CDC report on ‘superbugs,’ FDA authorizes Novavax

CDC report on ‘superbugs,’ FDA authorizes Novavax

Pfizer Covid pill: FDA authorizes first oral antiviral Paxlovid to treat coronavirus infection

This is the 1st antiviral Covid-19 tablet approved for sick persons to just take at property, ahead of they get sick sufficient to be hospitalized.

High-hazard persons age 12 and more mature who weigh at minimum 88 lbs . and have a positive SARS-CoV-2 test are suitable for this treatment and will want to have it approved by a doctor.

The pill “should really be initiated as soon as doable right after analysis of Covid-19 and within just five times of symptom onset,” in accordance to an Food and drug administration statement.

Paxlovid combines a new antiviral drug named nirmatrelvir and an older just one known as ritonavir and is administered as three tablets specified 2 times a working day for five days.

Last week, Pfizer launched updated final results that confirmed the cure slice the chance of hospitalization or dying by 89{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} if provided to high-chance adults in a couple days of their very first signs. If presented within just the initial five days of signs, the efficacy was comparable: 88{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}.

Finding a Covid-19 test is a struggle right now in the US as Omicron and holiday plans collide

“Modern authorization of PAXLOVID represents an additional incredible case in point of how science will enable us finally defeat this pandemic, which, even two a long time in, carries on to disrupt and devastate life throughout the planet. This breakthrough treatment, which has been demonstrated to considerably lessen hospitalizations and fatalities and can be taken at home, will alter the way we treat COVID-19, and hopefully support lessen some of the important pressures facing our health care and hospital techniques,” Pfizer Chairman and CEO Albert Bourla explained in a statement. “Pfizer stands ready to start out shipping and delivery in the U.S. instantly to assistance get PAXLOVID into the arms of correct sufferers as immediately as doable.”

In November, the Biden administration announced that it would order 10 million treatment method programs for $5.295 billion. President Biden stated he was inspired by the “promising info” from Pfizer and reported the drug would “mark a considerable move forward in our route out of the pandemic.”

He called Paxlovid a “potentially impressive instrument in our combat in opposition to the virus, which includes the Omicron variant,” but pressured that acquiring vaccinated and getting a booster shot remained “the most significant resources we have to conserve lives.”

The Fda emphasized in a statement that Paxlovid is not for pre- or post-exposure avoidance of Covid-19 and “is not a substitute for vaccination in men and women for whom COVID-19 vaccination and a booster dose are proposed.”

Separately, Merck has asked for crisis use authorization for its antiviral capsule, molnupiravir. It was narrowly advisable by FDA’s advisers in a 13-10 vote at the end of November following details showed it reduce the risk of hospitalization or demise by 30{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809} amid high-hazard grownups. This was lessen than an previously investigation suggesting that selection could be about 50{cfdf3f5372635aeb15fd3e2aecc7cb5d7150695e02bd72e0a44f1581164ad809}. The Food and drug administration has not introduced irrespective of whether it will authorize the treatment.

Remdesivir, offered beneath the manufacturer name Veklury, is the only antiviral accredited by Fda for treatment of Covid-19. It really is specified intravenously, not as a pill that can be taken at house.

FDA authorizes Pfizer booster for kids ages 16-17: Live updates

F.D.A. Authorizes Coronavirus Booster Shots for All Adults

WASHINGTON — The Food and Drug Administration on Friday authorized booster shots of the two the Pfizer-BioNTech and Moderna vaccines for absolutely everyone 18 and more mature, opening up eligibility to tens of hundreds of thousands extra fully vaccinated grownups.

The transfer simplifies eligibility, fulfills a pledge by President Biden to supply the pictures to just about every American grownup and formally lets a observe already in put in at minimum 10 states. Fearful that waning defense and the onset of wintertime will established off a wave of breakthrough bacterial infections, a rising quantity of governors experienced currently provided boosters to every person 18 and more mature forward of the holiday seasons.

The company claimed the expansion was justified by presently out there scientific trial details as well as genuine-environment proof. In a statement, Dr. Peter Marks, who sales opportunities the F.D.A. division that regulates vaccines, extra: “Streamlining the eligibility requirements and creating booster doses offered to all people 18 several years of age and older will also aid to get rid of confusion about who could receive a booster dose and be certain booster doses are readily available to all who might require just one.”

Dr. Anthony S. Fauci, the federal government’s prime infectious disorder expert, has argued relentlessly more than the past month for booster shots for all older people, a place shared by most of Mr. Biden’s other health advisers. General public well being authorities who argue that healthy youthful older people do not need to have them, he has said, are ignoring the hazards of symptomatic Covid-19.

“Enough is plenty of. Let’s get shifting on below,” he stated at an occasion Wednesday night time. “We know what the info are.”

If the Centers for Disease Manage and Avoidance agrees, all grownups who gained a 2nd shot of either Pfizer or Moderna at the very least 6 months back will most probably be able to get a booster shot by the weekend. The agency’s outside advisers are conference to talk about the situation at midday Friday and will hear from Pfizer, Moderna and C.D.C. workers. A vote is scheduled for 2:45 p.m.

At a White Residence briefing on Wednesday, Dr. Rochelle Walensky, the C.D.C. director, promised that the agency would “quickly review the safety and usefulness knowledge and make suggestions as shortly as we hear from F.D.A.”

The F.D.A.’s motion came soon after months of fierce debate within the administration and the scientific community about who wanted booster photographs, and when. As huge experiments showed defense from all three federally approved vaccines keeping strongly, some outside the house advisers to the F.D.A. and C.D.C. consistently expressed distress with how promptly the administration was relocating to supply the shots.

When the F.D.A. has been evaluating booster details for months, it granted the companies’ requests with exceptional speed. Pfizer-BioNTech filed its request around 10 days back, and Moderna introduced Wednesday that it experienced applied but did not say when.

The agency said that it did not convene its impartial vaccine advisory committee for the reason that the panel experienced already experienced discussed the use of booster pictures thoroughly and “the requests do not increase concerns that would profit from further discussion.” The panel’s tips are nonbinding.

For Moderna, regulators stated, the facts confirmed that 149 scientific trial contributors who received a booster dose experienced higher antibody degrees in comparison with 1,055 review volunteers who acquired only two doses. They claimed Pfizer’s info for 200 members in a clinical trial showed the booster shot raised antibody stages compared to 1 thirty day period soon after a next shot.

Critics have mentioned the administration’s booster marketing campaign was determined by functional or political causes more than scientific kinds. Some explained that federal regulators had been examining safety and efficacy information on the fly. Others have fearful that moving to obvious Pfizer and Moderna booster doses for all older people may possibly inadvertently undermine the vaccines and counsel that two doses are not strongly protecting.

“The proof isn’t there that a large rollout of boosters is definitely going to have that considerably impact on the epidemic,” said Ira M. Longini Jr., a vaccine professional and professor of biostatistics at the College of Florida. He explained that booster doses could boost security at least briefly and may aid a jittery community sense as if they have a further tool in the pandemic, but would do tiny to halt transmission of the virus, which is becoming pushed by the unvaccinated.

Other general public overall health specialists have argued that data from Israel, which rolled out an aggressive booster campaign over the summer time, suggests boosters can reduce transmission premiums they say the added shots are necessary equally to counteract waning security and to limit confusion.

Elaborate eligibility rules coupled with the government’s recent determination to permit men and women pick among the all three vaccines for their booster have also still left the general public somewhat befuddled, proponents of the F.D.A.’s decision on Friday say.

“This conclusion by F.D.A. is overdue,” said Dr. Elizabeth McNally, director of the Centre for Genetic Drugs at Northwestern University’s Feinberg College of Drugs.

“Many individuals experienced difficulties comprehending regardless of whether they ought to or should not get boosters,” she explained in a statement. “This information is considerably clearer — get a booster!”

There is close to universal arrangement among federal officials, point out overall health leaders and exterior experts that persuading the tens of hundreds of thousands of Us citizens who have but to get even their initially shot should stay the prime precedence in making an attempt to curb the pandemic.

Extra than 182 million grown ups in the United States, or 71 percent, are totally vaccinated. So significantly, extra than 32 million of them have gotten an further shot.

Until eventually now, all those qualified for boosters involved folks 65 and older, people of extensive-term treatment facilities, folks with fundamental health care conditions, and individuals whose work or institutional living conditions heightened their risk.

All recipients of Johnson & Johnson’s a single-shot vaccine have presently been cleared to get a booster shot at least two months just after their injection.

Jason L. Schwartz, an affiliate professor of health coverage at the Yale University of Public Wellbeing, explained the most up-to-date shift was “a recognition that the present-day approach to booster tips just is not performing.”

“It’s so confusing that I feel the public has type of shrugged at the importance of boosters,” he explained. “And the teams for whom it’s really important to get boosters — the older people today, the lengthy-time period care people, folks with health-related conditions — aren’t finding boosters at the rates they must. It’s time for a reset.”

The booster rollout is increasing even as community wellbeing industry experts carry on to argue about no matter if young, balanced grownups need added defense. The argument is more robust for recipients of Pfizer’s vaccine than for recipients of Moderna’s, whose security has proved much more strong.

When some reports have observed that the Pfizer vaccine’s effectiveness in opposition to infection and hospitalization drops about 4 months following the 2nd dose, Moderna’s usefulness has remained steadier.

At the similar time, regulators have been anxious by information from Nordic nations and elsewhere suggesting that youthful male Moderna recipients may possibly confront heightened pitfalls of myocarditis, or inflammation of the heart muscle mass — a facet impact that has also been tied to the Pfizer vaccine. The F.D.A. on Friday current the vaccine’s simple fact sheets to take note that some experiments have advised there may possibly be an amplified hazard in adult males beneath 40 “relative to other authorized or authorized mRNA Covid-19 vaccines.”

Regulators stated that while facts was constrained, evidenced proposed a reduced hazard of myocarditis following booster doses than right after 2nd doses of the shot. Concerns about myocarditis are behind the F.D.A.’s selection to wait around to authorize the Moderna vaccine for adolescents.

Scientists have explained the absolute possibility nevertheless continues to be incredibly small, most scenarios are gentle and solve immediately and that Covid-19 can also bring about myocarditis.

The F.D.A. mentioned on Friday that in reviewing broader booster eligibility for Moderna’s and Pfizer’s vaccines, it had examined the latest virus instances and actual-earth knowledge on the dangers of myocarditis and concluded that the added benefits of a booster shot outweighed the challenges. The F.D.A. also noted that the two organizations had been conducting more scientific studies on myocarditis possibility.

At the coronary heart of the booster debate is the query of what vaccines are meant to do. Critics of the administration’s policy argue that despite some diploma of waning safety, the vaccines are even now fulfilling their mission of guarding versus severe illness and hospitalization.

Booster advocates like Dr. Fauci counter that the vaccines ought to also protect against symptomatic condition, in particular considering that some clients prevent hospitalization but endure extensive-time period repercussions.

“I really do not know of any other vaccine that we only stress about trying to keep persons out of the hospitals,” Dr. Fauci claimed at a White House briefing Wednesday. “I believe an significant issue is to avoid people today from finding symptomatic illness,” which includes younger men and women.

In current weeks, point out following point out has moved to allow for booster shots for all older people, which include Massachusetts, Rhode Island, Kansas, Kentucky, Maine, Vermont, Arkansas, California, Colorado and New Mexico.

A host of other nations around the world have taken the exact same technique, which includes Australia, Brazil, Canada, Germany, Hungary, Israel, Japan, Norway and Saudi Arabia. Regulators for the European Union have authorized booster doses of equally Moderna and Pfizer-BioNTech for all adults.

Kitty Bennett contributed research.

Today’s coronavirus news: Health Canada authorizes the use of the Pfizer vaccine as a booster shot; Ontario reporting 441 new COVID-19 cases

The latest coronavirus news from Canada and around the world Tuesday. This file will be updated throughout the day. Web links to longer stories if available.

4:10 p.m.: Ontario will “stay the course” with its less restrictive COVID-19 measures despite a 41 per cent increase in infections over the last 10 days, and leave local health units to deal with flare-ups for now, says Health Minister Christine Elliott.

“We know that the numbers have gone up somewhat. We anticipated that would happen,” Elliott told reporters Tuesday as the seven-day average of new cases rose for the tenth day in a row and the province reported 441 more people testing positive for the virus.

“So what we’re seeing right now are largely regional outbreaks which we’re going to be dealing with regionally.”

Read the full story here: Ontario will ‘stay the course’ with current COVID-19 restrictions despite surge in new cases, Christine Elliott says

3:45 p.m.: Health officials in Nova Scotia are reporting one new COVID-19-related death as an outbreak of the disease in a long-term care home continues to grow in another part of the province.

The Health Department says a man in his 80s in the province’s eastern zone has died and 56 new cases of the disease have been identified since Monday.

Officials have also noted community spread of the disease in the northern and western regions of the province, largely related to transmission of the virus during a multi-day faith gathering.

The gathering has been directly connected to the ongoing outbreak at East Cumberland Lodge, a long-term care home in Pugwash, as well as transmission at other faith services and in workplaces.

Thirteen more residents at the home and a second staff member have tested positive for the disease, bringing the total case count at the residence to 19.

The province now has 281 active cases of COVID-19, with 10 people in hospital and two in ICU.

3:30 p.m.: Quebec is expanding eligibility for COVID-19 vaccine booster doses to the general population aged 70 and older, Health Minister Christian Dubé said Tuesday.

Third doses of mRNA vaccines will also be available by the end of the month to residents who received two doses of the Oxford-AstraZeneca vaccine, Dubé added. Those residents will need to wait six months from their second doses for a third shot.

“I want to reassure the population, it’s not because we are worried about AstraZeneca, it’s because we want to make sure there’s an extra protection — especially after six months,” Dubé told reporters.

The government made the decision following recommendations by Quebec’s immunization committee. Despite Health Canada announcing on Tuesday it authorized boosters for all adults, Quebec said it would stick to its plan. Public health director Dr. Horacio Arruda told reporters the government preferred to follow the recommendations of its vaccine committee.

“Even if there is a recommendation from Canada, we refer almost all the time to our own committee because they are aware of our own epidemiology,” Arruda said.

Starting Nov. 16, people aged 80 and older will be able to book an appointment for a third dose, followed by people 75 and up two days later and then residents 70 and older on Nov. 23. Residents of any age who received the AstraZeneca vaccine can start booking third doses on Nov. 25. All groups must wait six months since their second doses to book a third shot.

In late September, the province announced it would offer people in long-term care homes and seniors residences booster shots to prevent outbreaks among vulnerable residents. Since August, Quebec has offered a third dose of COVID-19 vaccine to people who are severely immunocompromised.

For the general population, protection from two doses after six months remains high — especially against severe infection and death, according to Dr. André Veillette, an immunologist at the Montreal Clinical Research Institute. Veillette, however, said protection will inevitably start to decline.

“Some people will say it’s not a problem, because of what we call memory cells,” Veillette said in an interview on Monday. “That’s when your antibodies are low, then the memory cells are activated if you get infected, and then a week later, they will make a lot of antibodies.”

The problem, he said, is that for some people — and maybe eventually for everybody — a week of infection is too long to wait for the antibodies to kick in.

Veillette said the government’s immediate priority should be identifying high-risk groups and giving them third doses. He also said he believes boosters will eventually be available for all Quebecers, even for young people.

“We have billions of doses in Ottawa waiting on shelves, and tens of millions more have been bought for next year by the government,” Veillette said. “The vaccines are available.”

Arruda, however, said there is no need yet to offer a third dose to people under 70 years old.

“For the others that are healthy, and under 70, there are no recommendations for a third dose,” Arruda said. “Two doses are still a good thing.”

Meanwhile, Quebec reported 545 new cases of COVID-19 on Tuesday and six more deaths attributed to the novel coronavirus. Health officials said COVID-19-related hospitalizations dropped by six, to 219, and there were 45 people in intensive care, a drop of three.

The Health Department said 9,406 vaccine doses were administered in the previous 24 hours. Quebec’s public health institute said about 90.8 per cent of residents aged 12 and older have received at least one dose of COVID-19 vaccine and 88.2 per cent are considered adequately vaccinated.

Quebec has 5,219 active reported cases of COVID-19.

2 p.m. Packers quarterback Aaron Rodgers remains upset with the public’s reception to his admission that he is not vaccinated against COVID-19, according to People.

Rodgers tested positive for COVID-19 last week before missing Green Bay’s loss to the Chiefs on Sunday. Rodgers previously indicated he was vaccinated in an August press conference, telling the media when asked about his status, “I’m immunized.”

Green Bay’s signal-caller made an appearance on The Pat McAfee Show on Friday to address the apparent obfuscation, a segment that featured misinformation on both COVID-19 and vaccines. Rodgers now feels as though he’s “being crucified” for his remarks, per People.

1:34 p.m. Canadians are scrambling to get mortgage pre-approvals and rate holds as economists predict the pandemic-long stretch of low interest rates will soon end.

Estée Zacks says she recently noticed a surge in requests for rate holds, which freeze mortgage rates for up to 130 days.

The owner of Strategic Mortgage Solutions Inc. says her clients see the holds as a way to get a leg up on hot markets like Toronto that are favouring sellers.

CIBC Capital Markets analyst Benjamin Tal says even a one per cent increase in mortgage rates from current levels will cost an average new buyer $230 or 12 per cent more in additional monthly interest payments.

BMO Capital Markets senior economist Robert Kavcic says five-year fixed mortgage rates are already creeping higher, but people with pre-approvals in hand probably have another month or two to buy a home.

1:20 p.m. Quebec needs to quickly provide a coherent plan on how it intends to offer third doses of COVID-19 vaccine to the general population, Dr. André Veillette, an immunologist at the Montreal Clinical Research Institute, said Monday.

The province announced in late September it would offer people in long-term care homes and seniors residences booster shots to prevent outbreaks among vulnerable residents. Since August, Quebec has offered a third dose of COVID-19 vaccine to people who are severely immunocompromised.

While boosters for the general population weren’t part of the National Advisory Committee on Immunization’s recommendations at the end of October, provinces such as Ontario and British Columbia have already announced plans to expand eligibility for third shots.

1 p.m. Ontario plans to spend $12.4 million on more mental health and addictions supports for front-line health-care workers.

The province says $5.9 million will go to services offered through hospitals such as self-referral and intake services, online discussion groups and confidential clinician support.

There is also $1.9 million allocated for psychologist services specializing in trauma, anxiety and other conditions and $4.6 million for workplace mental health training.

12:45 p.m. Ontario’s health minister says the government isn’t changing course on its reopening plan despite a recent rise in COVID-19 infections.

Health Minister Christine Elliott says a bump in cases was anticipated during the colder weather as people move indoors, and that was factored into the province’s plans.

Experts told The Canadian Press this week that cold weather and the lifting of provincial crowd restrictions on some venues like stadiums and restaurants might be behind the growth in cases.

Tuesday saw 441 new cases reported in the province and seven-day average of 492 daily infections, up from 371 a week ago.

11:35 a.m. (updated) Health Canada has approved a booster of Pfizer-BioNTech’s COVID-19 vaccine for people over the age of 18.

The booster is designed to help people with their first two COVID-19 vaccine doses maintain their protection against the virus over time.

The booster is identical to the regular Pfizer-BioNTech vaccine, and is to be administered at least six months after the first two vaccine doses.

Different provinces have employed different rollout strategies for booster doses, and mRNA vaccines like Pfizer-BioNTech have already been used to offer longer-lasting protection to high-risk people in several parts of the country.

The National Advisory Committee on Immunization says there is no evidence of waning protection against over time against severe COVID-19 in the general vaccinated population.

11:22 a.m. Conservative MP Marilyn Gladu is apologizing for sharing misinformation about the severity of COVID-19 and the safety and efficacy of vaccines.

In a statement Tuesday, Gladu called her remarks “inappropriate.”

“Upon reflection, I recognize how dangerous it is to share misinformation about the severity of COVID-19 and the safety and efficacy of vaccines,” she said.

“I retract these comments in full.”

Read the full story from the Star’s Stephanie Levitz

11 a.m. India’s coronavirus crisis, which was killing thousands of people a day just seven months ago, has eased after the nation’s leaders revamped their policies and dramatically ramped up their vaccination drive.

Now, as India celebrates the delivery of its 1 billionth dose, a feat that until recently seemed improbable, public health experts are sounding a new warning: The turnaround is losing steam.

Vaccinations are slowing down. As the temperature dips amid India’s most important festival season, people are crowding markets and hosting unmasked friends and family indoors. And the government is telling vaccination campaign volunteers like Namanjaya Khobragade that they are no longer needed.

“Now is not the time to let our guard down,” said Khobragade, a coordinator for a health nonprofit in the eastern state of Jharkhand. “Many people have taken just the first vaccine. We cannot leave them like this. We need to increase the intensity.”

10:15 a.m. (updated) Ontario is reporting another 441 COVID-19 cases and three more deaths, according to its latest report released Tuesday morning.

Ontario has administered 13,049 vaccine doses since its last daily update, with 22,637,009 vaccines given in total as of 8 p.m. the previous night.

According to the Star’s vaccine tracker, 11,539,002 people in Ontario have received at least one shot. That works out to approximately 88.5 per cent of the eligible population 12 years and older, and the equivalent of 77.6 per cent of the total population, including those not yet eligible for the vaccine.

Read the full story from the Star’s Urbi Khan

10 a.m. A giant gap exists in Waterloo Region’s defences against COVID-19. About 126,000 residents are not yet vaccinated, giving the virus plenty of opportunity to spread through the community.

“This is equivalent to an entire mid-sized city such as Cambridge or Waterloo not being immunized,” medical officer of health Dr. Hsiu-Li Wang told regional council at Tuesday’s meeting.

Almost 44,000 people over 12 are not immunized. Almost 82,000 children under 12 are not yet eligible to get the vaccine.

9:45 a.m. The vast majority of staff members at Waterloo Region’s and Guelph-Wellington’s long-term- care homes are vaccinated, with the average staff vaccination rate in the neighbouring public health units sitting at 89.8 per cent, according to Ministry of Ontario data, last updated on Oct. 1.

The Ontario Ministry of Long-Term Care updates data on a monthly basis, typically in the middle of the month.

But with the provincial government issuing a vaccine mandate that takes place Nov. 15 and third-dose booster shots now available for all long-term care workers, almost all long-term care homes in the region will need to work on getting their staff 100 per cent vaccinated.

9:30 a.m. The health board governing Quebec’s Nunavik region says the COVID-19 situation in the northern territory is worse than it’s ever been.

Health officials reported 30 new cases Monday across the region, which is home to 14 Inuit communities.

The territory has 259 active reported cases.

Quebec’s public health institute says Nunavik is the most affected part of the province, with about 1,450 active COVID-19 cases per 100,000 people.

9:13 a.m. Book sales have thrived during the pandemic after initial concerns that it might hurt the publishing business. Come the holidays, some new nonfiction might hit your gifting sweet spots.

9 a.m. Hospitals in the southern Dutch province of Limburg warned the government Tuesday that they can no longer cope with new COVID-19 patients amid soaring rates of coronavirus infections.

Five hospitals in the province that borders both Belgium and Germany raised the alarm in a statement that said: “We are heading straight for a healthcare blockage and the entire system is grinding to a standstill.”

They added that, “we are convinced that other parts of the Netherlands will soon follow.”

Amid an autumn surge across much of Europe, the seven-day rolling average of daily new cases in the Netherlands has almost doubled over the past two weeks from 30.88 to 61.12 new cases per 100,000 people despite more than 80 per cent of the adult population being fully vaccinated.

8:45 a.m. The morgue in Romania’s main hospital has no space for the dead any more. In a stark illustration of the human cost of the coronavirus surge sweeping the nation, bodies of COVID-19 victims, wrapped in black plastic bags, line a hallway of the hospital in the capital, Bucharest.

Hundreds of people have been dying each day for the past two months in Romania which has been among the hardest-hit in the current virus onslaught raging through Central and Eastern European nations, where far fewer people have been vaccinated than in Western Europe.

A country of 19 million people, Romania currently has among the highest death rates in Europe. Last month the World Health Organization sent a team to help with the nation’s pandemic response.

8:30 a.m. A player on Germany’s national soccer team has tested positive for the coronavirus and four more are in quarantine as a precaution ahead of World Cup qualifying games against Liechtenstein and Armenia.

The German soccer federation said Tuesday that the unnamed player was fully vaccinated and does not have any symptoms. The other four tested negative for the virus but have been instructed by the local health authority in Wolfsburg to isolate because of their proximity to the infected player.

Germany has already qualified for next year’s World Cup ahead of its final qualifiers. The team hosts Liechtenstein in Wolfsburg on Thursday and then plays Armenia in Yerevan on Sunday.

8 a.m. Peel Public Health has confirmed seven schools in the region have active COVID-19 outbreaks. From Sept. 1 to Nov. 2, there have been a total of 31 outbreaks at schools in Peel region.

An outbreak is declared if the facility has two or more COVID-19 cases with an epidemiological link, which means at least one of the patients could have acquired the infection in the school.

7:46 a.m. Peel’s health agency is advising residents who attended a recent wedding event in Mississauga to get tested for COVID-19.

In a media release, Peel Public Health said those who attended an Oct. 29 wedding event at the Apollo Convention Centre in Mississauga were exposed to COVID-19 and should “seek immediate testing” whether they’ve been vaccinated or not.

Those who attended the event and are not fully vaccinated should isolate while waiting for test results, the release said

7:21 a.m. Wage growth, higher costs, supply chain issues, inflation — all of these issues are driving expectations of lower corporate earnings at the end of 2021 for everyone. Dennis Mitchell, CEO and chief investment officer at Starlight Capital, isn’t surprised by that. Nor does he believe the COVID-19 pandemic fundamentally changed major trends in business like the rise of e-commerce or the oversupply of physical retail space.

Shying away from shiny investments in favour of long-term stakes in great businesses, regardless of where they happen to be, is part of Starlight Capital’s strategy. In an interview with the Star, Mitchell unpacks his firm’s philosophy on great businesses, creating a diverse team, and where he sees the office real estate market going.

6:32 a.m.: Nobody wants to say here we go again, but here we are. Ontario has lived a relatively charmed pandemic life since the summer, and it appears to be over. The province’s seven-day case average has risen approximately 30 per cent in a week; vaccination efforts are stalling as we go. One rule of the virus is that unchecked, it will spread exponentially. We’re back there.

“Do you remember where we were immediately before Thanksgiving? That’s the behaviour and the extent of restrictions that is compatible with control of the pandemic,” says Dr. Peter Juni, the scientific director of Ontario’s independent volunteer science table. “So think how it was before Thanksgiving, and think about how much you were inside with other people. You shouldn’t do it more than you did then.”

If it sounds like going backwards, it is, in the province where the premier keeps saying he never wants to go back. A return to pre-Thanksgiving restrictions would mean a return of capacity limits in restaurants, bars, gyms, theatres and at sporting events, for a start. A return to pre-Thanksgiving social patterns should be achievable, if we just keep a bigger picture in mind. This can be done.

Read the full column from the Star’s Bruce Arthur.

6:20 a.m.: The pandemic’s effects on mortality have been uneven. Life expectancy dipped in most places last year, shaving 28.1 million years off the cumulative longevity in 31 countries. But residents of a handful of places that successfully kept COVID-19 at bay — including New Zealand and Taiwan — actually lived longer.

Life expectancy is an indication of how long on average people will live once their age is taken into account, provided that there aren’t any big shifts in the number of people dying in each age bracket over time. Another measure — excess years of life lost — quantifies the impact when those changes do occur, and gives greater weight to deaths that occur at younger ages.

A study of 37 countries and territories in the journal BMJ found the pandemic was a killing field in most places. More than 28 million years of life were lost in 2020 across 31 of them, with Russia, Bulgaria, Lithuania, the U.S., and Poland recording the heaviest toll, the study led by Nazrul Islam, a physician-epidemiologist and medical statistician at the University of Oxford, found.

Years of life lost in 2020 were higher than expected everywhere except Taiwan, New Zealand, Norway, Iceland, Denmark, and South Korea.

The number of years of life lost due to Covid-19 was more than five times greater than those lost from influenza in 2015, during the worst seasonal flu epidemic since the turn of the century.

6:20 a.m.: People who are fully vaccinated are 16 times less likely to end up in intensive care wards or to die from COVID-19, an Australian study found, adding to a growing body of evidence that may bolster the case for countries to treat the disease as endemic.

6:20 a.m.: The three parties in talks to form the next German government agreed on a package of measures to tackle the latest surge in cases, seeking to avoid sweeping restrictions like school closures and curfews.

6:20 a.m.: Hong Kong needs at least six months before reopening to the world, a government adviser said. The territory must finish negotiating open borders with the mainland and boost the vaccination rate, with Hong Kong and China the only places still pursuing a “Covid Zero” strategy.

6:17 a.m.: Denmark wants to again consider COVID-19 as “a socially critical disease,” paving the way for the reintroduction of a digital pass months after the label was removed and restrictions were phased out.

The move, which still needs approval in parliament, will also allow Denmark to reintroduce other restrictions if deemed necessary. A majority seems to be backing the suggestion of the minority Social Democratic government.

The pass was introduced on July 1 but removed on Sept. 10, when Denmark declared that the outbreak no longer was to be considered “a socially critical disease,” citing the high rate of vaccination.

However, Denmark has like many other countries seen an uptick in cases, with health authorities saying the number of infections and hospitalizations has risen faster than expected.

On Monday, Health Minister Magnus Heunicke said the COVID pass must apply to nightclubs, cafes, party buses and indoor restaurants but also outdoor events where the number of people exceeds 2,000.

The Danish pass app shows a QR code with a green banner if the holder is fully vaccinated or received a first dose at least two weeks ago, has recently recovered from COVID-19 or has had a negative test in the past 72 hours. A paper version is also available.

The call to reintroduce the pass was immediately welcomed by the industry.

6:15 a.m.: Residents of a New York border town say they’re eager to welcome Canadians now that the United States has eased land border restrictions, but they worry that costly COVID-19 testing rules will keep many travellers away.

On Monday, Christmas music floated down the halls of the Champlain Centre mall in Plattsburgh, N.Y., about an hour south of Montreal, where some retailers dreamt of the return of tourist dollars — perhaps in time for the holidays.

“We cannot wait to have Canadian shoppers come back,” Emily Moosmann, the mall’s marketing director, said in an interview. “We miss hearing French in the hallway; we miss seeing their faces.”

To lure shoppers back, the mall created a web page — headed by a large maple leaf — highlighting new stores that have opened, local COVID-19 test sites and special discounts for Canadian residents.

“About 30 per cent of our traffic is Canadian, so, not seeing them here, we definitely feel the impact,” she said. While there were only a few cars with Quebec licence plates in the parking lot on Monday, Moosmann said retailers were optimistic things would pick up on the weekend.

Read the full story from the Canadian Press.

6:15 a.m.: The Yukon government has declared a state of emergency and announced a series of public health rules aimed at curbing the spread of COVID-19, including a proof-of-vaccination requirement that’s set to take effect this Saturday.

The territory says it is “moving rapidly” to implement a proof-of-vaccination system for a range of settings, including restaurants, ticketed events, fitness facilities and personal services businesses, as well as faith-based and cultural gatherings.

It says the new measures also include mandatory masks in all indoor public settings and outdoor public settings where physical distancing isn’t possible, as well as capacity limits on different types of indoor and outdoor gatherings.

While the rules will be enforced starting Nov. 13, the territory says in a statement that Yukoners are “strongly encouraged” to adopt the measures immediately.