canada, we refer almost all the time to our own committee because they are aware of our own epidemiology,” Arruda said.

Starting Nov. 16, people aged 80 and older will be able to book an appointment for a third dose, followed by people 75 and up two days later and then residents 70 and older on Nov. 23. Residents of any age who received the AstraZeneca vaccine can start booking third doses on Nov. 25. All groups must wait six months since their second doses to book a third shot.

In late September, the province announced it would offer people in long-term care homes and seniors residences booster shots to prevent outbreaks among vulnerable residents. Since August, Quebec has offered a third dose of COVID-19 vaccine to people who are severely immunocompromised.

For the general population, protection from two doses after six months remains high — especially against severe infection and death, according to Dr. André Veillette, an immunologist at the Montreal Clinical Research Institute. Veillette, however, said protection will inevitably start to decline.

“Some people will say it’s not a problem, because of what we call memory cells,” Veillette said in an interview on Monday. “That’s when your antibodies are low, then the memory cells are activated if you get infected, and then a week later, they will make a lot of antibodies.”

The problem, he said, is that for some people — and maybe eventually for everybody — a week of infection is too long to wait for the antibodies to kick in.

Veillette said the government’s immediate priority should be identifying high-risk groups and giving them third doses. He also said he believes boosters will eventually be available for all Quebecers, even for young people.

“We have billions of doses in Ottawa waiting on shelves, and tens of millions more have been bought for next year by the government,” Veillette said. “The vaccines are available.”

Arruda, however, said there is no need yet to offer a third dose to people under 70 years old.

“For the others that are healthy, and under 70, there are no recommendations for a third dose,” Arruda said. “Two doses are still a good thing.”

Meanwhile, Quebec reported 545 new cases of COVID-19 on Tuesday and six more deaths attributed to the novel coronavirus. Health officials said COVID-19-related hospitalizations dropped by six, to 219, and there were 45 people in intensive care, a drop of three.

The Health Department said 9,406 vaccine doses were administered in the previous 24 hours. Quebec’s public health institute said about 90.8 per cent of residents aged 12 and older have received at least one dose of COVID-19 vaccine and 88.2 per cent are considered adequately vaccinated.

Quebec has 5,219 active reported cases of COVID-19.

2 p.m. Packers quarterback Aaron Rodgers remains upset with the public’s reception to his admission that he is not vaccinated against COVID-19, according to People.

Rodgers tested positive for COVID-19 last week before missing Green Bay’s loss to the Chiefs on Sunday. Rodgers previously indicated he was vaccinated in an August press conference, telling the media when asked about his status, “I’m immunized.”

Green Bay’s signal-caller made an appearance on The Pat McAfee Show on Friday to address the apparent obfuscation, a segment that featured misinformation on both COVID-19 and vaccines. Rodgers now feels as though he’s “being crucified” for his remarks, per People.

1:34 p.m. Canadians are scrambling to get mortgage pre-approvals and rate holds as economists predict the pandemic-long stretch of low interest rates will soon end.

Estée Zacks says she recently noticed a surge in requests for rate holds, which freeze mortgage rates for up to 130 days.

The owner of Strategic Mortgage Solutions Inc. says her clients see the holds as a way to get a leg up on hot markets like Toronto that are favouring sellers.

CIBC Capital Markets analyst Benjamin Tal says even a one per cent increase in mortgage rates from current levels will cost an average new buyer $230 or 12 per cent more in additional monthly interest payments.

BMO Capital Markets senior economist Robert Kavcic says five-year fixed mortgage rates are already creeping higher, but people with pre-approvals in hand probably have another month or two to buy a home.

1:20 p.m. Quebec needs to quickly provide a coherent plan on how it intends to offer third doses of COVID-19 vaccine to the general population, Dr. André Veillette, an immunologist at the Montreal Clinical Research Institute, said Monday.

The province announced in late September it would offer people in long-term care homes and seniors residences booster shots to prevent outbreaks among vulnerable residents. Since August, Quebec has offered a third dose of COVID-19 vaccine to people who are severely immunocompromised.

While boosters for the general population weren’t part of the National Advisory Committee on Immunization’s recommendations at the end of October, provinces such as Ontario and British Columbia have already announced plans to expand eligibility for third shots.

1 p.m. Ontario plans to spend $12.4 million on more mental health and addictions supports for front-line health-care workers.

The province says $5.9 million will go to services offered through hospitals such as self-referral and intake services, online discussion groups and confidential clinician support.

There is also $1.9 million allocated for psychologist services specializing in trauma, anxiety and other conditions and $4.6 million for workplace mental health training.

12:45 p.m. Ontario’s health minister says the government isn’t changing course on its reopening plan despite a recent rise in COVID-19 infections.

Health Minister Christine Elliott says a bump in cases was anticipated during the colder weather as people move indoors, and that was factored into the province’s plans.

Experts told The Canadian Press this week that cold weather and the lifting of provincial crowd restrictions on some venues like stadiums and restaurants might be behind the growth in cases.

Tuesday saw 441 new cases reported in the province and seven-day average of 492 daily infections, up from 371 a week ago.

11:35 a.m. (updated) Health Canada has approved a booster of Pfizer-BioNTech’s COVID-19 vaccine for people over the age of 18.

The booster is designed to help people with their first two COVID-19 vaccine doses maintain their protection against the virus over time.

The booster is identical to the regular Pfizer-BioNTech vaccine, and is to be administered at least six months after the first two vaccine doses.

Different provinces have employed different rollout strategies for booster doses, and mRNA vaccines like Pfizer-BioNTech have already been used to offer longer-lasting protection to high-risk people in several parts of the country.

The National Advisory Committee on Immunization says there is no evidence of waning protection against over time against severe COVID-19 in the general vaccinated population.

11:22 a.m. Conservative MP Marilyn Gladu is apologizing for sharing misinformation about the severity of COVID-19 and the safety and efficacy of vaccines.

In a statement Tuesday, Gladu called her remarks “inappropriate.”

“Upon reflection, I recognize how dangerous it is to share misinformation about the severity of COVID-19 and the safety and efficacy of vaccines,” she said.

“I retract these comments in full.”

Read the full story from the Star’s Stephanie Levitz

11 a.m. India’s coronavirus crisis, which was killing thousands of people a day just seven months ago, has eased after the nation’s leaders revamped their policies and dramatically ramped up their vaccination drive.

Now, as India celebrates the delivery of its 1 billionth dose, a feat that until recently seemed improbable, public health experts are sounding a new warning: The turnaround is losing steam.

Vaccinations are slowing down. As the temperature dips amid India’s most important festival season, people are crowding markets and hosting unmasked friends and family indoors. And the government is telling vaccination campaign volunteers like Namanjaya Khobragade that they are no longer needed.

“Now is not the time to let our guard down,” said Khobragade, a coordinator for a health nonprofit in the eastern state of Jharkhand. “Many people have taken just the first vaccine. We cannot leave them like this. We need to increase the intensity.”

10:15 a.m. (updated) Ontario is reporting another 441 COVID-19 cases and three more deaths, according to its latest report released Tuesday morning.

Ontario has administered 13,049 vaccine doses since its last daily update, with 22,637,009 vaccines given in total as of 8 p.m. the previous night.

According to the Star’s vaccine tracker, 11,539,002 people in Ontario have received at least one shot. That works out to approximately 88.5 per cent of the eligible population 12 years and older, and the equivalent of 77.6 per cent of the total population, including those not yet eligible for the vaccine.

Read the full story from the Star’s Urbi Khan

10 a.m. A giant gap exists in Waterloo Region’s defences against COVID-19. About 126,000 residents are not yet vaccinated, giving the virus plenty of opportunity to spread through the community.

“This is equivalent to an entire mid-sized city such as Cambridge or Waterloo not being immunized,” medical officer of health Dr. Hsiu-Li Wang told regional council at Tuesday’s meeting.

Almost 44,000 people over 12 are not immunized. Almost 82,000 children under 12 are not yet eligible to get the vaccine.

9:45 a.m. The vast majority of staff members at Waterloo Region’s and Guelph-Wellington’s long-term- care homes are vaccinated, with the average staff vaccination rate in the neighbouring public health units sitting at 89.8 per cent, according to Ministry of Ontario data, last updated on Oct. 1.

The Ontario Ministry of Long-Term Care updates data on a monthly basis, typically in the middle of the month.

But with the provincial government issuing a vaccine mandate that takes place Nov. 15 and third-dose booster shots now available for all long-term care workers, almost all long-term care homes in the region will need to work on getting their staff 100 per cent vaccinated.

9:30 a.m. The health board governing Quebec’s Nunavik region says the COVID-19 situation in the northern territory is worse than it’s ever been.

Health officials reported 30 new cases Monday across the region, which is home to 14 Inuit communities.

The territory has 259 active reported cases.

Quebec’s public health institute says Nunavik is the most affected part of the province, with about 1,450 active COVID-19 cases per 100,000 people.

9:13 a.m. Book sales have thrived during the pandemic after initial concerns that it might hurt the publishing business. Come the holidays, some new nonfiction might hit your gifting sweet spots.

9 a.m. Hospitals in the southern Dutch province of Limburg warned the government Tuesday that they can no longer cope with new COVID-19 patients amid soaring rates of coronavirus infections.

Five hospitals in the province that borders both Belgium and Germany raised the alarm in a statement that said: “We are heading straight for a healthcare blockage and the entire system is grinding to a standstill.”

They added that, “we are convinced that other parts of the Netherlands will soon follow.”

Amid an autumn surge across much of Europe, the seven-day rolling average of daily new cases in the Netherlands has almost doubled over the past two weeks from 30.88 to 61.12 new cases per 100,000 people despite more than 80 per cent of the adult population being fully vaccinated.

8:45 a.m. The morgue in Romania’s main hospital has no space for the dead any more. In a stark illustration of the human cost of the coronavirus surge sweeping the nation, bodies of COVID-19 victims, wrapped in black plastic bags, line a hallway of the hospital in the capital, Bucharest.

Hundreds of people have been dying each day for the past two months in Romania which has been among the hardest-hit in the current virus onslaught raging through Central and Eastern European nations, where far fewer people have been vaccinated than in Western Europe.

A country of 19 million people, Romania currently has among the highest death rates in Europe. Last month the World Health Organization sent a team to help with the nation’s pandemic response.

8:30 a.m. A player on Germany’s national soccer team has tested positive for the coronavirus and four more are in quarantine as a precaution ahead of World Cup qualifying games against Liechtenstein and Armenia.

The German soccer federation said Tuesday that the unnamed player was fully vaccinated and does not have any symptoms. The other four tested negative for the virus but have been instructed by the local health authority in Wolfsburg to isolate because of their proximity to the infected player.

Germany has already qualified for next year’s World Cup ahead of its final qualifiers. The team hosts Liechtenstein in Wolfsburg on Thursday and then plays Armenia in Yerevan on Sunday.

8 a.m. Peel Public Health has confirmed seven schools in the region have active COVID-19 outbreaks. From Sept. 1 to Nov. 2, there have been a total of 31 outbreaks at schools in Peel region.

An outbreak is declared if the facility has two or more COVID-19 cases with an epidemiological link, which means at least one of the patients could have acquired the infection in the school.

7:46 a.m. Peel’s health agency is advising residents who attended a recent wedding event in Mississauga to get tested for COVID-19.

In a media release, Peel Public Health said those who attended an Oct. 29 wedding event at the Apollo Convention Centre in Mississauga were exposed to COVID-19 and should “seek immediate testing” whether they’ve been vaccinated or not.

Those who attended the event and are not fully vaccinated should isolate while waiting for test results, the release said

7:21 a.m. Wage growth, higher costs, supply chain issues, inflation — all of these issues are driving expectations of lower corporate earnings at the end of 2021 for everyone. Dennis Mitchell, CEO and chief investment officer at Starlight Capital, isn’t surprised by that. Nor does he believe the COVID-19 pandemic fundamentally changed major trends in business like the rise of e-commerce or the oversupply of physical retail space.

Shying away from shiny investments in favour of long-term stakes in great businesses, regardless of where they happen to be, is part of Starlight Capital’s strategy. In an interview with the Star, Mitchell unpacks his firm’s philosophy on great businesses, creating a diverse team, and where he sees the office real estate market going.

6:32 a.m.: Nobody wants to say here we go again, but here we are. Ontario has lived a relatively charmed pandemic life since the summer, and it appears to be over. The province’s seven-day case average has risen approximately 30 per cent in a week; vaccination efforts are stalling as we go. One rule of the virus is that unchecked, it will spread exponentially. We’re back there.

“Do you remember where we were immediately before Thanksgiving? That’s the behaviour and the extent of restrictions that is compatible with control of the pandemic,” says Dr. Peter Juni, the scientific director of Ontario’s independent volunteer science table. “So think how it was before Thanksgiving, and think about how much you were inside with other people. You shouldn’t do it more than you did then.”

If it sounds like going backwards, it is, in the province where the premier keeps saying he never wants to go back. A return to pre-Thanksgiving restrictions would mean a return of capacity limits in restaurants, bars, gyms, theatres and at sporting events, for a start. A return to pre-Thanksgiving social patterns should be achievable, if we just keep a bigger picture in mind. This can be done.

Read the full column from the Star’s Bruce Arthur.

6:20 a.m.: The pandemic’s effects on mortality have been uneven. Life expectancy dipped in most places last year, shaving 28.1 million years off the cumulative longevity in 31 countries. But residents of a handful of places that successfully kept COVID-19 at bay — including New Zealand and Taiwan — actually lived longer.

Life expectancy is an indication of how long on average people will live once their age is taken into account, provided that there aren’t any big shifts in the number of people dying in each age bracket over time. Another measure — excess years of life lost — quantifies the impact when those changes do occur, and gives greater weight to deaths that occur at younger ages.

A study of 37 countries and territories in the journal BMJ found the pandemic was a killing field in most places. More than 28 million years of life were lost in 2020 across 31 of them, with Russia, Bulgaria, Lithuania, the U.S., and Poland recording the heaviest toll, the study led by Nazrul Islam, a physician-epidemiologist and medical statistician at the University of Oxford, found.

Years of life lost in 2020 were higher than expected everywhere except Taiwan, New Zealand, Norway, Iceland, Denmark, and South Korea.

The number of years of life lost due to Covid-19 was more than five times greater than those lost from influenza in 2015, during the worst seasonal flu epidemic since the turn of the century.

6:20 a.m.: People who are fully vaccinated are 16 times less likely to end up in intensive care wards or to die from COVID-19, an Australian study found, adding to a growing body of evidence that may bolster the case for countries to treat the disease as endemic.

6:20 a.m.: The three parties in talks to form the next German government agreed on a package of measures to tackle the latest surge in cases, seeking to avoid sweeping restrictions like school closures and curfews.

6:20 a.m.: Hong Kong needs at least six months before reopening to the world, a government adviser said. The territory must finish negotiating open borders with the mainland and boost the vaccination rate, with Hong Kong and China the only places still pursuing a “Covid Zero” strategy.

6:17 a.m.: Denmark wants to again consider COVID-19 as “a socially critical disease,” paving the way for the reintroduction of a digital pass months after the label was removed and restrictions were phased out.

The move, which still needs approval in parliament, will also allow Denmark to reintroduce other restrictions if deemed necessary. A majority seems to be backing the suggestion of the minority Social Democratic government.

The pass was introduced on July 1 but removed on Sept. 10, when Denmark declared that the outbreak no longer was to be considered “a socially critical disease,” citing the high rate of vaccination.

However, Denmark has like many other countries seen an uptick in cases, with health authorities saying the number of infections and hospitalizations has risen faster than expected.

On Monday, Health Minister Magnus Heunicke said the COVID pass must apply to nightclubs, cafes, party buses and indoor restaurants but also outdoor events where the number of people exceeds 2,000.

The Danish pass app shows a QR code with a green banner if the holder is fully vaccinated or received a first dose at least two weeks ago, has recently recovered from COVID-19 or has had a negative test in the past 72 hours. A paper version is also available.

The call to reintroduce the pass was immediately welcomed by the industry.

6:15 a.m.: Residents of a New York border town say they’re eager to welcome Canadians now that the United States has eased land border restrictions, but they worry that costly COVID-19 testing rules will keep many travellers away.

On Monday, Christmas music floated down the halls of the Champlain Centre mall in Plattsburgh, N.Y., about an hour south of Montreal, where some retailers dreamt of the return of tourist dollars — perhaps in time for the holidays.

“We cannot wait to have Canadian shoppers come back,” Emily Moosmann, the mall’s marketing director, said in an interview. “We miss hearing French in the hallway; we miss seeing their faces.”

To lure shoppers back, the mall created a web page — headed by a large maple leaf — highlighting new stores that have opened, local COVID-19 test sites and special discounts for Canadian residents.

“About 30 per cent of our traffic is Canadian, so, not seeing them here, we definitely feel the impact,” she said. While there were only a few cars with Quebec licence plates in the parking lot on Monday, Moosmann said retailers were optimistic things would pick up on the weekend.

Read the full story from the Canadian Press.

6:15 a.m.: The Yukon government has declared a state of emergency and announced a series of public health rules aimed at curbing the spread of COVID-19, including a proof-of-vaccination requirement that’s set to take effect this Saturday.

The territory says it is “moving rapidly” to implement a proof-of-vaccination system for a range of settings, including restaurants, ticketed events, fitness facilities and personal services businesses, as well as faith-based and cultural gatherings.

It says the new measures also include mandatory masks in all indoor public settings and outdoor public settings where physical distancing isn’t possible, as well as capacity limits on different types of indoor and outdoor gatherings.

While the rules will be enforced starting Nov. 13, the territory says in a statement that Yukoners are “strongly encouraged” to adopt the measures immediately.