3 meal-related factors may drive caloric intake

3 meal-related factors may drive caloric intake

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According to new research, there are three top factors that contribute to caloric intake at mealtime. Image credit: Carol Yepes/Getty Images
  • Researchers investigated the effects of different meal characteristics on caloric consumption.
  • They found that meals that are eaten quickly and that contain high-energy density, as well as highly palatable foods are linked to higher caloric intake across four diets.
  • They noted that further research is needed to confirm their findings.

The rate of obesity worldwide has almost tripled since 1975. Between 2017 and 2022, obesity affected 41.9{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of the United States population.

The main cause of obesity is long-term energy imbalance — consuming more calories than the body gets a chance to burn. Research into dietary practices for weight loss is thus key for treating obesity.

Studies have shown that eating quickly and higher energy density foods — foods that have more calories per gram — is linked to greater food intake. Other data have shown that highly palatable foods may be artificially rewarding to consume.

Meanwhile, higher protein intake has been linked to increased satiety and lower energy intake. Understanding more about key dietary characteristics could aid the design of diets to treat obesity.

Recently, researchers investigated how meal characteristics affect caloric intake in four different dietary patterns.

They found that meal energy density, how quickly meals were eaten, and consumption of hyper-palatable foods influenced caloric intake.

“I am not surprised by the findings — this is what I would have expected,” Prof. Alberto Ascherio, professor of epidemiology and nutrition at Harvard T.H. Chan School of Public Health, not involved in the study, told Medical News Today.

“‘Hyper-palatable foods’ means just that — that they are designed to make you eat more. The food industry works hard to design these foods, with several tasting rounds to perfect the recipe, and the most reliable measure that you like a food is that you eat more.”

– Prof. Alberto Ascherio

The new study appears in Nature.

The researchers analyzed data collected from 35 individuals who participated in two inpatient feeding studies. All participants were aged between 18 and 50 years and had a stable weight for the previous 6 months.

During the studies, they were exposed to either minimally processed diets, which varied widely in carbohydrate and fat content, or diets with moderate levels of carbohydrate and fat that varied in ultra-processed and minimally processed foods.

Participants were exposed to two different diets with 7-day rotating menus for two weeks each. They were asked to eat as much as they wanted from each dietary condition.

All in all, the researchers had complete data for 2,733 meals, including their energy density, protein content, speed of eating, and percentage of hyper-palatable foods consumed- defined as those high in fat, sodium, fat, and sugar, or high in carbohydrate or salt.

In the end, the researchers found that energy density, percentage of highly palatable foods consumed, and eating rate all correlated with increased energy intake across all diets: low-fat, low-carbohydrate, a diet based on unprocessed foods, and a diet based on ultra-processed foods.

They found, however, that higher protein intake correlated with increased energy intake only in unprocessed and ultra-processed diets with moderate levels of carbohydrates and fat.

They further found that previous meal protein consumption was linked to greater energy intake in subsequent meals in the low-fat and low-carbohydrate diets, but reduced intake during the ultra-processed diet.

The researchers wrote that their findings suggest that energy density, eating rate, and percentage of protein and highly palatable foods consumed are important predictors of energy intake.

To understand how higher energy density foods might increase caloric intake, MNT spoke with Dr. Dana Ellis Hunnes, assistant professor at UCLA Fielding School of Public Health, who was not involved in the study.

“Energy density means how many calories are [in] a certain amount of food,” she explained. “The higher the energy density of something, the less of it you need to take in to have [a] higher calorie intake. For example, one tablespoon of peanut butter has roughly 100 calories in it versus one tablespoon of cooked oats has 15 calories.”

Kimberly Spatola, a registered dietitian at Novant Health Heart and Vascular Institute in Charlotte, NC, not involved in the study, also told MNT:

“Hyper-palatable foods also tend to be energy dense and higher in refined carbohydrates, which make it easier to eat a large amount of these foods without being truly satisfied. Speed of eating can also make a big difference in how much you eat. It typically takes about 20 minutes for the fullness signals from our stomach to reach our brain. Therefore, if you are eating a large meal in only 10 minutes, it will take some time before you actually register your fullness cues.”

When asked about the study’s limitations, Dr. Kevin Hall, section chief of integrative physiology at the National Institute of Diabetes and Digestive and Kidney Diseases at the U.S. Department of Health and Human Services, the senior author of the study, told MNT that “[t]he study is limited by the fact that it was a secondary analysis of previously published feeding trials in inpatient research participants housed at the Metabolic Clinical Research Unit at the NIH Clinical Center.

“While this environment allowed for accurate and precise measurements of food intake and provided excellent control over the food environment, it is difficult to know how our results extrapolate to more natural environments,” he cautioned.

Spatola added that the findings might also be limited due to their small patient sample size.

“Also the adults were all relatively young with the mean age being 29-31 years old, [and] fiber intake was not taken into consideration, which can greatly affect energy density consumed. […] More research would be needed to see if the patterns are consistent among other age groups,” she continued.

Dr. Hunnes explained: “As with anything in nutrition, one implication would be to consume a widely varied diet to get a wide range of caloric-density foods — such as low density from broths and salads, and high density from foods like nuts. Another implication of these findings would be that eating slowly is beneficial in terms of regulating overall calorie intake as is eating the least-processed/unprocessed foods possible.”

“When we eat unprocessed/ least-processed foods, we are getting a lot more water from the food- think fruit or vegetable rather than ‘veggie-flavored crackers,” she added.

“So, when we eat foods that are unprocessed, we eat fewer calories, and they are less calorically dense. These things all matter in terms of eating! A whole-food, plant-based diet fits this bill very nicely.”

Current Limit Switches Market [ADVANTAGES] || Business Growth and Development Factors by 2031 | Taiwan News

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10 health factors associated with Alzheimer’s risk

10 health factors associated with Alzheimer’s risk

Healthcare professional writing notes by a windowShare on Pinterest
A new analyze finds one-way links amongst wellness disorders and Alzheimer’s chance. OLI SCARFF/AFP by means of Getty Images
  • There is no efficient remedy for Alzheimer’s disease, but researchers hope to recognize early possibility aspects that medical doctors can target to prevent or sluggish its progress.
  • An observational study has now highlighted 10 professional medical ailments related with a diagnosis of Alzheimer’s illness up to 10 several years later.
  • The circumstances contain acknowledged possibility aspects for the disorder, these kinds of as depression and listening to reduction, and problems with no links to the disease, these kinds of as constipation.
  • The research does not expose no matter if these situations assistance trigger Alzheimer’s or are early signs and symptoms.

Persons with dementia working experience a progressive loss of their potential to remember, think, and connect correctly.

On the other hand, the alterations in the mind that are liable for dementia may start off many years before its consequences on cognition and habits come to be obvious.

The Planet Health and fitness Business (WHO) indicates that of the 55 million people throughout the world residing with dementia, 60–70{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} have Alzheimer’s condition.

Tries to produce an efficient treatment for Alzheimer’s have fulfilled with small good results. Researchers are progressively turning their notice to detecting the sickness early.

The vital to this tactic is to establish early, “modifiable” hazard variables that medical professionals can concentrate on with medicine or other interventions.

Researchers at the Paris Mind Institute in France have now discovered statistical associations in between 10 overall health ailments and a diagnosis of Alzheimer’s sickness up to 10 decades later on.

Main melancholy was the earliest ailment to be connected with a subsequent analysis of Alzheimer’s, appearing at least 9 many years in advance.

Other problems that the review linked to a afterwards prognosis of Alzheimer’s involved:

  • panic
  • constipation
  • abnormal fat reduction
  • a variety of arthritis termed cervical spondylosis
  • response to intense stress
  • listening to loss
  • rest issues

They also confirmed that falls and tiredness experienced hyperlinks to Alzheimer’s risk.

The subsequent move will be to identify no matter whether these problems assist trigger the condition or regardless of whether they are early indications of variations in the brain that are by now happening.

“Diseases like Alzheimer’s can commence in the mind up to 2 decades ahead of signs start off to display,” reported Katy Bray, Ph.D., instructed Clinical News These days. Dr. Bray is a public engagement manager at Alzheimer’s Study Uk and was not concerned in the research.

“It is tricky to know how these situations might lead to the improvement of the ailment or if they could also be pretty early symptoms,” Dr. Bray advised Healthcare News Today.

The study appears in The Lancet Electronic Overall health.

The scientists analyzed the key health care documents of 20,214 people today with Alzheimer’s disease in the United Kingdom and 19,458 folks with Alzheimer’s in France.

They compared every single person’s health-related records with a command matched for intercourse and age who had not been given a diagnosis of a progressive brain sickness through the 15-yr analyze period.

Out of the 123 health and fitness conditions they investigated, 10 had a statistically substantial affiliation with a analysis of Alzheimer’s disorder 2–10 years afterwards in France and the U.K.

Some of the ailments, this kind of as despair, hearing decline, and sleep issues, are by now recognised threat things for Alzheimer’s.

Even so, this examine was the initially to identify constipation as a doable possibility element. The hyperlink involving the two problems became obvious 7 several years ahead of the prognosis of Alzheimer’s.

Apparently, constipation is also affiliated with melancholy and is an founded early sign of other mind health conditions, such as Lewy-system dementia and Parkinson’s sickness.

“The connections manufactured permitted us to ensure regarded associations, this sort of as listening to challenges or despair, and other fewer-acknowledged factors or early indications, such as cervical spondylosis or constipation,” says Thomas Nedelec, Ph.D., the initially creator of the examine.

“The query stays as to no matter if the health and fitness issues encountered are possibility components, symptoms, or warning signals of the sickness,” he additional.

In their paper, the authors conclude:

“Our results make it attainable to product the feasible trajectories of possibility elements in the period of time previous the prognosis of Alzheimer’s sickness, supplying new insights into attainable home windows for prevention.”

The study had some notable limitations. For example, it was not able to just take other chance factors that lead to Alzheimer’s, together with schooling level, ethnicity, socioeconomic position, and genetics, into account.

“This study provides a prosperity of data to our knowing of mental problems, these kinds of as despair, as a possibility component for dementia,” stated Claire Sexton, Ph.D., director of scientific programs and outreach at the Alzheimer’s Affiliation in the United States, who was not associated in the examine.

Even so, she emphasized that for the reason that their review was observational, somewhat than a medical trial, for instance, the scientists were unable to create no matter whether despair helps cause Alzheimer’s.

“Just mainly because a person has despair does not indicate they will go on to produce Alzheimer’s,” Dr. Sexton instructed MNT.

“However, these details guidance the strategy that using treatment of one’s psychological wellbeing is exceptionally crucial for total effectively-currently being and perhaps cognitive overall health,” she extra.

One more recent research also located an association amongst mental well being conditions and dementia.

In 2020, the Lancet Fee on dementia additional 3 new modifiable danger factors: too much alcohol use, head injury, and air pollution to its present listing, which contains:

  • hypertension
  • cigarette smoking
  • weight problems
  • depression
  • actual physical inactivity
  • diabetic issues

The report concluded that modifying all the risk components that scientists have determined could reduce or delay dementia in up to 40{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of persons.

“While midlife is rising as a key time for dementia chance, it’s never ever way too early or as well late in life to get motion on mind health,” Dr. Bray told MNT.

“This contains not smoking, only ingesting in moderation, remaining mentally and bodily energetic, consuming a well balanced eating plan, and keeping cholesterol and blood tension stages in verify,” she said.

Study finds 4 risk factors

A healthcare worker places tubes of bloods on a test tube rack to be tested.Share on Pinterest
A healthcare worker places blood tubes into test racks at the Valdebernardo Transfusion Center, on June 14, 2021, in Madrid, Spain. Alberto Ortega/Europa Press via Getty Images
  • Researchers have been trying to understand long COVID to determine which patients are at higher risk and to find treatments.
  • A new study has found four factors associated with future long COVID symptoms, including the Epstein-Barr virus (EBV) — a type of herpes virus — which is reactivated early on in the disease.
  • Among the other factors are certain autoantibodies, which are also present in autoimmune conditions and in people who have type 2 diabetes.
  • These findings could help scientists find ways to prevent long COVID or further explore treatments such as antiviral therapy.

Long COVID has largely remained a mystery for scientists. Initially only thought to affect very severe cases of COVID-19, patients with mild cases proved otherwise.

Long COVID, also known as post-acute sequelae SARS-CoV-2 infection (PASC) in medicine, can be characterized as an amalgamation of lingering symptoms long after the acute infection has cleared. These symptoms are often respiratory or physical, but there are increasing reports of gastrointestinal and neurological symptoms.

This wide systemic response and ambiguities surrounding the condition have prompted researchers to pinpoint those at higher risk and develop effective treatments for the long-term condition.

In a recent study, researchers from several universities and centers, including the University of Washington, the Institute for Systems Biology (ISB), and Swedish Medical Center in Seattle, discovered that four biological factors might help predict whether a patient goes on to develop long COVID.

The study, which appears in the journal Cell, saw that certain markers that appear early in a COVID-19 infection signaled an increased risk of developing long COVID symptoms weeks later.

“We’ve been carrying out large studies of COVID-19 patients since the start of the pandemic, and so extending those studies to long COVID was a natural extension of that work since many of our patients were experiencing long COVID,” said ISB president Prof. Jim Heath, Ph.D., co-corresponding author of the study.

As part of the study, the researchers followed 309 patients aged 18–89 for 2–3 months after being diagnosed with COVID-19.

Of these patients, 71{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} were hospitalized, while the remaining were outpatients. The patients were questioned about 20 long covid symptoms.

These were grouped as:

  • respiratory viral symptoms — cough, fatigue, shortness of breath, fever or chills, muscle/body aches, nausea
  • gastrointestinal — diarrhea, abdominal pain
  • neurologic — anxiety, blurred vision, depression, memory problems, difficulty concentrating, difficulty sleeping, dizziness, headache
  • anosmia/dysgeusia — loss of taste, loss of smell

Out of these patients, 37{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} reported experiencing at least three or more symptoms of long COVID, and 24{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} said they experienced one or two symptoms.

Researchers then analyzed their blood samples and nasal swabs and found four factors associated with a higher chance of getting long COVID.

These factors were:

  1. The level of coronavirus RNA in the patient’s blood.
  2. The presence of certain autoantibodies.
  3. The reactivation of the EBV.
  4. Having type 2 diabetes.

Of the patients who had three or more symptoms, 95{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} had at least one of these four factors.

Female patients or patients with chronic obstructive pulmonary disease (COPD) were more likely to present with at least three long COVID symptoms.

How these indicators may signal long COVID

The patients who had a high level of SARS-CoV-2 RNA in their blood early in the infection, which means they had a higher viral load, were more likely to develop long COVID symptoms.

A higher viral load has been linked to more severe COVID-19 and an increased risk of death. The more severe the disease, the more time it takes the body to clear the virus.

The patients who had autoantibodies, or the type of antibodies associated with conditions such as rheumatoid arthritis and lupus where the body mistakenly attacks its own tissues, were also more likely to be diagnosed with long COVID.

The same patients also had low amounts of protective antibodies that neutralized SARS-CoV-2, which the researchers said made them more susceptible to so-called breakthrough infections.

Autoantibodies were seen as the most influential indicator in developing long COVID.

Two-thirds of the patients had autoantibodies, while the other three factors were only present in a third of the patients.

The third factor was the reactivation of the EBV, which is estimated to infect 95{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of the healthy population during the early years of life but often lays dormant. The virus can cause infectious mononucleosis and other illnesses.

The researchers said this reactivation was likely triggered by immune dysregulation during COVID-19 infection.

The final factor the study found associated with a higher risk of long COVID was having type 2 diabetes, one of the many chronic health conditions scientists suspect could heighten this risk.

Weighing on the importance of this study, Dr. Donald J. Alcendor, Ph.D., associate professor in microbiology, immunology, and physiology at Meharry Medical College, and associate professor adjunct of infectious diseases at Vanderbilt University Medical Center, said:

“This is the beginning of truly understanding the complexities of long COVID. There is a rationale with some these blood markers, and to take this study to scale would only amplify its significance to the body of knowledge being developed to better understand post-COVID syndrome.”

Dr. Kyle Freese, Ph.D., chief epidemiologist and chief scientific officer at STChealth, said it made sense that a high viral load early in diagnosis was associated with certain PASC outcomes, in particular, memory problems, fatigue, difficulty concentrating, and sputum.

“There is certainly a biologically plausible link between certain biomarkers and/or viral load and the health outcomes associated with long COVID, particularly those associated with organ system dysfunction,” he said.

Dr. Alan Bulbin, director of infectious diseases at Catholic Health’s St. Francis Hospital and Heart Center in Roslyn, New York, who was also not involved in the study, commented:

“The high serum viral load is not surprising. But the finding of EBV by PCR was surprising, with the idea of immune dysregulation as the link.”

Dr. Alcendor pointed out that latent EBV reactivation did not usually occur in immunocompetent individuals, i.e., people with normal functioning immune systems.

“It would be interesting to know if there is a reaction of other latent viruses in patients with post-COVID syndrome,” he said.

He added that he was surprised that cytomegalovirus (CMV), another virus related to the herpes virus that causes cold sores and chickenpox, was not detected in the bloods of long COVID patients.

Dr. Bulbin said more confirmation was needed to establish whether EBV was a cause of long COVID or just an associated marker.

Meanwhile, Dr. Heath said the relatively small number of PASC factors they found that could anticipate long COVID was surprising. Another interesting finding was that the PASC factors are also associated with different symptoms of long COVID, including neurological or gastrointestinal symptoms.

“The relative importance of those PASC factors, and the fact that they don’t necessarily associate with COVID-19 severity, also surprised us,” he said.

Dr. Heath said that the link between PASC and systemic lupus erythematosus (SLE), the most common form of lupus, was also unexpected.

“This relation is evident from the immunology, even in patients who had no previous reports of lupus or other autoimmune diseases,” he explained.

Dr. Freese pointed out that only 6{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} of those with detectable autoantibodies had a confirmed history of autoimmune disorder.

“It is possible that this is a sign of subclinical disease and could explain why there is an association between these markers and PASC,” he said.

The identification of these four major indicators could help scientists design interventions to help people with long-haul COVID-19. However, more research will be needed to confirm them.

Dr. Bulbin said it would be interesting to see if the same results were obtained with Omicron.

Dr. Heath noted the study suggested that administering antivirals very early in the disease course could reduce long COVID cases, as well as reduce infection severity.

“Any profile of predictable markers [is] always useful prognostically for any illness, but here suggests early intervention such as antiviral treatment might impact the outcome in a subset of patients with these markers.”

– Dr. Alan Bulbin

The researchers also hypothesized that antivirals could also help with conditions linked to EBV, such as multiple sclerosis (MS) and chronic fatigue syndrome, which produce symptoms similar to some long COVID cases.

The study also suggests that other treatments may also alleviate long COVID symptoms in certain cases.

One such treatment could be cortisol replacement therapy.

The researchers found that patients with lingering respiratory problems had low levels of the stress hormone cortisol.

Dr. Alcendor said that low cortisol levels could be attributable to steroids used to treat COVID-19 but that it returns to normal after recovery.

“It is likely that a more thorough investigation of how the autoantibodies interfere with normal immune responses may also lead to treatment possibilities,” Dr. Heath added.

Dr. Heath said that although a large number of patients was studied on the whole, the number of patients with specific symptoms and specific PASC factors was relatively small.

“This means that for certain PASC, such as cardiac-related, we can’t say much. Also, we are looking at relatively early PASC, so we didn’t look at patients who were experiencing long-term PASC,” he said.

Dr. Alcendor said the study’s biggest limitations were that children and pregnant women were excluded, and it was not clear if it included a significant number of African-American or Hispanic patients, which could help address health disparities.

“[Symptoms] were self-reported by the patients. The timing of SARS-COV-2 infection is not uniform among patients,” he added.

Dr. Heath also said that research around autoantibodies could be expanded.

“We only looked at a few autoantibodies, and so, we might be missing some critical ones,” he said.

Dr. Bulbin agreed.

“I like the idea of trying to predict future problems with a profile as described in the report, but I think we would need more corroborating studies to confirm the specificity of these markers,” he said.

Dr. Freese said future research could focus on whether the severity of long COVID persists over time and whether one’s health at infection, whether mild or not, impacts the likelihood of developing long COVID.

The study has brought scientists closer to unraveling the biological mechanism behind long COVID.

It has found four key indicators that are associated with a higher risk of developing long COVID and an array of lingering symptoms.

They are viral load in the blood, the presence of certain autoantibodies, the reactivation of EBV, and having pre-existing type 2 diabetes. However, it is important to remember that this study does not show a direct cause-and-effect relationship.

“The clinical implications would suggest that patients that have COVID-19 or are recovering should be screened for these biomarkers that may be linked to the development of [long COVID],” Dr. Alcendor told Medical News Today.

Although the research remains largely exploratory and more evidence is needed to confirm the findings, the study could inspire better treatment for COVID-19 long haulers.

“These biomarkers may also provide information for the development of innovative therapeutic interventions for the treatment of post-COVID syndrome. Identifying the immune signature of patients that develop [long COVID] could lead to the development of specific therapies designed for specific patients.”

– Dr. Donald J. Alcendor, Ph.D.